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42 resultados encontrados.

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Bangle (Zingiber purpureum Rosc.) extract alleviates skeletal muscle atrophy through modulating Akt/FoxO1/NFκB pathway and enhancing mitochondrial biogenesis in a mouse colitis model
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Bangle (Zingiber purpureum Rosc.) extract alleviates skeletal muscle atrophy through modulating Akt/FoxO1/NFκB pathway and enhancing mitochondrial biogenesis in a mouse colitis model
Shiho Kasai et al · Elsevier · 2026 · ISSN 1756-4646
Bangle belongs to the ginger family and has anti-inflammatory properties; however, its efficacy against skeletal muscle atrophy in ulcerative colitis (UC) remains unexplored. This study investigated the effects of Bangle...
LCC LCC:Nutrition. Foods and food supplyIdioma eng
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Epigenetic analysis of sheep mycoplasma pneumonia and the effect of FOXF1 on Mycoplasma ovipneumoniae infection
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Epigenetic analysis of sheep mycoplasma pneumonia and the effect of FOXF1 on Mycoplasma ovipneumoniae infection
Kai Huang et al · Taylor & Francis Group · 2026 · ISSN 2150-5594
Mycoplasma pneumonia (MP), as a global infectious disease in sheep, seriously affects the production performance of sheep and economic benefits of sheep industry. However, current research on sheep resistance to MP remai...
LCC TENDOkluZmVjdGlvdXMgYW5kIHBhcmFzaXRpYyBkaXNlYXNlcw~~Idioma eng
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Long noncoding RNA FOXP1-DT modulates regulatory T cells in Graves’ disease
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Long noncoding RNA FOXP1-DT modulates regulatory T cells in Graves’ disease
Qian Xu et al · Nature Portfolio · 2026 · ISSN 2045-2322
Abstract Regulatory T cells (Tregs) are key contributors to maintaining immune system stability, and their impairment has been linked to the pathogenesis of Graves’ disease (GD). However, the precise molecular mechanis...
LCC LCC:Medicine; TENDOlNjaWVuY2U~Idioma eng
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SIRT1 induces FOXO1/autophagy/NCOA4-induced ferroptosis and accelerates the progression of cerebral infarction by inhibiting the E2F1/NOTCH-1/YAP signaling pathway
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SIRT1 induces FOXO1/autophagy/NCOA4-induced ferroptosis and accelerates the progression of cerebral infarction by inhibiting the E2F1/NOTCH-1/YAP signaling pathway
Gang Wang et al · Nature Portfolio · 2026 · ISSN 2045-2322
Abstract To access the effect of SIRT1 in cerebral infarction and to explore its mechanism of ferroptosis. Bioinformatic Analysis was used to discover the associations between Ferroptosis-Related Genes and Cerebral Infar...
LCC LCC:Medicine; TENDOlNjaWVuY2U~Idioma eng
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STUB1 downregulates TOP2A through a dual mechanism of ubiquitination and FOXM1-mediated transcription repression, suppressing breast cancer growth and enhancing sensitivity to chemotherapy
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STUB1 downregulates TOP2A through a dual mechanism of ubiquitination and FOXM1-mediated transcription repression, suppressing breast cancer growth and enhancing sensitivity to chemotherapy
Baohui Yue et al · BMC · 2026 · ISSN 1689-1392
Abstract Background DNA topoisomerase IIɑ (TOP2A) is crucial for maintaining genomic stability and is an important target for genotoxic chemotherapeutic drugs. STIP1 homology and U-box-containing protein 1 (STUB1) is a ...
LCC LCC:CytologyIdioma eng
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Sugen kinase 495 promotes the proliferation, migration and invasion of lung squamous cell carcinoma cells by targeting Foxo1 transcription factor
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Sugen kinase 495 promotes the proliferation, migration and invasion of lung squamous cell carcinoma cells by targeting Foxo1 transcription factor
Yuanmei Lou et al · BMC · 2026 · ISSN 1475-2867
Abstract Sugen kinase 495 (Sgk495), also known as Serine/Threonine Kinase 40 (STK40), is a pseudokinase previously implicated in T cell differentiation via regulation of Foxo transcription factors. However, its function ...
