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Tumor diseases pose an enormous health threat when they become malignant, as in the process of metastasis. Cancer metastasis has been extensively studied in the past, but attention has been focused primarily on the estab...

Abstract Left-sided colorectal cancer (LCRC) and right-sided colorectal cancer (RCRC) show marked differences in prognosis and therapeutic response, yet the underlying molecular mechanisms remain poorly understood. We hy...

Abstract Background Radiomics analysis of 18F-FDG PET/CT enables extraction of high-dimensional quantitative features that may serve as imaging biomarkers for tumor biology. In particular, in non-small cell lung cancer (...

Small cell lung cancer (SCLC) remains one of the most aggressive malignancies, characterized by rapid proliferation, early metastatic dissemination, and poor long-term survival despite initial sensitivity to therapy. SCL...

Cu, a common essential trace element in the human body, is involved in multiple physiological and pathological processes. Cuproptosis, a recently proposed form of cell death, is triggered by Cu overload. It primarily tar...

Background: Non-small cell lung cancer (NSCLC) is the most common subtype of lung cancer with a steady increase in incidence. Purpose: This study aimed to confirm the role of LINC01583 on NSCLC progression and Osimertini...

Background and objectives: Tumors are complex systems characterized by variations across genetic, transcriptomic, phenotypic, and microenvironmental levels. This study introduced a novel framework for quantifying cancer ...

Abstract Dormant cancer cells are a significant source of cancer recurrence and metastasis and exhibit robust resistance to conventional therapies. Therefore, the exploration of novel therapeutic strategies to eliminate ...

Here, we identify a novel signaling pathway in which Rnd3 regulates the metastatic potential of lung cancer cells. Understanding this pathway could be leveraged to target metastatic disease. Rnd3 regulates cellular proce...

Abstract BCL-2 has been implicated in prostate cancer (PCa) progression and development of castration-resistant disease (CRPC); however, it remains unclear how the BCL-2- and AR-expressing PCa cell populations evolve acr...

Abstract Neutrophil extracellular traps (NETs), the DNA-protein structures released by neutrophils within the tumor microenvironment (TME), play a role in cancer that extends far beyond their traditional antimicrobial fu...

Abstract Background Head and neck squamous cell carcinoma (HNSCC) is a prevalent and aggressive malignancy with limited prognostic markers. Ubiquitin-specific peptidase 33 (USP33) has emerged as a potential modulator of ...

Targeted delivery of drugs to tumor cells, which circumvent resistance mechanisms and induce cell killing, is a lingering challenge that requires innovative solutions. Here, we provide two bioengineered strategies in whi...

Extracellular matrix (ECM) represents more than a mere intercellular cement. It is physiologically active in cell communication, adhesion and proliferation. Collagen is the most abundant protein, making up to 90% of ECM,...

IntroductionHead and neck cancer (HNC) is a major global health issue, often linked to smoking, alcohol, and viruses (HPV, EBV). HPV-driven oropharyngeal squamous cell carcinoma (OPSCC) showed distinct biology and better...

Emmanuel Ifeanyi Obeagu1– 3 1Division of Haematology, Department of Biomedical and Laboratory Science, Africa University Mutare, Mutare, Zimbabwe; 2Department of Molecular Medicine and Haematology, School of Pathology,...

BackgroundCancer cell evasion of the immune response is critical to cancer development and metastases. Clinicians' ability to kickstart the immune system to target these rogue cells is an ever-growing area of research an...

Abstract Head and neck squamous cell carcinoma (HNSCC) is a highly heterogeneous malignancy with limited predictive markers to guide personalized treatment, particularly in human papillomavirus (HPV)-negative cases, whic...

Background Despite expanding therapeutic options, the prognosis of lung squamous cell carcinoma (LUSC) remains poor. Immune checkpoint inhibitors benefit only a subset of patients, and epithelial–mesenchymal transition...

Abstract Background Epithelial ovarian cancer (EOC) is a highly heterogeneous malignancy with significant morbidity and mortality, and cisplatin (DDP) resistance remains a major obstacle in its treatment. Previous studie...

Liver hepatocellular carcinoma (LIHC) is an aggressive cancer associated with chronic liver disease, necessitating better biomarkers and therapies. Manganese, an essential trace element, regulates tumor development. Data...

Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype with limited targeted treatment options. Ferroptosis has emerged as a potential therapeutic vulnerability in TNBC, but its upstream regulation r...

Colorectal cancer (CRC) ranks third in incidence among all malignancies and is highly lethal in advanced stages. Combination chemotherapy regimens based on 5-fluorouracil (5-FU) remain the mainstay of colorectal cancer t...

Bladder cancer is a highly malignant tumor with limited treatment options. Although adoptive cell therapy has shown promise in oncology, its efficacy is often constrained by poor intrinsic antitumor activity and a highly...