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Con motivo del septuagésimo cumpleaños del Dr. Bernhard König y como resultado del trabajo conjunto de Folke Gernert desde Kiel, alma mater del proyecto, en la dirección del equipo de discípulos de König e investig...

Materias / palabras clave: Literary criticism; Ancient and classical; Crítica literaria; Antigua y clásica

Abstract Background Diabetes is associated with a high incidence of diabetic foot and peripheral artery disease and with markedly increased lifetime amputation risk. Here we investigated predictors of reamputation risk a...

ABSTRACT Background and Aims In Germany, the “morning after pill” (oral emergency contraception [EC]), which contains the active ingredients ulipristal acetate (UPA) and levonorgestrel (LNG), can only be dispensed by...

Abstract Objective New Zealand White (NZW) rabbits are widely used in interventional radiology research due to their suitability for human-sized treatment and imaging equipment, offering high translational potential. Thi...

Abstract Background Delirium is a neuropsychiatric syndrome associated with serious complications. Residents of nursing homes are particularly vulnerable to developing delirium. Nurses play a key role in the prevention, ...

Premise of the study: We developed microsatellite markers to study clonal growth and interspecific hybridization in the Patagonian and subantarctic plant Hypochaeris incana (Asteraceae) and its closest relatives. Methods...

Understanding factors that regulate zygotic genome activation (ZGA) is critical for determining how cells are reprogrammed to become totipotent or pluripotent. There is limited information regarding how this process occu...

Abstract Seismic anisotropy, observed in the lowermost mantle near Large Low‐Shear‐Velocity Provinces (LLSVPs), is likely caused by strong deformation from mantle flow interacting with these regions and/or plume form...

Background & Aims: Atezolizumab/bevacizumab (A/B) and durvalumab ± tremelimumab (DT/D) are preferred first-line regimens for the treatment of hepatocellular carcinoma (HCC). Although both therapies share an anti-PD-...

Abstract Background The team-based, interdisciplinary rehabilitation model, PREVention of Sickness Absence for Musculoskeletal disorders (PREVSAM), was developed and evaluated in a Swedish primary care context. The purpo...

Abstract INSPIRE-PNRM+ (short for InterdiSciPlinary and InteRsectoral telemedIcal Evaluation, Coordination and Therapy at the ParkinsonNet RheinMain+) is an one-year, multicentre, interventional, open-label, two-arm, 1:1...

Pancreatic ductal adenocarcinoma (PDAC) exhibits pronounced desmoplasia, primarily attributed to the activation of pancreatic stellate cells (PSCs) from a quiescent state (quiescent PSCs [qPSCs]) to an activated form (ac...

Abstract One of the biggest challenges in tissue engineering and regenerative medicine is to ensure oxygen supply of cells in the (temporary) absence of vasculature. With the vision to exploit photosynthetic oxygen produ...

Longitudinal profiling of 136 newborns shows thymic output peaks at 3–4 mo, correlating with plasma RANKL, lymphotoxin-α, and the TCRD variant rs2204985. In thymic tissue, RANKL tracks medullary—but not cortical—e...

People with dementia (PwD) face cognitive decline, placing added stress on family caregivers. Challenging behaviour, such as agitation, is one of the prominent behaviours exhibited by PwD, and family caregivers are often...

A training algorithm that maximizes the margin between the training patterns and the decision boundary is presented. The technique is applicable to a wide variety of the classification functions, including Perceptrons, p...

Materias / palabras clave: Support vector machine; Computer science; Regularization (linguistics); Quadratic programming; Perspective (graphical); Machine learning; Relevance vector machine; Function (biology); Regular polygon; Artificial intellig...

The ability of learning networks to generalize can be greatly enhanced by providing constraints from the task domain. This paper demonstrates how such constraints can be integrated into a backpropagation network through ...

BACKGROUND: Goal-directed therapy has been used for severe sepsis and septic shock in the intensive care unit. This approach involves adjustments of cardiac preload, afterload, and contractility to balance oxygen deliver...

Coot is a molecular-graphics application for model building and validation of biological macromolecules. The program displays electron-density maps and atomic models and allows model manipulations such as idealization, r...