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Abstract Senescent cells (SnCs) are increasingly recognized as key contributors to osteoarthritis, with conventional strategies centered on their elimination. However, senolytic approaches face mounting limitations, driv...

Abstract Background Mesenchymal stromal cells (MSCs) are widely used in regenerative medicine, but their clinical utility is limited by replicative senescence. Strategies that reverse aging while maintaining MSC identity...

Hematopoietic stem cells (HSCs) sustain physiological hematopoiesis by generating all hematopoietic cells. However, the connection between HSC stemness/activities and organismal lifespan, especially under stress, remains...

Background: Periodontitis combined with orthodontic treatment creates a complex inflammatory and biomechanical microenvironment in gingival tissue, where macrophages play pivotal roles in tissue remodeling and immune reg...

Abstract Osteoarthritis is an aging-related systemic disease involving the crosstalk of multiple organs/tissues in metabolism and inflammation, yet little is known about the contribution of liver and marrow adipose tissu...

The senescence of the neuro-skeletal muscle system is typified by a gradual deterioration in muscle mass, strength, neuromuscular efficacy, and cognitive capabilities, which is further exacerbated by metabolic dysregulat...

La telomerasa es la enzima responsable del mantenimiento de la longitud de los telómeros mediante la adición de secuencias repetitivas ricas en guanina, y su actividad se observa principalmente en gametos, células mad...

Telomeres are highly regulated and dynamic complexes that protect the genomic DNA and prevent the end of linear chromosomes from being misrecognized as a broken DNA. Due to the end replication problem, telomeres of somat...

ABSTRACT Background Intervertebral disc degeneration (IVDD), a prevalent spinal disorder, is closely associated with abnormal mechanical stress. The nucleus pulposus (NP), annulus fibrosus (AF), and cartilaginous endplat...

Abstract Aging is a primary risk factor for chronic diseases, with cellular senescence as an effective target to delay, prevent or alleviate age-related disorders. Here we report in vitro screening outputs from a natural...

Vascular and metabolic diseases, including atherosclerosis, aortic aneurysm and dissection, obesity, type 2 diabetes, and metabolic dysfunction–associated steatotic liver disease (MASLD), constitute a major global heal...

The clinical management of autoimmune liver diseases is frequently complicated by the concomitant presentation of hepatitic and cholestatic features, an entity clinically designated as Overlap Syndrome. While the majorit...

Materias / palabras clave: Reactive oxygen species; Radical; Oxidative stress; Antioxidant; Reactive intermediate; Senescence; Biology; Chemistry; Biochemistry; Cell biology; Catalysis

Materias / palabras clave: Biology; Proteostasis; Genome instability; Telomere; Senescence; Epigenetics; Premature aging; Bioinformatics; Telomerase; DNA damage; Genetics; Neuroscience

Durante o envelhecimento cronológico cutâneo, ocorre a modificação do material genético e a proliferação celular decresce resultando na perda de elasticidade, da capacidade de regular o metabolismo e a replicaçã...

Abstract The new edition of this well-established book is thoroughly revised and gives a comprehensive account of the role of free radicals, other reactive species (RS), and antioxidants in life, health, and disease. Cha...

At high concentrations, free radicals and radical-derived, nonradical reactive species are hazardous for living organisms and damage all major cellular constituents. At moderate concentrations, however, nitric oxide (NO)...

The physiological and molecular mechanisms of tolerance to osmotic and ionic components of salinity stress are reviewed at the cellular, organ, and whole-plant level. Plant growth responds to salinity in two phases: a ra...

Materias / palabras clave: senescence, cancer biology, rna biology, molecular biology of health and disease, molecular genetics and epigenetic regulation, tumor microenvironment and cancer immunotherapy; Science: Biology (General): Genetics

Materias / palabras clave: aging, metabolic therapies, senescence, diseases of aging, anti-aging; Medicine: Internal medicine: Special situations and conditions: Geriatrics

Materias / palabras clave: functional cytology, immunohistochemical analysis techniques; cell differentiation and death, cellular basis of diseases, biology of cell development and senescence, functional cell and tissue biology in animals and plan...

Materias / palabras clave: aging, senescence, lifespan, metabolism, genomic maintenance, dna repair; Medicine