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BackgroundRare epidermal growth factor receptor (EGFR) mutations have a low incidence, and their response to EGFR tyrosine kinase inhibitors (TKI) has not been sufficiently studied. L747P is a rare EGFR mutation located ...

Breast cancer bone metastasis causes severe complications, yet current radiotherapy has limitations in treating secondary metastases and protecting healthy tissues. This study introduces calcium gadolinium layered double...

Abstract Ewing sarcoma (EWS), a rare pediatric bone tumor, poses unique therapeutic challenges due to its distinct microenvironment and limited molecular understanding. To gain a comprehensive molecular and functional vi...

Abstract Background Most endometrial cancers (75%) are diagnosed in early stages (stages I and II), in which abnormal uterine bleeding is the most frequent clinical sign.When the diagnosis is performed in stage IV, the...

Gastric metastases are rare, accounting for only 0.2%–0.7% of gastric malignancies. Gastric metastasis from primary popliteal fossa leiomyosarcoma (LMS) has not been previously reported. We report a 60-year-old female ...

Introduction Bone metastasis in breast cancer patients can lead to poor quality of life and cause significant morbidity. First-line treatments for bone metastases include bone modifying agents that inhibit osteoclast act...

Abstract Background Although [¹⁸F]PSMA-1007 enables sensitive detection in prostate cancer, heterogeneity in PSMA expression and variable physiologic uptake can limit performance, whereas [¹⁸F]FAPI-42, targeting fi...

IntroductionTherapies for metastatic renal cell carcinoma (mRCC) have evolved significantly, making treatment decisions more complex. We used machine learning (ML) to identify subgroups of patients who have a high probab...

Oral cancer is a malignant neoplasia on the lip and oral cavity. It is generally late-detected, locally invasive, and it has a high propensity for cervical lymph node metastases as well as blood-borne distant metastases....

BackgroundOsteosarcoma (OS) is the most common primary malignant bone tumour in adolescents, and pulmonary metastasis remains the leading cause of death. In skeletally immature patients, the avascular physis is considere...

Materias / palabras clave: bone metastases, bone cancer, skeletal complications, metastatic cancer, orthopedic oncology, myeloma; Medicine: Internal medicine: Specialties of internal medicine: Diseases of the musculoskeletal system; Medicine: Inte...