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The fine detail provided by sequencing-based transcriptome surveys suggests that RNA-seq is likely to become the platform of choice for interrogating steady state RNA. In order to discover biologically important changes ...

A method is presented by which the gene diversity (heterozygosity) of a subdivided population can be analyzed into its components, i.e., the gene diversities within and between subpopulations. This method is applicable t...

We describe Hi-C, a method that probes the three-dimensional architecture of whole genomes by coupling proximity-based ligation with massively parallel sequencing. We constructed spatial proximity maps of the human genom...

Materias / palabras clave: Biology; Molecular genetics; Gene; Genetics; Molecular marker; Beta-glucuronidase; Library science; Gene expression; Computer science

A measure of genetic distance (D) based on the identity of genes between populations is formulated. It is defined as D = -logeI, where I is the normalized identity of genes between two populations. This genetic distance ...

A 16S rRNA gene database (http://greengenes.lbl.gov) addresses limitations of public repositories by providing chimera screening, standard alignment, and taxonomic classification using multiple published taxonomies. It w...

A mathematical model for the evolutionary change of restriction sites in mitochondrial DNA is developed. Formulas based on this model are presented for estimating the number of nucleotide substitutions between two popula...

Materias / palabras clave: Plasmid; Transformation (genetics); Escherichia coli; Plasmid preparation; Biology; Incubation; Dithiothreitol; T-DNA Binary system; DNA; Transformation efficiency; Chemistry; Genetics

The Ensembl Variant Effect Predictor is a powerful toolset for the analysis, annotation, and prioritization of genomic variants in coding and non-coding regions. It provides access to an extensive collection of genomic a...

A partir de registros de 420 estudiantes se analizaron las siguientes variables: año de ingreso (AI), año de nacimiento (AN), número de materias cursadas (nca) y número de exámenes finales de primer año aprobados (...

BACKGROUND: Correlation networks are increasingly being used in bioinformatics applications. For example, weighted gene co-expression network analysis is a systems biology method for describing the correlation patterns a...

Materias / palabras clave: plant genetics and breeding, animal genetics and breeding, genetics and breeding of microorganisms, human genetics, medical genetics, bioengineering; Science: Biology (General): Genetics

Materias / palabras clave: molecular biology, genomics, cellular biology, genetics, plant genetics; Science: Biology (General): Genetics; Science: Biology (General): Reproduction

Materias / palabras clave: genetics, genomics, genome technology, human genetics, cancer genomics, precision medicine; Science: Biology (General): Genetics; Medicine: Internal medicine

Materias / palabras clave: genetics, genetic mechanisms of disease, statistical genetics, next-generation sequencing; Science: Biology (General): Genetics

Materias / palabras clave: genetics, inborn errors, biochemics, molecular genetics, inherited metabolic disorders; Medicine: Internal medicine: Specialties of internal medicine: Diseases of the endocrine glands. Clinical endocrinology; Science: Bi...