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56 resultados encontrados.

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Efficacy and safety of Chinese botanical drug decoctions for migraine: a Bayesian network meta-analysis
Artículo
Acceso abierto Artículo DOAJ
Efficacy and safety of Chinese botanical drug decoctions for migraine: a Bayesian network meta-analysis
Fan Zhang et al · Frontiers Media S.A · 2026 · ISSN 1663-9812
BackgroundMigraine is a common neurological disorder that substantially affects patients’ quality of life. Chinese botanical drug decoctions are used in migraine management; however, the comparative efficacy and safety...
LCC LCC:Therapeutics. PharmacologyIdioma eng
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Efficacy and safety of artemether-lumefantrine (AL) and artesunate-amodiaquine (ASAQ) for the treatment of uncomplicated Plasmodium falciparum malaria among children 6–59 months in three sentinel sites of Sierra Leone, 2021–2022
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Efficacy and safety of artemether-lumefantrine (AL) and artesunate-amodiaquine (ASAQ) for the treatment of uncomplicated Plasmodium falciparum malaria among children 6–59 months in three sentinel sites of Sierra Leone, 2021–2022
Irene Cavros et al · BMC · 2026 · ISSN 1475-2875
Abstract Antimalarial drug resistance leads to increased treatment failures, prolonged illness, and increased mortality. The World Health Organization (WHO) recommends malaria-endemic countries regularly (ideally biennia...
LCC TENDOkFyY3RpYyBtZWRpY2luZS4gVHJvcGljYWwgbWVkaWNpbmU~; TENDOkluZmVjdGlvdXMgYW5kIHBhcmFzaXRpYyBkaXNlYXNlcw~~Idioma eng
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Efficacy analysis of disitamab vedotin (RC-48) in the treatment of HER2-low metastatic breast cancer: a case report
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Efficacy analysis of disitamab vedotin (RC-48) in the treatment of HER2-low metastatic breast cancer: a case report
Ruiyue Wu et al · Frontiers Media S.A · 2026 · ISSN 2234-943X
HER2-low breast cancer, defined as immunohistochemistry (IHC) 1+ or 2+ with negative in situ hybridization (ISH), has emerged as a clinically relevant therapeutic subgroup. We report the case of a 40-year-old woman with ...
LCC TENDOk5lb3BsYXNtcy4gVHVtb3JzLiBPbmNvbG9neS4gSW5jbHVkaW5nIGNhbmNlciBhbmQgY2FyY2lub2dlbnM~Idioma eng
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Efficacy and Safety of Glecaprevir/Pibrentasvir in Participants with Chronic HCV Infection and Comorbidities or Multiple Concomitant Medications: An Integrated Analysis
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Efficacy and Safety of Glecaprevir/Pibrentasvir in Participants with Chronic HCV Infection and Comorbidities or Multiple Concomitant Medications: An Integrated Analysis
Curtis Cooper et al · Adis, Springer Healthcare · 2026 · ISSN 2193-8229
Abstract Introduction Glecaprevir/pibrentasvir (G/P) is globally approved for the treatment of chronic hepatitis C virus (HCV) infection and for acute HCV infection in the USA. The efficacy and safety of G/P has been cl...
LCC TENDOkluZmVjdGlvdXMgYW5kIHBhcmFzaXRpYyBkaXNlYXNlcw~~Idioma eng
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Efficacy of cilastatin sodium in a translational large animal crush syndrome model
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Efficacy of cilastatin sodium in a translational large animal crush syndrome model
Adam C. Munhall et al · Nature Portfolio · 2026 · ISSN 2730-664X
Abstract Background Crush syndrome (consisting of hyperkalemia, acidosis, hypocalcemia, and acute kidney injury), is the second-most common cause of death in earthquakes, and a frequent cause of critical illness after bu...
LCC LCC:MedicineIdioma eng
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Efficacy of probiotic supplementation in reducing primary dysmenorrhea: a double-blinded randomized controlled trial
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Efficacy of probiotic supplementation in reducing primary dysmenorrhea: a double-blinded randomized controlled trial
Orawin Vallibhakara et al · Nature Portfolio · 2026 · ISSN 2045-2322
Abstract Primary dysmenorrhea is painful menstruation in the absence of pelvic pathology, whereas secondary dysmenorrhea is menstrual pain attributable to an underlying pelvic disease (e.g., endometriosis). Nonsteroidal ...
