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Abstract Background ADAM10 and ADAM17, members of the membrane-bound disintegrin metalloproteinase (ADAM) family, act as α-secretases in the non-amyloidogenic processing of the amyloid precursor protein. While alteratio...

Abstract Background Spontaneous intracranial hypotension (SIH) is an underrecognized condition with rapidly evolving diagnostic and therapeutic strategies. This study investigated temporal and regional trends in diagnost...

Abstract Background Blood-based biomarkers could improve the precision of Alzheimer’s disease (AD) clinical diagnosis and expand access to targeted treatments. Therefore, we evaluated the diagnostic accuracy of plasma ...

Abstract Background As cases of neurosyphilis are rising worldwide – especially in people living with HIV (PLWH) – current data on clinical presentation, diagnostics and management of neurosyphilis in Europe are of h...

Abstract Background Plasma glial fibrillary acidic protein (GFAP) has emerged as a promising biomarker of astrocytic reactivity in preclinical Alzheimer´s Disease (AD). However, most evidence to date comes from ultrasen...

Abstract Objective Cerebrospinal fluid (CSF) over-drainage is an unintended sequela of using a shunt valve to treat hydrocephalus, and a second valve may be added in series to better control drainage. In this study, we t...

Abstract Ventricular shunt catheters are the standard of care for managing hydrocephalus, yet 40% of implanted catheters fail within two years of implantation, mainly due to proximal catheter obstruction. Prior literatur...

Abstract Background While Canadian First Nations communities actively participate in sport, cultural, and land-based activities, they face various barriers to physical activity. Despite calls for increased support at all...