LCC TENDOk5lb3BsYXNtcy4gVHVtb3JzLiBPbmNvbG9neS4gSW5jbHVkaW5nIGNhbmNlciBhbmQgY2FyY2lub2dlbnM~; LCC:CytologyIdioma eng
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Defining Genotype to Phenotype Causality in Patients with Diverse FOXN1 Variants
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Defining Genotype to Phenotype Causality in Patients with Diverse FOXN1 Variants
Katelyn Boetel et al · Rockefeller University Press · 2026 · ISSN 3065-8993
BackgroundForkhead box N1 (FOXN1) is the master transcriptional regulator of thymic epithelial cells (TECs), quintessential for T cell development. Well-defined biallelic FOXN1 loss-of-function variants lead to congenita...
LCC LCC:Immunologic diseases. AllergyIdioma eng
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Dominant-Negative FOXN1 Mutations: Clinical Variability and Omenn Syndrome Management in an International Cohort of 7 Families
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Dominant-Negative FOXN1 Mutations: Clinical Variability and Omenn Syndrome Management in an International Cohort of 7 Families
Paola Suhet et al · Rockefeller University Press · 2026 · ISSN 3065-8993
BackgroundTranscription factor forkhead box protein N1 (FOXN1) is the master transcription factor required for differentiation and maintenance of thymic epithelial cells (TECs) and is not only required for embryonic thym...
LCC LCC:Immunologic diseases. AllergyIdioma eng
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First record of Indian Fox in Dang, Gujarat, India
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First record of Indian Fox in Dang, Gujarat, India
Mohmad Navaz Dahya et al · Wildlife Information Liaison Development Society · 2026 · ISSN 0974-7893
This study documents the presence of the Indian Fox Vulpes bengalensis in the Dang District of Gujarat, an area where its occurrence had not been previously reported. Using camera-trapping techniques, we provide new insi...
LCC TENDOkVjb2xvZ3k~; LCC:General. Including nature conservation, geographical distributionIdioma eng
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Human FOXP3 Isoforms in Health and Disease
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Human FOXP3 Isoforms in Health and Disease
Merve Nida Gokbak et al · Rockefeller University Press · 2026 · ISSN 3065-8993
Forkhead box P3 (FOXP3) is the master transcription factor of regulatory T cells (Tregs) and is essential for maintaining immune tolerance. FOXP3 is stably expressed in Tregs, driving their suppressive function, and it i...
LCC LCC:Immunologic diseases. AllergyIdioma eng
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Leishmania infantum in red foxes (Vulpes vulpes): from clinical findings to cytokine expression
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Leishmania infantum in red foxes (Vulpes vulpes): from clinical findings to cytokine expression
Mario H. Alves et al · BMC · 2026 · ISSN 1756-3305
Abstract Background The life cycle of Leishmania infantum is maintained mainly in dogs in anthropogenic environments and in many other wild animals in the sylvatic cycle. The ecological plasticity of some wild canids fac...
LCC TENDOkluZmVjdGlvdXMgYW5kIHBhcmFzaXRpYyBkaXNlYXNlcw~~Idioma eng
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Novel FOXN1 Variant as Cause of Neonatal T Cell Lymphopenia
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Novel FOXN1 Variant as Cause of Neonatal T Cell Lymphopenia
Sonia Joshi et al · Rockefeller University Press · 2026 · ISSN 3065-8993
In the last decade, diagnostic detection of severe combined immune deficiency (SCID) has improved with the widespread implementation of universal newborn screening (NBS) for SCID in the United States. Our case identifies...
