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Abstract Introduction Brazil is one of the countries with the highest rates of alcohol-related traffic infractions, but little is known about the profile of the drivers who commit them. Identifying the characteristics ...

O crescente consumo de drogas no Brasil atinge uma população cada vez mais jovem, inclusive estudantes. Os levantamentos epidemiológicos realizados entre alunos brasileiros de educação básica concluíram que a gran...

The multidrug resistance-associated protein 2 (MRP2/ABCC2) is a transporter that belongs to the ATP-binding cassette (ABC) superfamily. In the intestine, it is localized to the apical membrane of the enterocyte and plays...

The free-living nematode Caenorhabditis elegans has emerged as a powerful model for the study of the nervous system and human diseases and as a model for antiparasitic drug discovery. This nematode has also shown promise...

Abstract Breast cancer remains one of the most prevalent malignant tumors affecting women worldwide and continues posing a major threat to global health. Current clinical treatments include surgery, chemotherapy, radioth...

With the widespread application of chemotherapy, immunotherapy, and targeted therapy, cardiotoxicity associated with anti-tumor treatment has gained increasing attention. Drug-induced cardiac injury can significantly imp...

Abstract Background The global rise of extensively drug-resistant Acinetobacter baumannii, particularly biofilm-forming strains, has drastically limited treatment options and created an urgent need for novel therapies to...

Materias / palabras clave: accomplishment; chemoinformatics; computer-aided drug design; impact factor; metric; science practitioners

Abstract Background Lymphatic filariasis (LF) is a vector-borne parasitic disease that is being targeted for elimination through mass drug administration (MDA). The co-distribution of Loa loa in Central Africa poses a si...

ObjectiveGlucagon-like peptide-1 (GLP-1) receptor agonists have emerged as a therapeutic strategy for reducing drug craving and intake. However, their efficacy in methamphetamine use disorder remains unexplored. This stu...

The outbreak of COVID-19, the disease caused by SARS-CoV-2, continues to affect millions of people around the world. The absence of a globally distributed effective treatment makes the exploration of new mechanisms of ac...

Hand eczema is a common skin disorder with significant functional and economic impacts. Conventional therapy options, such as topical corticosteroids, calcineurin inhibitors, phototherapy and systemic immunosuppressants,...

Abstract Background Curcumin is one such polyphenol that has low bioavailability as well as solubility. Therefore, the present study has analyzed, investigated, and estimated the antimicrobial, antioxidant, and anticance...

The frequent rise of antibiotic-resistant bacteria is due to the increasing use of antibiotics in the healthcare system. Probiotics could offer a potential alternative, although their efficacy tends to be diminished in t...

Abstract The rapid emergence of multidrug-resistant (MDR) bacteria poses a critical challenge in hospital-acquired infections, particularly methicillin-resistant Staphylococcus aureus (MRSA) pneumonia. Antimicrobial pept...

Aging is an irreversible and natural phenomenon. At the biological level, aging is caused by various molecular and cellular damages over time. Evidence of Anti-aging were observed in Yeast, Worms and Mice with metformin....

Background. Viral infections remain a major global health threat despite advances in vaccines and antiviral drugs due to the rapid emergence of resistance and new viral pathogens. Antiviral peptides (AVPs) are promising ...

Antimalarial drugs used in medicine for over 300 years, nowadays, due to their anti-inflammatory, immunomodulatory and antiproliferative photoprotective properties, are used in the therapy of many dermatologic and rheuma...

Parasitic nematodes of humans and animals cause dis- eases of major socio-economic importance globally. Con- trol of infections in both human and veterinary medicine currently relies mainly on chemotherapy, but resistanc...

ABSTRACT Antimicrobial Growth Promoters (AGPs) have been phased out due to their link to antibiotic resistance. While their exact mode of action remains unknown, they are thought to reduce inflammation in the gut. This s...

BackgroundGlioblastoma (GBM) remains a lethal brain tumor with limited therapeutic options and near-universal recurrence. Drug repurposing offers a practical strategy, but pleiotropic compounds require systematic target ...

Abstract The advancement of sustained-release drug delivery systems is profoundly reshaping the medicinal applications. This study highlights a novel approach to developing sustained-release esterase responsive drug deli...

Zi-Xiu Gou, Ning-Wei Li, Jun-Yi Yao, Yun-Liang Wang Department of Gastroenterology, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, People’s Republic of ChinaCorrespondence: Yun-Liang Wang, Departme...

Abstract Quality defects in substandard medicines represent a threat to public health. Rapid and accurate identification of these defects is critical to prioritise the cases and implement regulatory measures. However, th...