LCC LCC:Medicine; TENDOlNjaWVuY2U~Idioma eng
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A comprehensive review of nanotechnology based drug delivery systems for osteoarthritis treatment
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A comprehensive review of nanotechnology based drug delivery systems for osteoarthritis treatment
Adikari Clawdia et al · De Gruyter · 2026 · ISSN 2191-9097
The complex etiology and short-term positive effects of treatments for osteoarthritis (OA) remain a significant challenge globally. The lack of approved disease-modifying OA drugs (DMOADs) and the rapid clearance of intr...
LCC TENDOlRlY2hub2xvZ3k~; TENDOkNoZW1pY2FsIHRlY2hub2xvZ3k~; TENDOlBoeXNpY2FsIGFuZCB0aGVvcmV0aWNhbCBjaGVtaXN0cnk~Idioma eng
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Cervical human papillomavirus: the therapeutic target of botanical drugs
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Cervical human papillomavirus: the therapeutic target of botanical drugs
Yan-Cai Tang et al · Frontiers Media S.A · 2026 · ISSN 1663-9812
Persistent cervical human papillomavirus (HPV) infection is the key biological event underlying high-grade squamous intraepithelial lesions, cervical cancer development, and recurrence risk. Botanical drugs and their bio...
LCC LCC:Therapeutics. PharmacologyIdioma eng
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Clinical efficacy, safety, and predictors of treatment response to SGLT2 versus DPP-4 inhibitors in type 2 diabetes: a retrospective comparative study
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Clinical efficacy, safety, and predictors of treatment response to SGLT2 versus DPP-4 inhibitors in type 2 diabetes: a retrospective comparative study
Xinfeng Yao et al · Frontiers Media S.A · 2026 · ISSN 1664-2392
BackgroundThe prevalence of type 2 diabetes is continuously increasing, and optimizing the treatment strategies for diabetes is an important clinical issue. SGLT2 inhibitors (SGLT2i) and DPP-4 inhibitors (DPP-4i) are two...
LCC LCC:Diseases of the endocrine glands. Clinical endocrinologyIdioma eng
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Epigenetic modifications in cancer drug resistance: molecular mechanisms and therapeutic interventions
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Epigenetic modifications in cancer drug resistance: molecular mechanisms and therapeutic interventions
Jingyi Yang et al · Springer · 2026 · ISSN 2662-8651
Abstract Therapeutic resistance remains a major cause of treatment failure and disease recurrence across cancer types, considerably limiting the long-term efficacy of chemotherapies, targeted therapies, and immunotherapi...
LCC LCC:MedicineIdioma eng
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Innovative ethosomal nanocarriers for transdermal delivery of antifungal agents: A systematic review of physicochemical advances to overcome drug resistance
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Innovative ethosomal nanocarriers for transdermal delivery of antifungal agents: A systematic review of physicochemical advances to overcome drug resistance
Karishma Mahajan et al · Elsevier · 2026 · ISSN 2666-9781
Invasive fungal infections remain a major cause of global morbidity and mortality, with resistance to conventional antifungal agents posing an increasing challenge. Ethosomal nanocarriers have gained attention as effecti...
LCC TENDOlRlY2hub2xvZ3k~Idioma eng
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Remediation of poultry wastewater contaminated with multi-drug-resistant Pseudomonas aeruginosa using Triazole-modified MIL-53(Fe)
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Remediation of poultry wastewater contaminated with multi-drug-resistant Pseudomonas aeruginosa using Triazole-modified MIL-53(Fe)
Sahar A. Abdel Aziz et al · SpringerOpen · 2026 · ISSN 2314-8543
Abstract Background Multi-drug-resistant spectrum of Pseudomonas aeruginosa (P. aeruginosa) is frequently issue in wastewater of poultry industry, posing a major public hazard. Also, the incorporation of promising nano-s...
