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Vascular and metabolic diseases, including atherosclerosis, aortic aneurysm and dissection, obesity, type 2 diabetes, and metabolic dysfunction–associated steatotic liver disease (MASLD), constitute a major global heal...

Mitochondrial dysfunction can lead to the accumulation of fatty acids and excessive production of reactive oxygen species (ROS), ultimately resulting in impaired energy production. Carnitine is essential for transporting...

Parabens, ubiquitous preservatives with endocrine-disrupting potential, may adversely affect mental and cardiometabolic health, but evidence in elderly populations is limited. This study aimed to explore the relationship...

Metabolic dysfunction-associated steatohepatitis (MASH) represents a growing global health challenge due to its propensity to progress to irreversible hepatic disorders, including fibrosis, cirrhosis, and carcinoma. This...

The peroxisome proliferator-activated receptors (PPARs), including PPAR-α, PPAR-β/δ, and PPAR-γ, are nuclear receptors that play critical roles in regulating metabolism and inflammation. While PPARs have been extensi...

The gut microbiota has co-evolved with its host and forms an essential component of the human body. It is acquired at birth and continues to develop alongside the host, preserving its diversity and stability throughout l...

Phthalate plasticizers, especially diethyl phthalate (DEP), are linked to metabolic disorders, while their precise role and mechanism in diabetic nephropathy (DN) pathogenesis remain unclear. Here, we integrated transcri...

The incidence of metabolic disorders including obesity, type 2 diabetes and metabolic syndrome have seriously increased in the last decades. These diseases - with growing impact in modern societies - constitute major ris...

Background: The progression of pulpitis is strongly affected by the fate of dental pulp cells, with their modes of cell death determining whether inflammation resolves or leads to irreversible necrosis. Cuproptosis, a co...

Coenzyme A (CoA) is a vital cofactor involved in energy metabolism, lipid biosynthesis, protein modification, and epigenetic regulation. Disruptions in CoA biosynthesis have been implicated in neurometabolic disorders su...

Background: Perthes disease, also known as Legg-Calvé-Perthes disease (LCPD), is a paediatric orthopaedic condition that compromises the blood flow to the hip joint causing avascular necrosis of the femoral head affecti...

Hepatic manifestations of type 2 diabetes, including steatosis, represent a major complication driven by hepatic lipotoxicity and ceramide accumulation, yet few targeted interventions are available. This study investigat...

Soybeans hold a deep cultural significance with its origin in Asia. All of the current modern cultivars belong to the same Glycine max (L.) Merrill, which can be distinguished primarily by their seed coat pigmentation. T...

Microplastics (MPs), environmental pollutants resulting from the degradation of plastic products and industrial processes, have become ubiquitous in global ecosystems. MPs can enter the human body through ingestion, inha...

Globally, one major cause of morbidity and mortality is cardiovascular diseases (CVDs). The burden of cardiovascular disease among the elderly is still high and typically tends to move to nations with lower sociodemograp...

Background: Trapezius myalgia (TM) is a prevalent condition characterized by upper back and neck pain, commonly affecting those engaged in prolonged desk work, repetitive overhead activity, or manual labour. The conditio...