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Background: Liver hepatocellular carcinoma is a highly prevalent and lethal malignancy. The orphan cytokine receptor-like factor 3, although evolutionarily conserved and implicated in hematopoiesis and neuroprotection, r...

الملخص: أهداف البحث: تم التعرف على ما لا يقل عن 500 شكل جيني متعدد مرتبط بإنزيمي CYP2C19 وCYP2C18، إلا أن عددا قليلا من هذه الأشكال...

The root-lesion nematode Pratylenchus vulnus parasitizes a wide range of hosts, including woody perennials such as walnut (Juglans regia) and grapevine (Vitis vinifera), significantly damaging roots and reducing yields. ...

Abstract Objective This study aimed to systematically identify and validate KIF15 as a potential diagnostic and prognostic biomarker in colon cancer (CC) using integrated bioinformatics analyses. We further explored its ...

Xue Fu,1 Jiawei Dong,2 Jian Yang,2 Xiaotian Zhang,2 Shangkun Cai,2 Yiwei Zhang,2 Shenglong Lv,2 Meng Zhang2 1Department of Emergency, Hebei Medical University Third Hospital, Shijiazhuang, 050051, People’s Republic of ...

Background: Barrett's esophagus (BE) represents a critical precancerous lesion arising from chronic gastroesophageal reflux disease (GERD), with significant risk of progression to esophageal adenocarcinoma. Despite advan...

Objetivou-se mapear QTL nos cromossomos 5, 7 e 8 e associá-los a características de carcaça, cortes de carcaça, qualidade de carne, desempenho e órgãos internos de suínos. Uma progênie F2 de 614 animais foi produ...

Over the past three decades, a new picture of our own ancestral past has emerged through the elucidation of the complex genetic relationships between Neanderthals, Denisovans, and modern humans by the direct analysis of ...

ObjectiveTo investigate the antimicrobial resistance characteristics of Salmonella spp. isolated from retail whole chickens in Beijing， analyze the prevalence and genomic characteristics of cefotaxime （CTX）-resista...

The Phaffia rhodozyma UCD 67-385 genome harbors a 7873 bp cluster containing DDGS, OMT, and ATPG, encoding 2-desmethy-4-deoxygadusol synthase, O-methyl transferase, and ATPgrasp ligase, respectively, of the mycosporine g...

Materias / palabras clave: Arabidopsis; Genome; Biology; Gene; Genetics; Arabidopsis thaliana; Multicellular organism; Gene family; Caenorhabditis elegans; Gene duplication; Computational biology; Mutant

There is increasing evidence that genome-wide association (GWA) studies represent a powerful approach to the identification of genes involved in common human diseases. We describe a joint GWA study (using the Affymetrix ...

A system of cluster analysis for genome-wide expression data from DNA microarray hybridization is described that uses standard statistical algorithms to arrange genes according to similarity in pattern of gene expression...

Materias / palabras clave: Population stratification; Spurious relationship; Biology; Principal component analysis; Allele frequency; Genetic association; Genome-wide association study; Population; Evolutionary biology; Computational biology; Geno...

Although genomewide RNA expression analysis has become a routine tool in biomedical research, extracting biological insight from such information remains a major challenge. Here, we describe a powerful analytical method ...

The human genome holds an extraordinary trove of information about human development, physiology, medicine and evolution. Here we report the results of an international collaboration to produce and make freely available ...

Current clinical practice is organized according to tissue or organ of origin of tumors. Now, The Cancer Genome Atlas (TCGA) Research Network has started to identify genomic and other molecular commonalities among a doze...

Materias / palabras clave: Genome-wide association study; Heritability; Missing heritability problem; Genetic association; Quantitative trait locus; Single-nucleotide polymorphism; Linkage disequilibrium; Trait; Genetics; Biology; Computer science...

Proteins and their functional interactions form the backbone of the cellular machinery. Their connectivity network needs to be considered for the full understanding of biological phenomena, but the available information ...

Materias / palabras clave: Computational biology; Bioconductor; RNA-Seq; Sequence assembly; Workflow; Transcriptome; Biology; De novo transcriptome assembly; Genome; Reference genome; Computer science; Sequence analysis

MOTIVATION: DnaSP is a software package for a comprehensive analysis of DNA polymorphism data. Version 5 implements a number of new features and analytical methods allowing extensive DNA polymorphism analyses on large da...

Enrichment analysis is a popular method for analyzing gene sets generated by genome-wide experiments. Here we present a significant update to one of the tools in this domain called Enrichr. Enrichr currently contains a l...

Kyoto Encyclopedia of Genes and Genomes (KEGG) is a knowledge base for systematic analysis of gene functions in terms of the networks of genes and molecules. The major component of KEGG is the PATHWAY database that consi...

KEGG (Kyoto Encyclopedia of Genes and Genomes) is a knowledge base for systematic analysis of gene functions, linking genomic information with higher order functional information. The genomic information is stored in the...