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Fractionation of the ethyl acetate soluble fraction from the ethanol extract of the leaves of Scutia buxifolia (Rhamnaceae) led to the isolation of quercetin, quercetin 3-0-rhamnoside (quercitrin), quercetin 3-0-glucosid...

A reproducible and selective method for the simultaneous determination of cyclophosphamide (CP) and ifosfamide (IF) in plasma has been developed and validated using isocratic elution. The assay is performed by HPLC-UV, w...

A simple, rapid, sensitive and selective method of high-performance liquid chromatography with fluorescence detection was developed for determination of puerarin in rat plasma. Chromatography was carried out on a reverse...

A new HPLC-DAD method has been developed and validated for the simultaneous analysis of five flavonoids (rutin, quercitrin, quercetin, kaempferol, and isorahamnetin) in rat plasma. Sample pretreatment consisted of a liqu...

Se desarrolló y validó un método rápido y simple por HPLC para la determinación de carbamacepina en plasma humano. Las condiciones cromatográficas fueron: columna C-18, fase móvil acetonitrilo:metanol:acetato de a...

Benzocaine (BZC) is an ester-type local anesthetic used mainly in topical, dermal and mucosal formulations. The present work consists of the development and validation of analytical methodology for evaluation of benzocai...

As ormosílicas (sílicas organicamente modificadas) são materiais de impressão molecular (MIS) que têm surgido como sorventes mais seletivos para a extração em fase sólida (SPE). Nesta pesquisa foi avaliado o de...

The aim of this work was to develope a dissolution test for nimesulide immediate release tablets in a medium that assure sink conditions. A solubility study was elaborate to assist in the selection of a dissolution mediu...

O ácido micofenólico (AMF) é um fármaco imunosupressor amplamente utilizado em transplantes renais. O monitoramento terapêutico de AMF é recomendado para melhorar os resultados clínicos e reduzir os efeitos advers...

Therapeutic importance and benefices caused by antineoplastic drugs are unquestionable however unfortunately well-known are their side effects. So, the extensive use and the exposure to multiple agents may be at risk to ...

A stability-indicating high-performance liquid chromatographic (HPLC) and a second-order derivative spectrophotometric (UVDS) analytical methods were validated and compared for determination of simvastatin in tablets. Th...