LCC LCC:Immunologic diseases. AllergyIdioma eng
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Peripheral Expression of FOXP3 in Brazilian Patients with IPEX Syndrome: From FOXP3 Biomarker to Targeted FOXP3 Therapy Within the CNE3I
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Peripheral Expression of FOXP3 in Brazilian Patients with IPEX Syndrome: From FOXP3 Biomarker to Targeted FOXP3 Therapy Within the CNE3I
Leonardo Oliveira Mendonça et al · Rockefeller University Press · 2026 · ISSN 3065-8993
Immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome is a monogenic disorder caused by loss-of-function mutations in the FOXP3 gene, which is critical for the development of functional regulato...
LCC LCC:Immunologic diseases. AllergyIdioma eng
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USP18 mediates high glucose‐induced cardiomyocyte injury by regulating the JAK/STAT signaling pathway through stabilizing FOXC2 expression
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USP18 mediates high glucose‐induced cardiomyocyte injury by regulating the JAK/STAT signaling pathway through stabilizing FOXC2 expression
Zhengrong Xu et al · Wiley · 2026 · ISSN 2040-1116
ABSTRACT Background Cardiomyopathy is one of the complications of diabetes, among which myocardial fibrosis is the most typical feature. Ubiquitin‐specific peptidase 18 (USP18) is a deubiquitinating enzyme. Multiple st...
LCC LCC:Diseases of the endocrine glands. Clinical endocrinologyIdioma eng
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The FOXE1 rs965513 polymorphism: a pleiotropic risk locus associated with thyroid function, BRAF V600E mutation, and susceptibility to papillary thyroid cancer
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The FOXE1 rs965513 polymorphism: a pleiotropic risk locus associated with thyroid function, BRAF V600E mutation, and susceptibility to papillary thyroid cancer
Wenran Zhang et al · Nature Portfolio · 2026 · ISSN 2045-2322
Abstract Although papillary thyroid cancer (PTC) genetic research has advanced from identifying driver genes to investigating susceptibility loci and gene-environment interactions, data in Chinese populations remain limi...
LCC LCC:Medicine; TENDOlNjaWVuY2U~Idioma eng
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CD8 regulatory T cells are a novel type regulatory T cells in the induction of transplantation immune tolerance
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CD8 regulatory T cells are a novel type regulatory T cells in the induction of transplantation immune tolerance
Jin-can Huang et al · Frontiers Media S.A · 2026 · ISSN 1664-3224
ObjectiveRegulatory T cells (Tregs) play an essential role in transplantation immune tolerance. Although CD4+ Tregs have been extensively studied, the contribution of CD8+ regulatory T-cell subsets to transplant toleranc...
LCC LCC:Immunologic diseases. AllergyIdioma eng
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Genome sequence of the ornamental plant Digitalis purpurea reveals the molecular basis of flower color and morphology variation
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Genome sequence of the ornamental plant Digitalis purpurea reveals the molecular basis of flower color and morphology variation
Jakob Maximilian Horz et al · BMC · 2026 · ISSN 1471-2164
Abstract Digitalis purpurea (foxglove) is a widely distributed ornamental plant. Here, we present a long read sequencing-based genome sequence of a magenta flowering D. purpurea plant and a corresponding prediction of ge...
LCC TENDOkJpb3RlY2hub2xvZ3k~; LCC:GeneticsIdioma eng
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Assessment of environmental contamination with Echinococcus spp. through DNA detection in free-roaming canid feces and soil in human echinococcosis hotspots from the Three-River-Source Region of the Qinghai-Tibet Plateau, China
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Assessment of environmental contamination with Echinococcus spp. through DNA detection in free-roaming canid feces and soil in human echinococcosis hotspots from the Three-River-Source Region of the Qinghai-Tibet Plateau, China
Xueyong Zhang et al · BMC · 2026 · ISSN 1756-3305
Abstract Background The Three-River-Source Region of the Qinghai-Tibet Plateau is a hyperendemic focus for echinococcosis, with Echinococcus granulosus, E. multilocularis, and E. shiquicus circulating between definitive ...
