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Efficacy and safety of Chinese botanical drug decoctions for migraine: a Bayesian network meta-analysis
Artículo
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Efficacy and safety of Chinese botanical drug decoctions for migraine: a Bayesian network meta-analysis
Fan Zhang et al · Frontiers Media S.A · 2026 · ISSN 1663-9812
BackgroundMigraine is a common neurological disorder that substantially affects patients’ quality of life. Chinese botanical drug decoctions are used in migraine management; however, the comparative efficacy and safety...
LCC LCC:Therapeutics. PharmacologyIdioma eng
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Efficacy of paraspinal anesthetic block in patients with chronic pelvic pain refractory to drug therapy: a randomized clinical trial
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Efficacy of paraspinal anesthetic block in patients with chronic pelvic pain refractory to drug therapy: a randomized clinical trial
Karen Felix da Rosa et al · Federação Brasileira das Sociedades de Ginecologia e Obstetrícia · 2015 · ISSN 0100-7203
PURPOSE: To determine whether paraspinal block reduces pain scores compared to placebo in women with chronic pelvic pain refractory to drug therapy.METHODS: Subjects with chronic pelvic pain due to benign conditions and ...
LCC TENDOkd5bmVjb2xvZ3kgYW5kIG9ic3RldHJpY3M~Idioma eng
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Efficacy and safety of artemether-lumefantrine (AL) and artesunate-amodiaquine (ASAQ) for the treatment of uncomplicated Plasmodium falciparum malaria among children 6–59 months in three sentinel sites of Sierra Leone, 2021–2022
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Efficacy and safety of artemether-lumefantrine (AL) and artesunate-amodiaquine (ASAQ) for the treatment of uncomplicated Plasmodium falciparum malaria among children 6–59 months in three sentinel sites of Sierra Leone, 2021–2022
Irene Cavros et al · BMC · 2026 · ISSN 1475-2875
Abstract Antimalarial drug resistance leads to increased treatment failures, prolonged illness, and increased mortality. The World Health Organization (WHO) recommends malaria-endemic countries regularly (ideally biennia...
LCC TENDOkFyY3RpYyBtZWRpY2luZS4gVHJvcGljYWwgbWVkaWNpbmU~; TENDOkluZmVjdGlvdXMgYW5kIHBhcmFzaXRpYyBkaXNlYXNlcw~~Idioma eng
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Efficacy analysis of disitamab vedotin (RC-48) in the treatment of HER2-low metastatic breast cancer: a case report
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Efficacy analysis of disitamab vedotin (RC-48) in the treatment of HER2-low metastatic breast cancer: a case report
Ruiyue Wu et al · Frontiers Media S.A · 2026 · ISSN 2234-943X
HER2-low breast cancer, defined as immunohistochemistry (IHC) 1+ or 2+ with negative in situ hybridization (ISH), has emerged as a clinically relevant therapeutic subgroup. We report the case of a 40-year-old woman with ...
LCC TENDOk5lb3BsYXNtcy4gVHVtb3JzLiBPbmNvbG9neS4gSW5jbHVkaW5nIGNhbmNlciBhbmQgY2FyY2lub2dlbnM~Idioma eng
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Efficacy and Safety of Glecaprevir/Pibrentasvir in Participants with Chronic HCV Infection and Comorbidities or Multiple Concomitant Medications: An Integrated Analysis
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Efficacy and Safety of Glecaprevir/Pibrentasvir in Participants with Chronic HCV Infection and Comorbidities or Multiple Concomitant Medications: An Integrated Analysis
Curtis Cooper et al · Adis, Springer Healthcare · 2026 · ISSN 2193-8229
Abstract Introduction Glecaprevir/pibrentasvir (G/P) is globally approved for the treatment of chronic hepatitis C virus (HCV) infection and for acute HCV infection in the USA. The efficacy and safety of G/P has been cl...
