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Abstract Under high-altitude hypoxia, neuroinflammation contributes to cognitive impairment, though the underlying mechanisms remain unclear. In this study, we established rat and astrocyte models of hypoxic exposure. We...

Abstract Background Mild cognitive impairment (MCI) is an intermediate stage between normal cognitive aging and dementia. People with MCI have a higher risk of developing dementia than normal healthy people. Improving th...

Abstract Background Subjective cognitive decline and mild cognitive impairment represent critical windows for intervention as early stages of dementia progression. Although digital health interventions have shown potenti...

Abstract Background Physical exercise has emerged as a promising non-pharmacological approach for improving cognitive and physical function in older adults with mild cognitive impairment (MCI). However, most existing int...

Abstract Background Therapeutic Communities (TCs) are long-term residential treatment settings for individuals with substance use disorders, who often present with neuropsychological impairments. These impairments may in...

Abstract Postoperative neurocognitive disorder (PND) is a frequent complication in elderly surgical patients and is closely associated with blood-brain barrier (BBB) disruption and cerebral metabolic imbalance. The prese...

Abstract Background Migraine with aura is clinically linked to cognitive impairment, yet sex differences and underlying mechanisms are unclear. Cortical spreading depression (CSD) is widely regarded as the electrophysiol...

Abstract Background Fatigue is the main complaint of 5–10% of patients in primary care and is often associated with significant suffering and functional disability. Cognitive behavioral therapy (CBT) has demonstrated e...

Abstract Background Coenzyme Q10 (CoQ10) is a key mitochondrial electron carrier and a widely used dietary supplement with potential neurological benefits. However, the mechanisms underlying its effect in ameliorating me...

Abstract Background Sarcopenia, altered bone and systemic metabolism, physical frailty and cognitive decline are age-dependent and interrelated phenomena. Sleep disorders which are erroneously considered as part of the a...

Abstract Background Hypothalamic phospholipids, essential components of neuronal membranes, play a key role in neuroendocrine regulation and synaptic plasticity. Liposom Forte, an injectable formulation based on hypothal...

Abstract Background Obesity has emerged as a major global health issue, affecting multiple organ systems. Within the central nervous system obesity causes a series of disruptions that can significantly affect neurologica...

Abstract Purpose This study aimed to investigate sleep patterns in children with severe medical complexity (CMC) eligible for pediatric palliative care (PPC) and to evaluate the specific impact of these patterns on their...

Abstract Background Bipolar disorder (BD) typically emerges during adolescence and is associated with substantial functional impairment, but objective physiological markers are scarce. The niacin skin flushing response (...

Abstract Purpose This study aimed to identify the effectiveness of free water MRI (FW-MRI) features for predicting amyloid-beta (Aβ) statuses in Alzheimer’s disease (AD) by constructing diagnostic models using machine...

Abstract Background Proper eating/fasting cycle can regulate circadian rhythms, thereby influencing metabolic regulation, oxidative stress, and cognitive function. However, its association with overall health remains und...

Abstract Background Recruitment and retention remain persistent challenges in Alzheimer’s disease (AD) clinical trials, particularly as studies increasingly focus on earlier disease stages and require longer participat...

Abstract Background Chronic Insomnia Disorder (CID) is a prevalent condition. This study examines microbaric oxygen therapy (MOT) as a non-pharmacological intervention for CID patients, utilizing EEG to investigate its e...

Abstract Background Thailand is undergoing a rapid demographic transition toward an aging society, with substantial challenges in ensuring health equity for older adults. While national-level health policies have expande...

Abstract Background Since 1990, the survival rate of very preterm (VP) infants (born 

Abstract Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused a major global health burden in terms of acute infection and long-term consequences. Approx...

Abstract Background and objectives The under-representation of vulnerable groups in clinical trials, including persons with disabilities, could affect the applicability of trial findings to real-world public health inter...