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Tesis de Doctorado Las células folículo-estrelladas (CFE) son una población celular no-endocrina de la adenohipófisis, caracterizada por su fenotipo estrellado y largas prolongaciones citoplasmáticas que forman una ...

The Central Brain Tumor Registry of the United States (CBTRUS), in collaboration with the CDC and NCI, is the largest population-based registry focused exclusively on primary brain and other central nervous system (CNS) ...

Anticancer cytotoxic agents go through a process by which their antitumor activity-on the basis of the amount of tumor shrinkage they could generate-has been investigated. In the late 1970s, the International Union Again...

The fifth edition of the WHO Classification of Tumors of the Central Nervous System (CNS), published in 2021, is the sixth version of the international standard for the classification of brain and spinal cord tumors. Bui...

Como numerosos procesos biológicos, la proliferación de diversas poblaciones celulares animales presenta un ritmo circadiano. La respuesta diferencial a la ciclofosfamida ha sido relacionada con la periodicidad mitóti...

Keyuan Zhao,1 Yanjiao Jiang2 1The Second School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, 310053, People’s Republic of China; 2The Second Affiliated Hospital of Zhejiang Chinese Med...

Two adult domestic shorthair cats were evaluated for progressive neurologic deficits caused by spinal cord compression secondary to vertebral osteosarcoma, giant-cell subtype. Feline giant cell osteosarcoma represents a ...

Abstract Background Gliomas in dogs remain poorly understood. Objectives To characterize the clinicopathologic findings, diagnostic imaging features and survival of a large sample of dogs with glioma using the Comparativ...

Abstract Background The tumor microenvironment of oropharyngeal squamous cell carcinoma (OPSCC) harbors diverse immune cell populations that influence tumor progression and patient outcome. Materials In 102 surgically tr...

Abstract Background Sarcomas are a heterogeneous group of mesenchymal malignancies with diverse histological subtypes, limited treatment options, and generally poor outcomes in advanced disease. EXT2, a glycosyltransfera...

Abstract Background The high doses of radioiodine‐131 (131I) and, subsequently, the high radioactive burden for dog and environment warrants optimization of 131I therapy in dogs with thyroid carcinoma (TC). Hypothesis/...

Abstract Background The tumor immune microenvironment (TIME) of canine and feline mammary carcinomas (CMC and FMC) comprises a complex collection of immune cells that remains underinvestigated. We performed extensive imm...

Emmanuel Ifeanyi Obeagu1– 3 1Division of Haematology, Department of Biomedical and Laboratory Science, Africa University Mutare, Mutare, Zimbabwe; 2Department of Molecular Medicine and Haematology, School of Pathology,...

BackgroundMacrophage polarization plays a critical role in shaping the immunosuppressive tumor microenvironment (TME) of prostate cancer (PCa). Tumor-associated macrophages (TAMs), particularly those exhibiting immunoreg...

Jiawei Zhao,1,* Yuting Gou,1,* Yiyang Wang,1,* Yongxiang Li,1 Haotian Ma,1 Yiting Xing,2 Haohao Peng,2 Chenming Guo1,3 1Department of Breast Surgery, Center of Digestive and Vascular, The First Af...

Bladder cancer is a highly malignant tumor with limited treatment options. Although adoptive cell therapy has shown promise in oncology, its efficacy is often constrained by poor intrinsic antitumor activity and a highly...

In this paper we investigated whether protein kinase C (PKC) b1 and PKCe, members of the classical and novel PKC family respectively, induce phenotypic alterations that could be associated with tumor progression and meta...

Tumor metastasis is the leading cause of mortality in patients with malignant cancers, and the establishment of the pre-metastatic niche (PMN) is recognized as a pivotal step in this process. With growing insight into th...

Abstract Histone deacetylases (HDACs) are critical epigenetic regulators that play pivotal roles in tumorigenesis and cancer progression. Class I HDACs have garnered significant attention due to their essential functions...

Abstract Background Treatment of head and neck squamous cell carcinoma (HNSCC) remains challenging and the survival rates of affected patients remain poor. A three-dimensional organotypic co-culture (3D-OTC) model where ...

Photodynamic priming (PDP), a collateral effect of photodynamic therapy, can transiently alter the tumor microenvironment (TME) beyond the cytotoxic zone. Studies have demonstrated that PDP increases tumor permeability a...

Latar Belakang: Pleomorfik adenoma (mixed tumor) adalah tumor kelenjar ludah yang paling sering terjadi (65%) pada kelenjar ludah mayor dan minor. Lokasi intraoral yang paling sering ditemukan adalah palatum. Tujuan: mem...

The failure of immunotherapies in cancer patients is being widely studied due to the complexitiespresent in the tumor microenvironment (TME), where regulatory T cells (Treg) appear toactively participate in providing an ...

Small cell lung cancer (SCLC) remains one of the most aggressive malignancies, characterized by rapid proliferation, early metastatic dissemination, and poor long-term survival despite initial sensitivity to therapy. SCL...