LCC TENDOk1lZGljaW5lIChHZW5lcmFsKQ~~; TENDOlNjaWVuY2U~Idioma eng
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Research progress on the prevention and treatment of drug-induced myocardial injury related to anti-tumor therapy with Chinese traditional medicine
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Research progress on the prevention and treatment of drug-induced myocardial injury related to anti-tumor therapy with Chinese traditional medicine
Yanan Gu et al · Shanghai Chinese Clinical Medicine Press Co., Ltd · 2026 · ISSN 1008-6358
With the widespread application of chemotherapy, immunotherapy, and targeted therapy, cardiotoxicity associated with anti-tumor treatment has gained increasing attention. Drug-induced cardiac injury can significantly imp...
LCC LCC:MedicineIdioma eng
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Surface-modified nanocarriers in the design of targeted drug delivery systems for parasitic diseases: a comprehensive review
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Surface-modified nanocarriers in the design of targeted drug delivery systems for parasitic diseases: a comprehensive review
Chinekwu S. Nwagwu et al · BMC · 2026 · ISSN 2661-801X
Abstract Parasitic diseases such as malaria, leishmaniasis, and schistosomiasis remain difficult to treat due to the pathogens’ complex life cycles, intracellular niches, and resistance to conventional therapies. Tradi...
LCC TENDOkNoZW1pc3RyeQ~~Idioma eng
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The evolving landscape of first-line and subsequent therapies in EGFR-mutated NSCLC: efficacy, resistance, and tolerability
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The evolving landscape of first-line and subsequent therapies in EGFR-mutated NSCLC: efficacy, resistance, and tolerability
Carminia Maria Della Corte et al · Open Exploration Publishing Inc · 2026 · ISSN 2692-3114
The treatment paradigm for advanced non-small cell lung cancer (NSCLC) harboring EGFR mutations is undergoing a significant transition. While third-generation tyrosine kinase inhibitors (TKIs) like osimertinib have long ...
LCC LCC:Internal medicineIdioma eng
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Unlocking p-coumaric acid’s potential against biofilm-forming extensively drug-resistant Acinetobacter baumannii: in vitro and in vivo study
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Unlocking p-coumaric acid’s potential against biofilm-forming extensively drug-resistant Acinetobacter baumannii: in vitro and in vivo study
Noha A. Attia et al · BMC · 2026 · ISSN 1476-0711
Abstract Background The global rise of extensively drug-resistant Acinetobacter baumannii, particularly biofilm-forming strains, has drastically limited treatment options and created an urgent need for novel therapies to...
LCC LCC:Therapeutics. Pharmacology; TENDOkluZmVjdGlvdXMgYW5kIHBhcmFzaXRpYyBkaXNlYXNlcw~~; TENDOk1pY3JvYmlvbG9neQ~~Idioma eng
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Autologous Ex Vivo Lentiviral Gene Therapy for Pediatric Patients with Severe Leukocyte Adhesion Deficiency-I Provides Sustained Efficacy with a Favorable Safety Profile
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Autologous Ex Vivo Lentiviral Gene Therapy for Pediatric Patients with Severe Leukocyte Adhesion Deficiency-I Provides Sustained Efficacy with a Favorable Safety Profile
Claire Booth et al · Rockefeller University Press · 2026 · ISSN 3065-8993
BackgroundSevere leukocyte adhesion deficiency-I (LAD-I) results from biallelic deleterious ITGB2 variants leading to deficient/defective CD18 leukocyte expression and impaired endothelial adhesion and extravasation.Chil...
LCC LCC:Immunologic diseases. AllergyIdioma eng
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BCR::ABL1‐Induced Enhancer Reprogramming Uncovers Hypersensitivity of Ph+B‐ALL Cells to Enhancer‐Targeting Drugs
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BCR::ABL1‐Induced Enhancer Reprogramming Uncovers Hypersensitivity of Ph+B‐ALL Cells to Enhancer‐Targeting Drugs
Han Leng Ng et al · Wiley · 2026 · ISSN 2198-3844
ABSTRACT Cancer is driven by genomic lesions and malignancy‐promoting transcriptional programs. In blood cancers, both are often interconnected as lesions frequently affect transcription factor (TF)‐encoding genes. T...
