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Aging is a complex biological process characterized by progressive functional decline and increased vulnerability to age-related diseases, particularly neurodegenerative disorders. At the biological level, aging is chara...

BackgroundAlzheimer’s disease (AD), the most prevalent dementia, is primarily underpinned by the amyloid cascade hypothesis. Passive Aβ immunotherapy effectively reduces cerebral Aβ deposition but is limited by sever...

ObjectiveTo investigate the prognostic value of blood pressure variability (BPV) combined with serum tau protein in patients with traumatic brain injury (TBI).MethodsA total of 205 TBI patients were prospectively enrolle...

The precise treatment and dynamic management of traumatic brain injury pose a substantial challenge to the global healthcare sector. This challenge arises not only from the complex and dynamically evolving pathological m...

BackgroundAttention deficits often persist after mild traumatic brain injury (mTBI), limiting recovery despite normal imaging. Transcranial direct current stimulation (tDCS) has emerged as a non-invasive therapeutic opti...

IntroductionAquatic light environments are increasingly altered by human activity, yet the endocrine and molecular mechanisms enabling fish to cope with extreme photoperiods remain poorly understood. This study investiga...

Materias / palabras clave: artificial intelligence; global health; health disparities; low and mid income countries; neurological disorder; nueroimaging

In the central nervous system (CNS), programmed cell death (PCD) of neurons, is precisely regulated by various biomolecules to maintain neuronal development, establish neural structures, and maintain CNS homeostasis. Und...

ObjectiveChronic pain, a major global public health burden, is primarily driven by altered central pain processing, which conventional treatments rarely target directly. This systematic review and meta-analysis synthesiz...

IntroductionRecent research has highlighted the role of the gut microbiome in shaping the development and function of the mammalian immune system. Interactions between these complex networks of microbes and host cells se...

The transition to active rehabilitation in concussion care requires precise tools to identify patients at risk of persistent post-concussive symptoms (PPCS). While machine learning (ML) offers the potential to personaliz...

IntroductionSouth American camelids (SACs) and dromedaries presenting with neurological abnormalities are increasingly common in veterinary practice. Advanced diagnostic imaging techniques, such as computed tomography (C...

Autism spectrum disorders (ASDs) are neuropsychiatric diseases characterized by impaired social interaction, communication deficits, and repetitive and stereotyped behaviors. ASD etiology is unknown, and both genetic and...

BackgroundCurrent prognostic models for cerebral venous sinus thrombosis (CVST) inadequately predict long-term cognitive and functional outcomes, focusing primarily on survival. We aimed to develop and validate a simple,...

As the prevalence of chronic rhinosinusitis (CRS) and allergic rhinitis (AR) continues to rise worldwide, more and more patients are reporting a lower quality of life. In addition to causing common nasal symptoms such as...

Glioblastoma is the most common and aggressive primary brain tumor in adults that fails to meet survival endpoint criteria in current immunotherapy Phase III clinical trials. As a small subset of immunotherapy-responsive...

Osteoporosis (OP), a widespread metabolic bone condition characterized by diminished bone mass and compromised microarchitecture, poses a significant global health challenge. The gut microbiota (GM) regulates bone homeos...

Post-stroke cognitive impairment (PSCI) has garnered widespread attention due to its high incidence and its association with increased risk of stroke recurrence and mortality. Growing evidence indicates that early predic...

BackgroundSleep disruption(SD) has been shown to amplify inflammatory signaling and promote pain hypersensitivity, but how inflammation interacts with brain functional alterations to drive pain sensitization remains uncl...

IntroductionParkinson’s disease (PD) is a progressive neurodegenerative disorder for which there is no cure. Diabetes is one of the risk factors for developing PD. Tirzepatide is a novel long-acting glucagon-like pepti...