LCC TENDOkluZmVjdGlvdXMgYW5kIHBhcmFzaXRpYyBkaXNlYXNlcw~~Idioma eng
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Efficacy of cilastatin sodium in a translational large animal crush syndrome model
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Efficacy of cilastatin sodium in a translational large animal crush syndrome model
Adam C. Munhall et al · Nature Portfolio · 2026 · ISSN 2730-664X
Abstract Background Crush syndrome (consisting of hyperkalemia, acidosis, hypocalcemia, and acute kidney injury), is the second-most common cause of death in earthquakes, and a frequent cause of critical illness after bu...
LCC LCC:MedicineIdioma eng
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Efficacy of probiotic supplementation in reducing primary dysmenorrhea: a double-blinded randomized controlled trial
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Efficacy of probiotic supplementation in reducing primary dysmenorrhea: a double-blinded randomized controlled trial
Orawin Vallibhakara et al · Nature Portfolio · 2026 · ISSN 2045-2322
Abstract Primary dysmenorrhea is painful menstruation in the absence of pelvic pathology, whereas secondary dysmenorrhea is menstrual pain attributable to an underlying pelvic disease (e.g., endometriosis). Nonsteroidal ...
LCC LCC:Medicine; TENDOlNjaWVuY2U~Idioma eng
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The efficacy and safety of cannabidiol as adjunct treatment for drug‐resistant idiopathic epilepsy in 51 dogs: A double‐blinded crossover study
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The efficacy and safety of cannabidiol as adjunct treatment for drug‐resistant idiopathic epilepsy in 51 dogs: A double‐blinded crossover study
Aaron J. Rozental et al · Oxford University Press · 2023 · ISSN 0891-6640
Abstract Background Approximately 30% of dogs with idiopathic epilepsy (IE) are drug‐resistant. Recent studies have suggested cannabidiol (CBD) may be an effective anticonvulsant in dogs with IE. Objective To evaluate ...
LCC TENDOlZldGVyaW5hcnkgbWVkaWNpbmU~Idioma eng
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A comprehensive review of nanotechnology based drug delivery systems for osteoarthritis treatment
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A comprehensive review of nanotechnology based drug delivery systems for osteoarthritis treatment
Adikari Clawdia et al · De Gruyter · 2026 · ISSN 2191-9097
The complex etiology and short-term positive effects of treatments for osteoarthritis (OA) remain a significant challenge globally. The lack of approved disease-modifying OA drugs (DMOADs) and the rapid clearance of intr...
LCC TENDOlRlY2hub2xvZ3k~; TENDOkNoZW1pY2FsIHRlY2hub2xvZ3k~; TENDOlBoeXNpY2FsIGFuZCB0aGVvcmV0aWNhbCBjaGVtaXN0cnk~Idioma eng
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Cervical human papillomavirus: the therapeutic target of botanical drugs
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Cervical human papillomavirus: the therapeutic target of botanical drugs
Yan-Cai Tang et al · Frontiers Media S.A · 2026 · ISSN 1663-9812
Persistent cervical human papillomavirus (HPV) infection is the key biological event underlying high-grade squamous intraepithelial lesions, cervical cancer development, and recurrence risk. Botanical drugs and their bio...
LCC LCC:Therapeutics. PharmacologyIdioma eng
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Clinical efficacy, safety, and predictors of treatment response to SGLT2 versus DPP-4 inhibitors in type 2 diabetes: a retrospective comparative study
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Clinical efficacy, safety, and predictors of treatment response to SGLT2 versus DPP-4 inhibitors in type 2 diabetes: a retrospective comparative study
Xinfeng Yao et al · Frontiers Media S.A · 2026 · ISSN 1664-2392
BackgroundThe prevalence of type 2 diabetes is continuously increasing, and optimizing the treatment strategies for diabetes is an important clinical issue. SGLT2 inhibitors (SGLT2i) and DPP-4 inhibitors (DPP-4i) are two...