LCC TENDOlNjaWVuY2U~Idioma eng
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Disulfidptosis induced by intermittent fasting and metformin enhances the efficacy of anti-PD-1 therapy in renal cancer
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Disulfidptosis induced by intermittent fasting and metformin enhances the efficacy of anti-PD-1 therapy in renal cancer
Hongru Wang et al · BMC · 2026 · ISSN 1478-811X
Abstract PBRM1-mutant ccRCC is a subtype of ccRCC with limited treatment options. Currently, there were no effective drugs specifically targeting this mutation. Here, we discovered that PBRM1-mutant ccRCC patients with c...
LCC LCC:Medicine; LCC:CytologyIdioma eng
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GLP-1 agonist liraglutide decreases operant methamphetamine intake in rats under conditions of short- but not extended-access to the drug
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GLP-1 agonist liraglutide decreases operant methamphetamine intake in rats under conditions of short- but not extended-access to the drug
Maria Hrickova et al · Frontiers Media S.A · 2026 · ISSN 1663-9812
ObjectiveGlucagon-like peptide-1 (GLP-1) receptor agonists have emerged as a therapeutic strategy for reducing drug craving and intake. However, their efficacy in methamphetamine use disorder remains unexplored. This stu...
LCC LCC:Therapeutics. PharmacologyIdioma eng
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Interim Safety and Efficacy Outcomes of an Open-Label Long-Term Extension Study of Treatment with PI3Kδ Inhibitor Leniolisib in Pediatric Patients Aged 4-11 Years with Activated PI3Kδ Syndrome (APDS)
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Interim Safety and Efficacy Outcomes of an Open-Label Long-Term Extension Study of Treatment with PI3Kδ Inhibitor Leniolisib in Pediatric Patients Aged 4-11 Years with Activated PI3Kδ Syndrome (APDS)
V. Koneti Rao et al · Rockefeller University Press · 2026 · ISSN 3065-8993
Leniolisib, a selective PI3Kδ inhibitor, is a Food and Drug Administration (FDA)-approved treatment for activated PI3Kδ syndrome (APDS) in patients ≥12 years weighing ≥45 kg. To determine its impact on children, pa...
LCC LCC:Immunologic diseases. AllergyIdioma eng
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Overcoming Trypanosoma cruzi persistence with a mechanistically distinct drug combination
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Overcoming Trypanosoma cruzi persistence with a mechanistically distinct drug combination
Amanda Fortes Francisco et al · Nature Portfolio · 2026 · ISSN 2731-8745
Abstract Infections with the protozoan parasite Trypanosoma cruzi are widespread in the Americas and can lead to severe cardiac and/or gastrointestinal pathology. Current treatments are limited to monotherapies character...
LCC TENDOk1pY3JvYmlvbG9neQ~~Idioma eng
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Preclinical efficacy and safety evaluation of human embryonic stem cell-derived functional hepatocytes for a clinical trial in acute liver failure
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Preclinical efficacy and safety evaluation of human embryonic stem cell-derived functional hepatocytes for a clinical trial in acute liver failure
Yi Sun et al · BMC · 2026 · ISSN 1757-6512
Abstract Background Acute liver failure (ALF) is a life-threatening syndrome characterized by rapid deterioration of liver function, resulting in high mortality and posing a substantial global health burden. Human embryo...
LCC TENDOk1lZGljaW5lIChHZW5lcmFsKQ~~; TENDOkJpb2NoZW1pc3RyeQ~~Idioma eng
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QRNN-GRU framework for automatic argument and annotation extraction in medical drug reviews
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QRNN-GRU framework for automatic argument and annotation extraction in medical drug reviews
Eman Altameem et al · Nature Portfolio · 2026 · ISSN 2045-2322
Abstract Argument annotation in medical drug reviews is a challenging task due to noisy user-generated content, domain-specific terminology, and subjective expressions of medication efficacy and adverse effects. While ar...
LCC LCC:Medicine; TENDOlNjaWVuY2U~Idioma eng
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