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Sepsis remains a major challenge in critical care medicine worldwide, characterized by a dynamic imbalance of the immune system between two extremes: “immunoparalysis” and “hyperactivation.” This dysregulation se...

Triple-negative breast cancer (TNBC) is a subtype of breast cancer with strong invasiveness, limited treatment options, and poor prognosis. Its early accurate diagnosis and individualized treatment are major challenges f...

IntroductionClinical simulation has become established as a key tool in healthcare education; however, evidence regarding its multidisciplinary implementation in university hospitals, integrating distinct professional pr...

BackgroundClinician-scientists play a vital role in advancing health and medical research and health system innovation, yet their engagement in research, alongside their clinical role, is rarely measured in a systematic ...

Fuzi, the processed lateral root of Aconitum carmichaelii Debeaux (Ranunculaceae), is a vital yet highly toxic botanical drug in traditional Chinese medicine. However, its narrow therapeutic window, driven by highly toxi...

Di(2-ethylhexyl) phthalate (DEHP) is a commonly used plasticizer that has raised significant concerns due to its strong endocrine-disrupting effects, which are closely associated with developmental toxicity. While previo...

ObjectiveThis review summarizes the current evidence on the impact of isolated antiphospholipid antibody positivity (IAAP) on pregnancy outcomes. It analyzes risk differentials across antibody subtypes, synthesizes the u...

Artificial intelligence (AI) has emerged as a transformative force in modern ophthalmology, enabling rapid advances in disease detection, clinical decision support, workflow optimization, and tele-ophthalmology. Ophthalm...

ObjectiveTo systematically map the evolution, academic network structure, and emergent research fronts of functional magnetic resonance imaging (fMRI) applications in prolonged disorders of consciousness (pDoC) through b...

BackgroundMacrophage polarization plays a critical role in shaping the immunosuppressive tumor microenvironment (TME) of prostate cancer (PCa). Tumor-associated macrophages (TAMs), particularly those exhibiting immunoreg...

Sepsis remains one of the most complex and lethal syndromes in pediatric critical care, driven by dysregulated and heterogeneous host responses to infection. Despite decades of biomarker research, few biomarkers have bee...

IntroductionAssisted reproductive technology (ART) practice varies widely across centers and evolves rapidly, often outpacing the generation of randomized evidence. OPERA (Observational ProjEct for a Research database fo...

ObjectivesThis study aims to delineate the research landscape and evolutionary trajectory of the GLIM criteria in oncology. By mapping development from initial diagnosis to emerging frontiers, it identifies research hots...

BackgroundGranular cell astrocytoma (GCA) is a rare, morphologically distinct variant of IDH-wildtype glioblastoma that can appear deceptively low-grade yet behave aggressively. Its molecular features remain poorly defin...

BackgroundYupingfeng Powder (YPF), a classical Chinese herbal formula composed of Astragalus membranaceus, Atractylodes macrocephala, and Saposhnikovia divaricata, has demonstrated potential efficacy in the treatment of ...

IntroductionDNGR-1 (CLEC9A), a C-type lectin receptor specifically expressed on human BDCA3+ and murine CD8α+/CD103+ conventional type 1 dendritic cells (cDC1), acts as a damage-associated molecular pattern (DAMP) recep...

With the rapid growth of electronic health records, medical imaging, and high-throughput omics data, precision oncology faces increasing demands for cross-modal information integration and complex clinical decision suppo...

BackgroundGlobally, gestational diabetes mellitus (GDM) is a growing health problem. When diagnosed with GDM, women often lack adequate health systems and social support, finding themselves alone at the frontier of epide...

BackgroundGestational diabetes mellitus (GDM) is an increasingly important contributor to maternal and neonatal morbidity in Africa, yet the evidence base remains fragmented across settings and research domains. This stu...