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Abstract Nuclear pore complexes serve as essential gatekeepers of the nuclear envelope, playing crucial roles in regulating transport across the nuclear envelope and maintaining compartmentalization between the nucleus a...

Peritonitis is one of the leading cause of hospitalization in peritoneal dialysis patients. Although inflammatory markers show an increased inflammatory response, cellular immune response is decreased in ESRD patients. U...

Increased levels of α-synuclein (α-syn) and iron-overload are pathognomonic signs of dopaminergic neurons in Parkinson’s disease (PD) patients. Moreover, iron and fatty acid (FA) availability are predisposing factors...

Abstract Mosaic variegated aneuploidy (MVA), a rare human congenital disorder that causes microcephaly, is characterized by extensive abnormalities in chromosome number and results from mutations in genes involved in acc...

OBJECTIVE: Rapidly progressive glomerulonephritis is associated with rapid deterioration of kidney function. We aimed to evaluate patients followed-up with the diagnosis of rapidly progressive glomerulonephritis. MATE...

Abstract Since the first report in 1972, several studies have documented an association between Parkinson’s disease (PD) and melanoma. Up to 20-fold increased risk of melanoma was reported in PD patients, while a perso...

ABSTRACT Cells rely on surface receptors to sense and initiate signalling cascades essential for numerous cellular processes, but engineering of synthetic genetic circuits to sense and rewire receptor activities for user...

Abstract Fish consumption plays an important role in human diet. Hoplias malabaricus, commonly known as traíra, is a freshwater fish widely appreciated in several Brazilian states and frequently infected by Eustrongylid...

Abstract Sirtuin 1 has an important role in cellular processes, including apoptosis and cellular stress. The purpose of this study was to assess serum sirtuin 1 levels in women with recurrent implantation failure (RIF). ...

STAT3 signaling is fundamental to T cells, where it underlies basic cellular processes like metabolism and apoptosis, as well as specialized processes like effector differentiation and cytokine production. However, mutat...

Abstract Microtubules perform a variety of cellular functions, including regulation of mitotic cell division, cilia formation, and neurite extension. Post-translational modifications controlled by the TTLL-family of enzy...

BackgroundThe ubiquitin–proteasome pathway is a critical therapeutic target in malignancies, particularly multiple myeloma. The development of proteasome inhibitors (PIs) has marked a milestone in multiple myeloma ther...

We report the synthesis and biological evaluation of a ternary copper complex, [Cu(5HTP)(phen)(H2O)](NO3).2H2O, with the antioxidant agent 5-hydroxytryptophan (5-HTP) and phenanthroline (phen, added to improve its lipoph...

ABSTRACT Background Intervertebral disc degeneration (IVDD), a prevalent spinal disorder, is closely associated with abnormal mechanical stress. The nucleus pulposus (NP), annulus fibrosus (AF), and cartilaginous endplat...

This work explores the intricate process of osmoregulation in Trypanosoma cruzi, the causative agent of Chagas disease, with a specific focus on the mechanisms of fluid discharge by the contractile vacuole complex (CVC) ...

Background: Phytolacca tetramera is an endemic plant from Argentina that is currently at serious risk because its environment is subjected to a high anthropic impact. A previous study has shown that berry extracts obtain...

Abstract Targeting the BCL-2 family of proteins, key regulators of cellular apoptosis, with BH3-mimetics has been a major therapeutic goal to overcome cancer cell death resistance. However, beyond their canonical roles i...

c-Jun is a member of the early mammalian transcriptional regulators belonging to the AP-1 family, which participates in a wide range of cellular processes such as proliferation, apoptosis, tumorigenesis, and differentiat...

Abstract Single-cell RNA sequencing (scRNA-seq) has revolutionized our understanding of cellular heterogeneity in complex biological systems. However, analyzing and integrating scRNA-seq data poses unique computational c...

The rapidly expanding technology of cellular communications, wireless local area network (LAN), wireless data networks and satellite gives mobile users the ability of accessing information anywhere and anytime. Data broa...

En la presente revisión se brinda información sobre lectinas de plantas celulares y vasculares. En particular se discute la defmición de lectinas, su estructura, especificidad sacarídica, localización y funciones bi...

El cromo, al estado trivalente, es un elemento ultra-traza esencial, mientras que, por otro lado, la mutagenicidad y carcinogenicidad está bien establecida en sistemas biológicos para estados de oxidación superiores. ...

The present study was undertaken to evaluate immunomodulatory activity of Crocus sativus and its active constituent crocin. Crocus sativus and crocin were administered orally at doses of 50 mg/kg and 9.69 mg/kg, respec...

Mechanotransduction is a process where cells sense their surroundings and convert the physical forces in their environment into an appropriate response. Calcium plays a crucial role in the translation of such forces to b...