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Understanding why college students consider changing majors is critical for improving academic fit and supporting career development in higher education. Drawing on a mixed-methods design, this study examines how social ...

BackgroundChronic kidney disease (CKD) is a major global health burden with substantial morbidity and mortality. Proteinuria is strongly associated with adverse renal outcomes, and podocyte pyroptosis is increasingly rec...

The menstrual cycle affects many aspects of female physiology, from the immune system to behavioral and emotional regulation. It is unclear however if these physiological changes are reflected in everyday, naturalistic l...

BackgroundParenting stress evokes harsh discipline and induces internalizing problems in children and adolescents. To test this hypothesis, this study examined the potential mediating role of harsh discipline in the asso...

Adolescents encounter large volumes of non-core (i.e., nutritionally poor and unhealthy) food messages on social media. The relationship between these messages and eating is a product of both the volume of exposure to th...

IntroductionCognitive reappraisal is widely regarded as adaptive; however, strategies that impose control to reduce unpleasant emotion may involve tradeoffs when individuals encounter personally meaningful reminders of p...

Circadian rhythms are essential for maintaining intervertebral disc (IDD) homeostasis and regulate cellular metabolism, mechanical responses, and therapeutic efficacy. Core clock genes, especially CLOCK and BMAL1, have c...

N6-methyladenosine (m6A) is a major post-transcriptional RNA modification, and the demethylase ALKBH5 has emerged as a versatile but highly context-dependent regulator of RNA fate. This review integrates current evidence...

While 60 countries have expanded legal abortion access over the past three decades, implementation gaps persist, necessitating innovative approaches beyond conventional law reform. This paper examines the concept of mens...

IntroductionAquatic light environments are increasingly altered by human activity, yet the endocrine and molecular mechanisms enabling fish to cope with extreme photoperiods remain poorly understood. This study investiga...

Drought stress limits wheat productivity at terminal stage by disrupting physiological activities, impairing cellular homeostasis, and decreasing grain yield. Present study elucidated the role of potassium silicate (K2Si...

Galectins, a family of animal lectins, play central roles in immune system regulation, shaping both innate and adaptive responses in physiological and pathological processes. These include rheumatoid arthritis (RA), a ch...

BackgroundItaly’s rehabilitation workforce is fragmented and regulated by outdated decrees, limiting alignment with WHO and EU standards, and hindering efficiency, equity, and international comparability.MethodologyNar...

BackgroundCancer cell evasion of the immune response is critical to cancer development and metastases. Clinicians' ability to kickstart the immune system to target these rogue cells is an ever-growing area of research an...

BackgroundChronic psychological stress, impaired attentional functioning, and reduced psychological resilience represent major public health challenges among adults, contributing to adverse mental and physical health out...

With the intensification of social competition and the diversification of campus life, college students are confronted with increasingly prominent psychological challenges such as academic pressure and interpersonal conf...

BackgroundPancreatic cancer (PC) is characterized by a highly immunosuppressive microenvironment, limiting the efficacy of immunotherapy. T-cell regulation plays a pivotal role in anti-tumor immunity. However, the progno...

Nasopharyngeal carcinoma (NPC) is a metastasis-prone malignancy that is highly prevalent in endemic regions. Epigenetic dysregulation, including aberrant DNA/RNA/protein methylation, histone modifications, and non-coding...

Craniofacial morphogenesis is a highly coordinated developmental process governed by complex genetic and molecular interactions. Among these, the PAX family of transcription factors plays a pivotal role in the regulation...

BackgroundNonsuicidal self-injury (NSSI) is heterogeneous, yet clinically useful exploratory subgrouping remains limited. We examined whether motivational and addiction-like features could delineate meaningful data-drive...

The opening and closing of stomata are controlled by the integration of environmental and endogenous signals. Here, we show the effects of combining elevated atmospheric carbon dioxide concentration (eCO2; 600 μmol mol-...

High-altitude environments impose substantial metabolic constraints on human physiology, with oxygen limitation driving profound alterations in lipid regulation. This narrative review synthesizes current evidence on the ...

IntroductionIn recent years, widespread internet and mobile device use has reshaped adolescents’ reading, study, and information-evaluation practices. In Chile, this occurs in a context of high connectivity but persist...

IntroductionMusic-induced analgesia (MIA) has significant clinical value for patients with fibromyalgia (FM) and serves as a key model for understanding the complex neural mechanisms underlying the effects of music on ph...