LCC TENDOkluZmVjdGlvdXMgYW5kIHBhcmFzaXRpYyBkaXNlYXNlcw~~Idioma eng
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Buffering effects of shelter and palatable foods mitigate fear responses in foraging wild mice
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Buffering effects of shelter and palatable foods mitigate fear responses in foraging wild mice
Rafal Stryjek et al · Nature Portfolio · 2026 · ISSN 2045-2322
Abstract Animal responses to fear cues are shaped by competing motivations such as hunger, access to mates and safety. In our previous work, wild mice (Apodemus spp.) showed little reaction to non-native predator scents....
LCC LCC:Medicine; TENDOlNjaWVuY2U~Idioma eng
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Capecitabine combined with fecal microbiota transplantation prevents colorectal cancer progression through correction of microbial dysbiosis and immune regulation
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Capecitabine combined with fecal microbiota transplantation prevents colorectal cancer progression through correction of microbial dysbiosis and immune regulation
Muhammad Arshad et al · Nature Portfolio · 2026 · ISSN 2045-2322
Abstract The significant economic burden of colorectal cancer (CRC) necessitates the development of innovative therapeutic approaches. Interest in the gut microbiota’s role in CRC has increased. Capecitabine, as a chem...
LCC LCC:Medicine; TENDOlNjaWVuY2U~Idioma eng
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Determinants of Fate Progression Beyond the Human Tfh Cell Stage
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Determinants of Fate Progression Beyond the Human Tfh Cell Stage
Suzanna Rachimi et al · Rockefeller University Press · 2026 · ISSN 3065-8993
T follicular helper (Tfh) cells have been reported to have multiple trajectories, including terminally differentiated Tfh, memory-like circulatory Tfh (cTfh), and, most recently, induced T follicular regulatory (iTfr) ce...
LCC LCC:Immunologic diseases. AllergyIdioma eng
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Efficiency of bone marrow-derived cells in the treatment of experimental autoimmune type 1 diabetes: immunomodulatory and anti-apoptotic properties
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Efficiency of bone marrow-derived cells in the treatment of experimental autoimmune type 1 diabetes: immunomodulatory and anti-apoptotic properties
Mohamed Nassef et al · BMC · 2026 · ISSN 1471-2172
Abstract Background Bone marrow-derived cell (BMDC) transplantation is increasingly recognized as a valuable strategy in regenerative therapies. However, the data regarding the impact of BMDC transplantation on the sever...
LCC LCC:Immunologic diseases. AllergyIdioma eng
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Genetic alterations in poor-quality individually selected sperm highlight candidate biomarkers for male subfertility
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Genetic alterations in poor-quality individually selected sperm highlight candidate biomarkers for male subfertility
Mohammad A. Al Smadi et al · Nature Portfolio · 2026 · ISSN 2045-2322
Abstract Whole-genome sequencing (WGS) of morphology-selected sperm pools provides an exploratory approach for investigating genomic features associated with variable sperm quality. In this study, pooled DNA from 1500 in...
LCC LCC:Medicine; TENDOlNjaWVuY2U~Idioma eng
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Increased susceptibility to 4-HNE-induced toxicity and impaired development in a model of ALDH4A1-deficient pediatric epilepsy carrying the S352L variant
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Increased susceptibility to 4-HNE-induced toxicity and impaired development in a model of ALDH4A1-deficient pediatric epilepsy carrying the S352L variant
Benjamin R. Kraemer et al · Nature Portfolio · 2026 · ISSN 2399-3642
Abstract Certain human mutations in the mitochondrial aldehyde dehydrogenase 4A1 (ALDH4A1) lead to a severe, paediatric form of epilepsy and developmental abnormalities, yet the precise molecular mechanism leading to the...
LCC LCC:Biology (General)Idioma eng
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