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O interesse na aplicação de sistemas nanoestrurados como veículo de preparações farmacêuticas se deve a capacidade destes de solubilizar substâncias hidrofílicas e lipofílicas. Com isto, têm sido utilizados vis...

A qualidade de formulações manipuladas é conseqüência direta da qualidade da matéria-prima empregada para sua obtenção. Dessa forma, características físico-químicas relacionados ao fármaco tais como tamanho d...

Los mayores obstáculos para la toma de decisiones en bioequivalencia promedio están referidos al tamaño de la variabilidad residual. Se ha visto que en ella incide mucho las características de los individuos reclut...

Rhizoma Paridis saponins (RPS) were considered to be the principal bioactive components of Paris polyphylla Smith var. yunnanensis. Intestinal microflora-mediated metabolism may affect their pharmacological activities in...

La optimización de los preparados farmacéuticos para su administración al organismo constituye uno de los objetivos fundamentales de la biofarmacia. El diseño de un preparado farmacéutico es un problema de gran comp...

The objective of this study was to compare the pharmacokinetic characteristics of ascaridole following oral administration of pure ascaridole and Jinghuaweikang (JHWK) capsule. Besides, additional rats were given pure as...

B-lapachona é uma ortonaftoquinona natural do ipê roxo crescente principalmente no Brasil, obtida também pelo processo de semissíntese do seu isômero Lapachol. É um produto vegetal simples que tem demonstrado exc...

The present investigation concerns the development of floating tablets of tramadol hydrochloride, which after oral administration are designed to prolong the gastric residence time; improves the drug bioavailability, red...

The aim of the present study was to develop sustained release swelling tablets containing metformin HCl and confine them into the stomach for enhancement of bioavailability. The different batches were manufactured by wet...

Effervescent tablets have always been convenient, simple and measured dosage form. The phenomenon of carbonation, in this type of dosage form, accelerates the solubility and enhances the bioavailability of the drug and t...

The aim of this study was to develop sustained release formulation for improving bioavailability of metronidazole designing metronidazole loaded chitosan microcapsules (MLCM) using coacervation technique. Two solutions w...

The present investigation concerns the development of a floating matrix tablet, which after oral administration prolong the gastric residence time and increases bioavailability of drugs, which are predominantly absorbed ...

Fenofibrate is more effective drug as compared to other fibrates. But low bioavailability of it is due to its poor aqueous solubility. The purpose of present study was to improve fenofibrate dissolution through its formu...

Se analizó el efecto de un aglutinante, polivinilpirrolidona (PVP), y de un desintegrante, almidón,sobre el proceso de disolución de comprimidos de paracetamol, calculándose una serie de parámetros cinéticos con el...

Se presenta un estudio de bioequivalencia de dos formas farmacéuticas de Teofilina de liberación prolongada, teniendo en cuenta la cinética no lineal de eliminación de esta droga. Una dosis de 300 mg de Teofilina fue...

Se han estudiado los efectos de los complejos zinc-metionina con la relación molar 1:1 y 1:2 como suplementación alimentaria de zinc en ratones. La obtención y la caracterización de dos complejos de zinc fueron evalu...

Con el objeto de evaluar comparativamente características de calidad de comprimidos de paracetamol de 500 mg, se estudiaron caracteres posológicos, mecánicos y de biodisponibilidad de 10 marcas comerciales diferente...

The purpose of this research was to formulate fast-disintegrating tablets of famotidine by using tasteless complex of famotidine. Famotidine is a commonly used antiulcer drug but major disadvantage is its bitterness an...

The prolonged residence of drug formulation in the nasal cavity is of utmost importance for intranasal drug delivery. The objective of the present investigation was to develop a mucoadhesive in situ gel with reduced nasa...

The aim of the present investigation was to develop a modified release effervescent floating drug delivery system of famotidine for 12 h dosage regimen to improve its bioavailability. Effervescent floating tablets were...

O objetivo deste trabalho foi avaliar a influência da força de compressão e da umidade no perfil de dissolução de uma formulação de comprimidos. Por apresentar problemas reais de biodisponibilidade a hidroclorotia...

The purpose of the present study was to develop and optimize floating-bioadhesive bilayer gastroretentive drug delivery system (GRDDS) exhibiting a unique combination of floatation and bioadhesion to prolong residence ...

Repaglinide (RGL) loaded polymeric drug delivery devices like microcapsules (MC) and transdermal patches (TDP) were formulated and there in vitro-in vivo parameters compared to find out the best route of drug delivery. T...

Nanoparticles are widely utilized to overcome drugs insolubility problems and sustain release improving the bioavailability. Zinc phthalocyanine, a hydrophobic photosensitizer with solubility problems, was loaded in PLA ...