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Copper is an essential trace element in the human body, extensively involved in key physiological and biochemical processes such as antioxidant defense, energy metabolism, neural signaling, and immune regulation. In rece...

Tianqing Zhang,1 Sijie Xiao,2 Yanfu Xia,3 Kun Chen,1 Honglan Liu,1 Ping Zhang,1 Li Luo1 1Department of Cardiology, Changde Hospital, Xiangya School of Medicine, Central South University (The First People’s Hospital of ...

Seed germination is severely constrained by soil salinity, limiting crop establishment in salt-affected agricultural lands. This study investigated whether seed priming with molybdenum nanoparticles (Mo NPs) enhances ger...

Abstract Background Variants in OTUD5 are associated with neurodevelopmental disorders (NDDs), yet the underlying molecular mechanisms remain unclear. This study aimed to investigate the pathogenicity of a novel OTUD5 va...

Abstract Oocyte development requires tight regulation of transcription and RNA metabolism, which is coordinated by RNA-binding proteins, whose roles in mammalian oogenesis remain incompletely understood. Here, we identif...

Oxidative stress–induced cellular injury is a key mechanism underlying tissue dysfunction, and food-derived phenolic compounds have attracted interest as natural modulators of redox homeostasis. Sensory cells, includin...

Osteoporosis (OP), a widespread metabolic bone condition characterized by diminished bone mass and compromised microarchitecture, poses a significant global health challenge. The gut microbiota (GM) regulates bone homeos...

Abstract Background Lung squamous cell carcinoma (LUSC) is one of the common pathological subtypes of non-small cell lung cancer, which poses significant treatment challenges due to poor response to conventional therapie...

Osteoporosis is a very common disease nowadays, and it is mostly seen in postmenopausal women. In postmenopausal women, with the decrease of estrogen, directly or indirectly, it makes the decrease of bone mineral density...

The targeted-modified low-molecular-weight pectin (LMP), a natural polysaccharide derived from citrus fruits, represents a promising food-derived immunomodulatory agent. This study assessed the efficacy of targeted-modif...

Abstract Proper regulation of ribosome biogenesis is essential for stem cell function and tissue homeostasis, yet its upstream control in adult intestinal stem cells (ISCs) remains unclear. Here, we identify the WD repea...

In aquaculture nutrition, alternative protein sources, such as those derived from bacteria, have recently garnered significant attention as safe and viable replacements for traditional protein sources, including fish mea...

Huangjing (Polygonati Rhizoma) is an important medicinal and edible herb, which can be taken orally, brewed in tea, steeped in wine, or used in food processing.The fibrous roots of Polygonum cyrtonema, usually discarded ...

Background: Osteoporosis has long been considered a disorder confined to bone tissue. Growing evidence now highlights its systemic origins, governed by intricate communication between multiple organs. The multi-organ-bon...

Abstract Background High-oleic diets (HODs), have been proposed to improve lipid and glucose metabolism, yet clinical evidence remains inconsistent. This systematic review and meta-analysis aimed to quantitatively evalua...

IntroductionMicrogravity is one type of external stimulus that affects bone homeostasis and bone development. This study investigates the molecular drivers of these effects in order to more fully understand the cellular ...

Abstract Chenopodioideae plants are dominant components of desert ecosystems in arid regions of China and Central Asia and play key roles in maintaining ecosystem stability, while also providing valuable systems for unde...

Epilepsy is a debilitating neurological disorder characterized by recurrent seizures, affecting millions of patients worldwide. Retrospective studies in temporal lobe epilepsy (TLE) patients have shown a high incidence o...

Abstract Fibrous dysplasia (FD) is a rare disorder associated with fractures and deformities. FD lesions produce excess phosphaturic hormone fibroblast growth factor 23 (FGF23), leading to hyperphosphaturia in most patie...

Abstract Background Circadian rhythms are endogenous, transcription-translation feedback loops that align cellular activities with the 24-h light–dark cycle. Stem-cell populations across tissues exhibit circadian oscil...

Abstract Background Aging alters the systemic steroid environment, including reductions in circulating androgens. In peripheral tissues, androgen exposure is regulated mainly by local steroid metabolism, which can activa...

Background and aimsLiver sinusoidal endothelial cells (LSECs) have a key role in maintaining organismal homeostasis by scavenging blood-borne molecules and inducing specific immune tolerance to ingested antigens. The sca...