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Abstract Background Thiamine (vitamin B1), a cofactor in energy metabolism and antioxidant pathways, may mitigate mitochondrial dysfunction in critical illnesses. However, its association with outcomes in acute respirato...

Abstract Background Prone positioning is recommended for patients with acute respiratory distress syndrome not only to improve oxygenation, but also to reduce lung stress, and lower mortality. The association between imp...

ObjectivesTo characterize swallowing impairment and aspiration risk in patients recovering from acute respiratory events and to identify clinical, functional, and anatomical predictors of airway invasion with a specific ...

BackgroundAcute respiratory distress syndrome (ARDS) secondary to severe acute pancreatitis (SAP) is associated with high mortality; however, dependable biomarkers for early risk assessment remain scarce. The lactate-to-...

Respiratory syncytial virus (RSV) and severe acute respiratory syndrome coronavirus 2 (SARS−CoV−2) represent two extremes in the outcome of antibody−based interventions. The long−acting monoclonal antibody nirsev...

Background and Literature ReviewHypereosinophilic syndrome (HES) is a rare, heterogeneous group of disorders defined by persistent hypereosinophilia (>1,500 cells/µL) with eosinophil-mediated end-organ damage. Its estim...

BackgroundPatients with acute myeloid leukemia (AML) and prolonged neutropenia are at high risk for invasive fungal infections such as fusariosis, which represents the second most common pathogenic mold infection in this...

Abstract Background Retrospective studies frequently use single-time-point Berlin physiologic criteria (PaO2/FiO2 

Hoyeraal-Hreidarsson syndrome (HHS) represents the most severe form of dyskeratosis congenita (DC), a telomere biology disorder caused by pathogenic variants in genes involved in telomere maintenance. DKC1 encodes dysker...

Next-generation metagenomic sequencing (mNGS) enables the direct and unbiased detection of pathogens from clinical samples, overcoming the limitations of standard methods. It is particularly valuable in immunocompromised...

We performed a single-center retrospective analysis of chronic granulomatous disease (CGD) autopsy reports to better understand causes of death, end-organ damage, and disease pathophysiology. Forty-four autopsies of CGD ...

BackgroundTreatment of childhood cancer is associated with a substantial risk of life-threatening complications that may require admission to a pediatric intensive care unit (PICU). Data describing clinical characteristi...

Background Histologic features of pulmonary veno‐occlusive disease (PVOD) and pulmonary capillary hemangiomatosis (PCH) have been described in dogs but without a thorough clinical description. Objectives To report the ...

SARS-CoV-2 is extremely contagious, and most people in the general community are at risk of infection. The coronavirus disease (COVID -19) is caused by SARS-CoV-2 (Severe acute respiratory syndrome coronavirus 2). After ...

Abstract Background Treating severe forms of the acute respiratory distress syndrome and cardiac failure, extracorporeal membrane oxygenation (ECMO) has become an established therapeutic option. Neonatal or pediatric pat...

During influenza epidemics, the increase of the number of acute illness leads to applications to outpatient and emergency services, and it also results in increase of hospitalization for treatment of complications of low...

ABSTRACT A 20‐day‐old, 0.26 kg intact female domestic shorthair kitten was presented for evaluation of labored breathing and decreased appetite. Physical examination and thoracic radiographs were consistent with br...

IntroductionThe ERCC2 gene, located on chromosome 19, is essential for transcription and DNA repair via its protein product, XPD. Mutations in ERCC2 cause disorders such as trichothiodystrophy-1, xeroderma pigmentosum, C...

IntroductionChronic granulomatous disease (CGD) is an inborn error of immunity (IEI) secondary to defects in the phagocyte oxidative burst. Patients mainly experience infections; however, many may also manifest inflammat...

Introduction Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) may cause stress-induced transient acute cardiac dysfunction through myocardial stunning, in the form of exacerbation-triggered Takotsubo ...

Background Acute exacerbations (AEs) drive disease progression and healthcare burden in chronic obstructive pulmonary disease (COPD). Although prior AE history is the strongest predictor of future events, it cannot guide...

This study evaluates whether reductions in airway pressure-time product (ΔPTPaw) during diaphragm neurostimulation-assisted ventilation can reliably quantify respiratory muscle effort. Using data from the STIMULUS trial...

La ventilación mecánica no invasiva y la terapia con cánula de alto flujo son dos terapias que permiten dar apoyo al paciente en situaciones de falla respiratoria aguda, se hace una revisión sobre las diferentes indi...