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ObjectiveTo evaluate the association between adherence to adjuvant endocrine therapy and overall survival as well as breast cancer–specific survival in patients with hormone receptor–positive breast cancer, to charac...

Abstract Intraoperative nerve monitoring (IONM) provides real-time nerve feedback and easy identification, guiding surgical decisions in thyroid and parathyroid procedures. We assessed the practical implementation of the...

Abstract Background To investigate the current status of public education on endocrine and metabolic diseases through WeChat official accounts (WOAs) of academic medical journals in China and to identify the factors that...

Abstract Background Estrogen receptor alpha (ERα)-positive luminal breast cancer is commonly treated with aromatase inhibitors (AI) to block estrogen signaling; however, resistance frequently develops, limiting therapy ...

BackgroundBoth insulin and glucagon have been extensively studied due to their critical roles in glucose metabolism, development, and disease. However, there is limited information about the molecular characteristics of ...

Multiple epidemiological studies across countries have linked exposure to endocrine-disrupting chemicals (EDCs) with adverse reproductive outcomes; however, the underlying mechanisms remain incompletely characterized. In...

IntroductionAquatic light environments are increasingly altered by human activity, yet the endocrine and molecular mechanisms enabling fish to cope with extreme photoperiods remain poorly understood. This study investiga...

BackgroundCurrent guidelines recommend endocrine evaluation for infertile men; however, those with normal sperm concentration (≥15 million/mL) may be under-referred for comprehensive assessment. This study aimed to inv...

Di(2-ethylhexyl) phthalate (DEHP) is a commonly used plasticizer that has raised significant concerns due to its strong endocrine-disrupting effects, which are closely associated with developmental toxicity. While previo...

Midlife represents a biological “phenotype transition” for women, during which sarcopenic obesity risk can rise despite stable BMI. Evidence anchored to the STRAW + 10 framework suggests that the interval surroundi...

BackgroundPathogenic variants in melanocortin-4 receptor (MC4R) are the most common cause of nonsyndromic monogenic obesity. However, links between MC4R-related obesity and pubertal tempo, and the long-term endocrine–m...

Pyrethroid insecticides are widely used indoors in residential, commercial, and occupational pest-control settings and are generally regarded as safe because of their relatively low acute toxicity. This perception is lar...

Modern lifestyle factors, including dietary choices, significantly affect individual and intergenerational health. The widespread reliance on processed and takeout foods, along with the regular use of cosmetics and perso...

IntroductionDesmoid tumors, also known as aggressive fibromatosis, are rare, locally invasive soft tissue neoplasms characterized by clonal fibroblastic proliferation without metastatic potential. Gamma secretase inhibit...

Osteoporosis (OP), a widespread metabolic bone condition characterized by diminished bone mass and compromised microarchitecture, poses a significant global health challenge. The gut microbiota (GM) regulates bone homeos...

BackgroundCancer patients often face concurrent challenges of cancer-related cognitive impairment (CRCI) and opportunities for post-traumatic growth (PTG), but existing research primarily adopts a variable-centered appro...

Individuals who exhibit male external genitalia and testicular tissue despite a 46,XX karyotype with SRY-Negative represent an exceptionally rare phenotype of disorders of sex development (DSD), and the underlying mechan...

Abstract Background Neutrophils (polymorphonuclear leukocytes, PMNs) have long been underestimated in the context of autoimmunity. To elucidate their role from a sex-specific perspective, an immunoendocrinological framew...

BackgroundEarly detection of diabetic retinopathy (DR) remains challenging in primary care, where access to ophthalmic screening is limited. We developed and validated a prediction model using routinely collected health ...

IntroductionFamilial partial lipodystrophy (FPL) is a rare condition related to partial deficiency of adipose tissue and consequent insulin resistance resulting in metabolic alterations. Although type 2 diabetes mellitus...

ABSTRACT Aims/Introduction This study aimed to clarify the relationship between glucose metrics measured by continuous glucose monitoring (CGM) and diabetic retinopathy (DR) and albuminuria among Japanese individuals wit...

ABSTRACT Objectives To evaluate whether glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) are associated with improved survival and renal outcomes in patients with rheumatoid arthritis and type 2 diabetes, a po...