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Background: Acute kidney injury (AKI) is prevalent among hospitalized patients and is frequently complicated by hyperkalemia (HyperK), kidney replacement therapy (KRT), and major adverse kidney events (MAKE). Early predi...

Abstract Economic inequality is a critical issue in elections and legislating, so having an informed electorate is vital to sensible policymaking. Unfortunately, misperceptions about the true extent of inequality abound....

Purpose: To assess the impact of non-surgical periodontal treatment (NSPT) on the oxidative and endoplasmic reticulum (ER) stress response of leukocytes, and to examine whether obesity modulates the biological response t...

Joint replacement surgery transforms lives for patients with higher body mass index (BMI). Strong evidence shows safe outcomes and meaningful benefit, yet access remains restricted by BMI alone, an approach that risks st...

Jonathan Minh Phuong,1 James Higgerson,1 Emma LT Pearce,1 Sarah C Willis,2 Ellen Ingrid Schafheutle1 1Centre for Pharmacy Workforce Studies, School of Health Sciences, Faculty of Biology Medicine and Health, The Universi...

Abstract Generative deep learning models have demonstrated significant potential in designing drug-like molecules. However, medicinal chemistry typically requires generating analogues that combine structural similarity w...

Abstract Bronchopulmonary dysplasia (BPD) is a common complication among preterm neonates, with portable X-ray imaging serving as the standard diagnostic modality in neonatal intensive care units (NICUs). However, lung m...

Abstract The primary goal of fluid therapy is to optimize cardiac output in preload-dependent patients. However, all types of fluid solutions can have side effects. Oral water intake regulates fluid absorption, leading t...

El acceso al agua potable de calidad es fundamental para la salud pública. Este estudio evalúa la calidad del agua en Bacerac, Sonora, considerando su variabilidad estacional y cumplimiento con la NOM-127-SSA1-2021. Se...

Abstract Background Gait impairments following chronic neurological conditions, such as spinal cord injury (SCI), represent a major challenge for rehabilitation, with limited options to sustain functional recovery and pa...

Abstract Myostatin negatively regulates skeletal muscle size in multiple species, and therefore, myostatin blockade has been therapeutically explored to promote muscle growth in humans, including to counter the muscle lo...

Abstract Background Breast cancer prognosis is the result of complex interactions between tumor biology, treatment, and host factors. While germline genetic variation is increasingly incorporated into breast cancer risk ...

Abstract Background AP01, a novel formulation of inhaled pirfenidone, has demonstrated potential for improved efficacy and safety for idiopathic pulmonary fibrosis (IPF) vs. oral pirfenidone. A 72-week phase 1b study, AT...

Abstract The ongoing outbreak of highly pathogenic avian influenza virus (HPAIV) subtype H5N1 in the U.S. poses a significant public health threat. To date, 70 human cases have been confirmed in the United States, includ...

Abstract Background Telomere length (TL), a biomarker of biological aging, but its association with Alzheimer’s disease (AD) remains unclear. Methods We estimated TL in whole-genome sequencing data from 35,014 Alzheime...

BackgroundMast cells are abundant throughout the lung, positioned near the airway epithelium, vasculature, and interstitium where they function as frontline sentinels to inhaled environmental and chemical stimuli. Throug...

Abstract An early event after lung injury is extracellular matrix (ECM) remodeling and the formation of a provisional matrix. While megakaryocytes and platelets (Mgk/plt) play important roles in hemostasis, their impact ...

El agua subterránea es utilizada por casi dos mil millones de personas en el mundo. La contaminación por microplásticos (MP) está presente en todos los ambientes, pero los estudios sobre MP en aguas subterráneas son...

Abstract Background Limited research exists on the obstetric risk profiles of women in same-sex relationships (WSSR) undergoing childbirth. Methods Population-based cohort study including deliveries in the Swedish Stockh...

Abstract Cavities provide a means to manipulate the optical and electronic responses of quantum materials by selectively enhancing light-matter interaction at specific frequencies and momenta. While cavities typically in...

Introduction Early open fracture management aims to minimise the risk of complications. For the most severe open fracture wounds, multiple irrigation and debridement surgeries are required to overcome severe wound contam...

Abstract Background Therapeutic Communities (TCs) are long-term residential treatment settings for individuals with substance use disorders, who often present with neuropsychological impairments. These impairments may in...

Abstract Cis-acting regulatory enhancer elements are powerful tools for achieving cell type-specific genetic access in adeno-associated virus (AAV) delivery platforms. However, a significant bottleneck in enhancer discov...