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Acute myeloid leukemia (AML) is the most frequent type of leukaemia in adults, often with poor outcomes due to the complex genetic landscape and low treatment efficacy. Autophagy, a conserved degradation process, plays a...

Adoptive therapy with CD19 chimeric antigen receptor (CAR) T cells is effective against B-cell malignancies; however, T-cell activation rapidly declines, increasing the risk of early leukemia relapses. To augment CD19 CA...

BackgroundCentral nervous system (CNS) relapse in acute lymphoblastic leukemia (ALL) may occur despite systemic remission and can present with isolated neuro-ophthalmologic symptoms. Early diagnosis may be challenging as...

ObjectiveAcute myeloid leukemia (AML) has seen a significant increase in cases recently, often leading to a poor outlook. Dysregulated cell death is a characteristic of AML that aids in both the formation and advancement...

BackgroundCurrent genetic risk stratification systems for acute myeloid leukemia (AML), including the 2017 European Leukemia Network (ELN), 2022 ELN, and 2023 China (CN) stratifications, inconsistently categorize key gen...

IntroductionAcute Lymphoblastic Leukemia (ALL) is a hematological malignancy, which is life-threatening and demands rapid and precise diagnosis to either enhance or worsen the survival chances. Traditional diagnostic met...

IntroductionThe World Health Organization classification of tumors of hematopoietic and lymphoid tissues recognizes acute erythroid leukemia as a distinct entity under myeloid neoplasms. Erythroblastic sarcoma, also know...

Creatine kinase (CK) is an enzyme that plays a pivotal role in various physiological processes, including metabolism and muscle function. This enzyme is found in high concentrations in skeletal muscle and the myocardium,...

Central nervous system (CNS) involvement by CLL is rare. We report a non-treated CLL patient with low-risk factors, but showed leptomeningeal involvement during/after neuroborreliosis and EBV meningitis. An 80-year-old w...

PurposesGene mutations identified through next-generation sequencing (NGS) have been increasingly recognised for their clinical significance in myeloid malignancies. However, data concerning Chinese populations remain li...

STAT3 signaling is fundamental to T cells, where it underlies basic cellular processes like metabolism and apoptosis, as well as specialized processes like effector differentiation and cytokine production. However, mutat...

Severe gingival inflammation, which is uncommon in pediatric patients, often indicates underlying systemic conditions. Leukemia, autoimmune diseases, and allergic symptoms can cause gingivitis owing to systemic inflammat...

BackgroundTreatment of childhood cancer is associated with a substantial risk of life-threatening complications that may require admission to a pediatric intensive care unit (PICU). Data describing clinical characteristi...

In enzootic bovine leukosis (EBL), a B-cell lymphoma caused by bovine leukemia virus (BLV) infection, immune remodeling within tumor-affected lymph nodes is currently poorly understood. Here, we analyzed chemokine produc...

BackgroundNon–Down syndrome acute megakaryoblastic leukemia (non–DS–AMKL) is a rare but high-risk subtype of pediatric AML with dismal outcomes. Allo-HSCT in first complete remission (CR1) is recommended as the pre...