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Objective: To determine the optimal dosing ratio of the herbal components within compound Hemerocallis citrina Baroni (H. citrina) extract concentrate (CHEC), evaluate its antidepressant effects in zebrafish and mouse mo...

INTRODUCTION: Malva moschata L. has long been used in traditional medicine for its calming and sedative properties, indicating potential antidepressant activity. This study evaluated the antidepressant-like effects of it...

Depression represents a significant global public health problem, negatively affecting patients’ quality of life and social functioning. Despite the increasing availability of effective pharmacological and psychotherap...

ABSTRACT Deep brain stimulation (DBS) for treatment‐resistant depression (TRD) is challenged by significant individual variability in efficacy and unclear neural circuit mechanisms. To address this, a cross‐species, ...

Abstract Background Repetitive transcranial magnetic stimulation (rTMS) is an efficacious therapy for treatment-resistant depression (TRD) and is thought to drive neuroplastic changes in affective networks. However, up t...

Lucie Bartova,1 Mara Lisa Beuster,2 Bruno Bonetti,3 Giuseppe Maina,4,5 Pedro Morgado,6 Johan Nyberg7 1Department of Psychiatry and Psychotherapy, Clinical Division of General Psychiatry, and Comprehensive Center for Clin...

Abstract Aim Whether socioeconomic factors are associated with colorectal cancer (CRC) risk remains unknown, with inconsistent results from different countries. The hypothesis was that both socioeconomic factors and the ...

Dietary lignans (Diet-LIG) are a class of estrogenic plant polyphenols whose improve potential for perimenopausal depression (PMD), a condition driven by estrogen deficiency, remains unexplored. This study aims to invest...

BackgroundTreatment-resistant depression (TRD) is often accompanied by persistent suicidal ideation and poor response to conventional antidepressants. Intranasal esketamine, a non-selective NMDA receptor antagonist, prov...