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El desarrollo de modelos animales capaces de reproducir enfermedades humanas permite realizar estudios sobre las características, la prevención y el tratamiento de las mismas. Desde 1962, se utiliza el stock de ratones...

Entre las cepas de ratones inmunodeficientes disponibles en Argentina se encuentra la N:NIH (S)-Fox1nu. Se utiliza fundamentalmente como modelo animal para el transplante de tumores humanos. Estos ratones se producen baj...

Access to detailed information on cells loaded with nanoparticles with nanoscale precision is of a long-standing interest in many areas of nanomedicine. In this context, designing a single experiment able to provide stat...

Abstract Non-small cell lung cancer (NSCLC) is a major cause of cancer-related mortality globally, linked to an immunosuppressive microenvironment. Circular RNA circSPARC is crucial in cancer, but its function in NSCLC r...

ABSTRACT For centuries, medicinal plants with abundant supplies of phytochemicals that are physiologically active have been used in traditional medicine. Numerous of these contain anti-inflammatory and antioxidant qualit...

IntroductionHormone-associated cancers use steroid metabolism to grow and avoid the immune system, while traditional treatments have to deal with drug resistance and systemic toxicity.MethodsThis study is mainly divided ...

IntroductionFc-mediated antibody effector functions play key roles in both antiviral immunity and immunopathology in COVID-19. While antibody-dependent cellular phagocytosis (ADCP) and antibody-dependent cellular cytotox...

Abstract Radiotherapy resistance (RT resistance) remains a major obstacle in lung adenocarcinoma (LUAD) treatment, with dysregulated apoptosis being a key contributor. This study aim to investigate the role of PDPK1 in R...

Here, we identify a novel signaling pathway in which Rnd3 regulates the metastatic potential of lung cancer cells. Understanding this pathway could be leveraged to target metastatic disease. Rnd3 regulates cellular proce...

Abstract Background Non-small-cell lung cancer (NSCLC) exhibits pronounced molecular heterogeneity, and current predictive models rarely incorporate mitochondrial quality-control programs such as mitophagy. We hypothesiz...

We report the synthesis and biological evaluation of a ternary copper complex, [Cu(5HTP)(phen)(H2O)](NO3).2H2O, with the antioxidant agent 5-hydroxytryptophan (5-HTP) and phenanthroline (phen, added to improve its lipoph...

Abstract Background Non-small cell lung cancer (NSCLC) is a leading cause of cancer mortality. This study examines whether the deubiquitinase USP4 promotes NSCLC progression by stabilizing PAF1 and opposing the E3 ligase...

c-Jun is a member of the early mammalian transcriptional regulators belonging to the AP-1 family, which participates in a wide range of cellular processes such as proliferation, apoptosis, tumorigenesis, and differentiat...

Three tumor cell lines of lung (A549), colon (HT29) and breast (MDA-MB-231) were used to evaluate the antiproliferative effect of ethanol and dichloromethane extracts and seven fractions obtained by flash column chromato...

En los ítems anteriores se ha establecido claramente la importancia de la vía de síntesis del mevalonato y sus derivados esferoides y no esferoides en el crecimiento y la proliferación celular. Ha quedado claro que l...

Ethanol and dichloromethane extracts from the marine sponge Iotrochota birotulata collected in the Urabá Gulf (Colombia) were tested against three human tumor cellular lines, including lung (A- 549), colon (HT29) and ...

Fil: Scaglia, Natalia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner...

Fourteen compounds were isolated from the rhizome of Trillium tschonoskii Maxim. By spectroscopic analysis, these compounds were established as Gracillin (1), Paris saponins V (2), Paris saponins VI (3), Paris saponins H...