LCC LCC:Diseases of the endocrine glands. Clinical endocrinologyIdioma eng
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Epigenetic modifications in cancer drug resistance: molecular mechanisms and therapeutic interventions
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Epigenetic modifications in cancer drug resistance: molecular mechanisms and therapeutic interventions
Jingyi Yang et al · Springer · 2026 · ISSN 2662-8651
Abstract Therapeutic resistance remains a major cause of treatment failure and disease recurrence across cancer types, considerably limiting the long-term efficacy of chemotherapies, targeted therapies, and immunotherapi...
LCC LCC:MedicineIdioma eng
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Innovative ethosomal nanocarriers for transdermal delivery of antifungal agents: A systematic review of physicochemical advances to overcome drug resistance
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Innovative ethosomal nanocarriers for transdermal delivery of antifungal agents: A systematic review of physicochemical advances to overcome drug resistance
Karishma Mahajan et al · Elsevier · 2026 · ISSN 2666-9781
Invasive fungal infections remain a major cause of global morbidity and mortality, with resistance to conventional antifungal agents posing an increasing challenge. Ethosomal nanocarriers have gained attention as effecti...
LCC TENDOlRlY2hub2xvZ3k~Idioma eng
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Intestinal permeability of lamivudine (3TC) and two novel 3TC prodrugs. Experimental and theoretical analyses
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Intestinal permeability of lamivudine (3TC) and two novel 3TC prodrugs. Experimental and theoretical analyses
Gualdesi, María Soledad et al · Elsevier Science · 2012 · ISSN 0928-0987
Lamivudine (3TC) is an antiviral drug used to treat Acquired Immunodeficiency Syndrome (AIDS) in humans with a vastly demonstrated clinical efficacy. However the rapid emergence of resistant viral strains limits its effi...
Idioma eng
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Modulation of expression and activity of intestinal multidrug resistance-associated protein 2 by xenobiotics
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Modulation of expression and activity of intestinal multidrug resistance-associated protein 2 by xenobiotics
Tocchetti, Guillermo Nicolás et al · Academic Press Inc Elsevier Science · 2016 · ISSN 0041-008X
The multidrug resistance-associated protein 2 (MRP2/ABCC2) is a transporter that belongs to the ATP-binding cassette (ABC) superfamily. In the intestine, it is localized to the apical membrane of the enterocyte and plays...
Idioma eng
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Nanotherapeutic approaches to overcome distinct drug resistance barriers in models of breast cancer
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Nanotherapeutic approaches to overcome distinct drug resistance barriers in models of breast cancer
Saha Tanmoy et al · Wiley · 2021 · ISSN 2192-8614
Targeted delivery of drugs to tumor cells, which circumvent resistance mechanisms and induce cell killing, is a lingering challenge that requires innovative solutions. Here, we provide two bioengineered strategies in whi...
LCC TENDOlBoeXNpY3M~Idioma eng
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Remediation of poultry wastewater contaminated with multi-drug-resistant Pseudomonas aeruginosa using Triazole-modified MIL-53(Fe)
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Remediation of poultry wastewater contaminated with multi-drug-resistant Pseudomonas aeruginosa using Triazole-modified MIL-53(Fe)
Sahar A. Abdel Aziz et al · SpringerOpen · 2026 · ISSN 2314-8543
Abstract Background Multi-drug-resistant spectrum of Pseudomonas aeruginosa (P. aeruginosa) is frequently issue in wastewater of poultry industry, posing a major public hazard. Also, the incorporation of promising nano-s...
LCC TENDOk1lZGljaW5lIChHZW5lcmFsKQ~~; TENDOlNjaWVuY2U~Idioma eng
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Research progress on the prevention and treatment of drug-induced myocardial injury related to anti-tumor therapy with Chinese traditional medicine
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Research progress on the prevention and treatment of drug-induced myocardial injury related to anti-tumor therapy with Chinese traditional medicine
Yanan Gu et al · Shanghai Chinese Clinical Medicine Press Co., Ltd · 2026 · ISSN 1008-6358
With the widespread application of chemotherapy, immunotherapy, and targeted therapy, cardiotoxicity associated with anti-tumor treatment has gained increasing attention. Drug-induced cardiac injury can significantly imp...
