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IntroductionThe MIRACLE Task Force is a multidisciplinary, multi-institutional work group comprising immunology, genetics, obstetrics/gynecology, and maternal fetal medicine providers dedicated to understanding reproduct...

Abstract Background Most households in developing countries like India are not able to afford to get the services of efficient energy for cooking and lighting. Therefore, they rely mostly on solid fuels (firewood, dung c...

Allergic rhinitis (AR), asthma, and their combined allergic rhinitis and asthma syndrome (CARAS) frequently coexist. However, the underlying pathophysiological and metabolic mechanisms, as well as reliable diagnostic dif...

BackgroundN-acetylcysteine (NAC) is a key precursor of glutathione (GSH), the lung’s principal antioxidant. First developed as a mucolytic, NAC is now recognized for broader antioxidant, anti-inflammatory, immunomodula...

Pothos scandens, belonging to the Araceae family, locally known as “batilata,” is traditionally used for treating various chronic diseases in folk medicine, such as epilepsy, seizures, convulsions, wounds, snakebites...

Immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome is a monogenic disorder caused by loss-of-function mutations in the FOXP3 gene, which is critical for the development of functional regulato...

Background and objective: Validity of continuous variable test like total serum IgE is performed by constructing Receiver Operating Characteristic (ROC) curve. ROC curve is a technique for visualizing, organizing and sel...

Abstract Chronic respiratory diseases (CRDs), particularly asthma and chronic obstructive pulmonary disease (COPD), impose significant burdens on patients and their families in low- and middle-income countries (LMICs). L...

Abstract Objective The present comprehensive review aims to show the full extent of what is known to date and provide a more thorough view on the effects of SARS-CoV2 in pregnancy. Methods Between March 29 and May, 2...

The IKAROS family of zinc finger transcription factors (IKZF1–4) plays a central role in lymphocyte development and immune regulation. Pathogenic IKZF1 variants produce a wide phenotypic spectrum related to whether the...

Background22q11.2 deletion syndrome (DS) is the most common chromosomal microdeletion syndrome and a leading cause of developmental delay, congenital heart disease, and varying degrees of T cell immunodeficiency. While m...

BackgroundDominant-negative (DN) STAT3 defects (STAT3-DN) result in >75% loss of STAT3 function and lead to autosomal-dominant hyper-IgE syndrome (HIES) characterized by severe eczema, recurrent bacterial and fungal infe...

This guideline is the result of a systematic literature review using the ‘Grading of Recommendations Assessment, Development and Evaluation’ (GRADE) methodology and a structured consensus conference held on 28 and 29...

Introduction: In recent years, the prevalence of atopic diseases among children has increased. Increasing evidence suggests that early gut microbiota development, shaped in part by the mode of delivery, feeding practices...

Extreme heat is a significant direct health threat from climate change, with rising temperatures and frequent heatwaves increasingly stressing communities and health services across Africa. High baseline temperatures, wi...

Abstract Hereditary angioedema (HAE) is a rare, potentially life-threatening genetic disorder characterized by recurrent subcutaneous and/or submucosal edema, most commonly caused by deficiency in C1-esterase inhibitor. ...

Abstract This update to the 2019 Canadian Hereditary Angioedema (HAE) Guideline broadens its focus to include the management of patients with HAE worldwide, building on its established international framework. It has bee...

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This is a document produced by a joint ATS-ERS Task Force on lung function testing to provide new combined standards for Spirometry. It walks the reader through all the important elements of the test, from instrument to ...

No Nordeste do Brasil a casca de Amburana cearensis (Fr. All.) A.C. Smith (Fabaceae) é utilizada na medicina popular no tratamento de afecções do trato respiratório. O trabalho objetivou avaliar o efeito imunomodulad...

Calotropis gigantea (Linn.) R.Br. (Asclepiadaceae), commonly known as milkweed or swallow- wort, is found chiefly in wasteland throughout India. It has been reported as a traditional folkloric medicine in treatment of as...

The aim of the present study was to determine the antiallergic and anti-inflammatory properties of the methanolic extract from stem bark of Ailanthus excelsa Roxb (AEME). Herbal medicines are assuming greater importance ...