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Inflammation-related diseases, including cardiovascular diseases, immune disorders, and infectious diseases, have high prevalence and disability rates, imposing heavy socioeconomic and healthcare burdens. Thus, elucidati...

Abstract Background To investigate the current status of public education on endocrine and metabolic diseases through WeChat official accounts (WOAs) of academic medical journals in China and to identify the factors that...

BackgroundClimate change is increasingly recognized as a critical driver affecting the transmission and distribution of parasitic diseases. However, a comprehensive synthesis of the global research landscape in this inte...

Abstract Background Periodontal disease exhibits bidirectional associations with autoimmune diseases; however, comprehensive histological, radiographic, and correlational differences in periodontal tissues between patien...

Introduction: In recent years, the prevalence of atopic diseases among children has increased. Increasing evidence suggests that early gut microbiota development, shaped in part by the mode of delivery, feeding practices...

Abstract Background Timely diagnosis and therapeutic management of rare diseases (RDs) are greatly hampered by limited clinical information and a lack of reliable epidemiological data. RDs constitute a heterogeneous grou...

Growing evidence has directly linked the gastrointestinal tract, gut microbiota, and central nervous system, forming the gut-brain axis, a process that has been described as a key mechanism in regulating neurological pro...

Purit Pureesrisak,1,2 Oraya Kwangsukstid,1 Pinnaree Kattipathanapong,1 Tanawatt Kootiratrakarn,1 Chonlaphat Sukasem,3 Dumrong Mairiang,4,5 Wenika Channakorn,1 Daraka Phainupong,1 Mingkwan Suphannaphong1 1Institute of Der...

Introduction: The neonatal period is one of the most critical phases in an individual’s life. During this time, newborns undergo significant physiological changes as they adapt from the intrauterine to the extrauterine...

Lucie Bartova,1 Mara Lisa Beuster,2 Bruno Bonetti,3 Giuseppe Maina,4,5 Pedro Morgado,6 Johan Nyberg7 1Department of Psychiatry and Psychotherapy, Clinical Division of General Psychiatry, and Comprehensive Center for Clin...

The peroxisome proliferator-activated receptors (PPARs), including PPAR-α, PPAR-β/δ, and PPAR-γ, are nuclear receptors that play critical roles in regulating metabolism and inflammation. While PPARs have been extensi...

Background: Metal-associated free fatty acids (FFAs) on cardiometabolic diseases have rarely been studied. Objective: To investigate metallomics-FFAs relationship, and identify FFAs as potential mediators linking metals ...

Janus kinase (JAK) inhibitors represent a major advancement in the management of immune-mediated inflammatory diseases. A balanced approach that carefully weighs therapeutic benefits against potential risks is essential....

In this research, we address a critical problem for strawberry growers in Lima: the management of phytosanitary diseases. Traditionally, these farmers relied on time-consuming, imprecise, and error-prone visual observati...

Abstract Immune system dysregulation is implicated in a wide range of human diseases, including cancer. Genetic studies have shown evidence of a link between immune diseases and cancer; therefore, deficits of immune syst...

Abstract Background The European Reference Network for rare Inherited and Congenital Anomalies (ERNICA) aims to improve care for patients with rare and complex digestive and gastrointestinal diseases across Europe throug...

Kai Chen,1,* Yiqing Nong,1,* Ying Liu,2 Ziming Ye3 1Department of Neurology, Guangxi Medical University Kaiyuan Langdong Hospital, Nanning, 530023, People’s Republic of China; 2Department of Rehabilitat...

Xianhui Ran,1,* Zhiyuan Fan,1,* Na Wang,1,* Tianyi Zhao,1 Hui Li,1 Xiao Liu,2 Enying Gong,3 Shuanghua Xie,4 Beiyao Gao,5 Lan An,6 Gang Chen,1 Xiao Ma,1,7 Chen Wang3,7 1Health Checkup Center, China...

In the central nervous system (CNS), programmed cell death (PCD) of neurons, is precisely regulated by various biomolecules to maintain neuronal development, establish neural structures, and maintain CNS homeostasis. Und...

Abstract Purpose Eating disorders (EDs) among women of childbearing age (WCBA; defined by the World Health Organization as women aged 15–49 years) have emerged as a significant public health concern on a global scale. ...

Abstract Background Discordance between small dense low-density lipoprotein cholesterol (sdLDL-C) and low-density lipoprotein cholesterol (LDL-C) levels is common. Whether this easily calculated parameter, derived from r...

Abstract Background Epidemiological data consistently associate low vitamin D status with elevated cardiovascular risk, yet causal mechanisms remain contested. Methods This review synthesized evidence through a protocol-...

Abstract Background Proper eating/fasting cycle can regulate circadian rhythms, thereby influencing metabolic regulation, oxidative stress, and cognitive function. However, its association with overall health remains und...

IntroductionWhilst individually rare, affecting only a small percentage of the population, rare diseases as a whole impact around 6% of the global population (with this number likely an underestimate). Rare diseases are ...