LCC LCC:MedicineIdioma eng
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Surface-modified nanocarriers in the design of targeted drug delivery systems for parasitic diseases: a comprehensive review
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Surface-modified nanocarriers in the design of targeted drug delivery systems for parasitic diseases: a comprehensive review
Chinekwu S. Nwagwu et al · BMC · 2026 · ISSN 2661-801X
Abstract Parasitic diseases such as malaria, leishmaniasis, and schistosomiasis remain difficult to treat due to the pathogens’ complex life cycles, intracellular niches, and resistance to conventional therapies. Tradi...
LCC TENDOkNoZW1pc3RyeQ~~Idioma eng
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The evolving landscape of first-line and subsequent therapies in EGFR-mutated NSCLC: efficacy, resistance, and tolerability
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The evolving landscape of first-line and subsequent therapies in EGFR-mutated NSCLC: efficacy, resistance, and tolerability
Carminia Maria Della Corte et al · Open Exploration Publishing Inc · 2026 · ISSN 2692-3114
The treatment paradigm for advanced non-small cell lung cancer (NSCLC) harboring EGFR mutations is undergoing a significant transition. While third-generation tyrosine kinase inhibitors (TKIs) like osimertinib have long ...
LCC LCC:Internal medicineIdioma eng
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Unlocking p-coumaric acid’s potential against biofilm-forming extensively drug-resistant Acinetobacter baumannii: in vitro and in vivo study
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Unlocking p-coumaric acid’s potential against biofilm-forming extensively drug-resistant Acinetobacter baumannii: in vitro and in vivo study
Noha A. Attia et al · BMC · 2026 · ISSN 1476-0711
Abstract Background The global rise of extensively drug-resistant Acinetobacter baumannii, particularly biofilm-forming strains, has drastically limited treatment options and created an urgent need for novel therapies to...
LCC LCC:Therapeutics. Pharmacology; TENDOkluZmVjdGlvdXMgYW5kIHBhcmFzaXRpYyBkaXNlYXNlcw~~; TENDOk1pY3JvYmlvbG9neQ~~Idioma eng
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Clinical efficacy and tolerability of zonisamide monotherapy in dogs with newly diagnosed idiopathic epilepsy: Prospective open‐label uncontrolled multicenter trial
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Clinical efficacy and tolerability of zonisamide monotherapy in dogs with newly diagnosed idiopathic epilepsy: Prospective open‐label uncontrolled multicenter trial
Miyoko Saito et al · Oxford University Press · 2024 · ISSN 0891-6640
Abstract Background Zonisamide (ZNS) is a newer generation antiseizure medication (ASM) used to treat epilepsy in dogs and cats. However, scientific and clinical information, particularly regarding monotherapy, is limite...
LCC TENDOlZldGVyaW5hcnkgbWVkaWNpbmU~Idioma eng
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Measure the antimicrobial efficacy of the diosaginin compound isolated from the calves of the medical plant stalks ring Trigonellafoenunz-graecu
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Measure the antimicrobial efficacy of the diosaginin compound isolated from the calves of the medical plant stalks ring Trigonellafoenunz-graecu
Luma Salih et al · University of Mosul, College of Education for Pure Science · 2007 · ISSN 1812-125X
This assay pinafore measurement the potency of antibacterial of purified diosgenin compound :vhich isolated from stem callus of Trigone/la foenum-graecum . Diffusion method in petri dish was used for measuring the pot...
LCC TENDOkVkdWNhdGlvbg~~; LCC:Science (General)Idioma eng
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Anti-obesity drugs alone or combined with exercise training in the management of obesity: a systematic review with meta-analysis
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Anti-obesity drugs alone or combined with exercise training in the management of obesity: a systematic review with meta-analysis
Marmett Bruna et al · De Gruyter · 2025 · ISSN 2942-6812
Here we compare the efficacy of anti-obesity drugs alone or combined with exercise training on body weight and exercise capacity of obese patients. Randomized clinical trials that assessed the impact of any anti-obesity ...
LCC LCC:Medicine; TENDOlNwb3J0cw~~Idioma eng
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