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O principal objetivo deste trabalho foi desenvolver sistemas matriciais obtidos da mistura pectina/ HPMC e lactose/HPMC como polímeros capazes de modular a liberação colônica de quercetina. Os comprimidos matriciai...

O captopril foi previamente revestido em leito fluidizado com os polímeros etilcelulose, metilcelulose e polivinilpirrolidona. A partir dos grânulos formados foram desenvolvidos comprimidos de liberação prolongada e ...

The objective of the present research was to develop acyclovir ophthalmic emulgels using different polymers such as Pluronic F 127 (PF 127), Gelrite, Carbopol 934P, hydroxypropylmethylcellulose (HPMC K100M) and sodium ca...

The present investigation concerns the development of mucoadhesive tablets of captopril which were designed to prolong the gastric residence time after oral administration. Matrix tablets of captopril were formulated u...

The present study evaluated novel polymer mixtures prepared by spray drying of an aqueous dispersion of moth bean starch with Carbopol 934P and HPMC K4M for to be used as platform for peroral mucoadhesive drug delivery...

The purpose of this paper was to produce controlled-release matrices with 120 mg of propranolol hydrochloride (PHCl) employing hydroxypropyl methylcellulose (HPMC, Methocel® K100) as the gel forming barrier. Although th...

The aim of the present study is to prepare bilayered floating tablets of diltiazem with different ratios of polymers like HPMC K4M, carbopol 934 P, sodium alginate, Plantago ovata seed husk (psyllium) and to carry out ev...

The present study was undertaken to evaluate the effect of glyceryl monostearate (GMS) and stearic acid (SA) on the release profile of gliclazide from the matrix. Matrix tablets for the controlled delivery of gliclazide ...

The aim of the present investigation is to improve the dissolution of poorly water soluble drug valsartan by preparing solid dispersions and also to evaluate the effect of different inert carriers on flow properties of s...

Nimesulide was formulated as novel dual coated microparticles using chitosan (CTN) and ethyl cellulose (EC) as encapsulating materials for its improved delivery to the intestine and to prevent gastric irritation and incr...

Os polihidroxialcanoatos são poliésteres de hidroxiácidos sintetizados por inúmeras bactérias, como compostos que servem como fonte de carbono intracelular e energia, sendo acumulados na forma de grânulos no cito...

Eugenol (4-allyl-2-methoxyphenol) is a naturally occurring phenol present in many botanical extracts, such as clove, cinnamon, and nutmeg essential oils. The beneficial properties of this compound have been extensively i...

Implants prepared with polymer blends [poly (e-caprolactone)-poly(lactide), PCL-PLA] at different rates were developed from microspheres. Approximately 19% of dexamethasone acetate was encapsulated into the microsphere...

Spherical crystallization (SC) is a promising alternative for improiving micromeritic properties and dissolution rate of active pharmaceutical ingredients. In the present work spherical agglomerates of carvedilol (CAR) w...

To select the suitable concentration level of controlled release polymer for the formulation of predefined extended release formulation based on the solubility behaviour of active substance, we have formulated and evalua...

The purpose of the present research work was to produce a biphasic delivery system for Diclofenac sodium. A dual component tablet made up of a sustained release beads and immediate release tablet coat was prepared by dir...

Oral route of drug administration is the most preferred route of drug administration but this route has its own limitations like pH of gastric media and controlling release rate of water soluble drug. To overcome these l...

The purpose of this work was to design and evaluate a novel vaginal delivery system for the local treatment of vaginal candidiasis. Bioadhesive vaginal films of metronidazole that could be retained in the vagina for prol...

The purpose of this study was to design a novel vaginal delivery system composed of metronidazole microspheres dispersed within a bioadhesive gel. Microspheres were prepared by solvent evaporation method using Eudragit...

The aim of the present study was to develop a sustained release mucoadhesive buccal film of naproxen, which can be used to treat the inflammation in the oral cavity. The mucoadhesive buccal films were prepared by solve...

Las semillas de Cucurbita pepo L., por su elevado porcentaje de aceite fijo, son ricas en ácidos grasos poliinsaturados, fitoesteroles, tocoferoles y carotenoides, empleándose tradicionalmente como antiinflamatorio en ...

En los últimos años, se ha desarrollado un gran interés por la producción de polímeros denominados funcionales o specialties. Los mismos se destacan por poseer algunas propiedades particulares que dan lugar a aplica...

Se estudiaron las variaciones en el perfil de polifenoles de Tripodanthus acutifolius (Ruiz et Pav.) Tiegh., en relación con la infección causada por "cochinilla", analizando comparativamente los extractos metanólico...

The aim of the study was to formulate and evaluate controlled release microspheres. Ciprofloxacin HCl, belonging to the class of fluroquinolones, was chosen as the model drug. The drugloaded microspheres were prepared wi...