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Ganoderic acids (GAs), the major lanostane-type triterpenoids in Ganoderma lucidum (G. lucidum), possess diverse pharmacological activities but are produced at low levels, limiting their applications. Transcriptional reg...

To investigate the effects of magnetic stimulation mediated by magnetic/graphene (MNP/G) composite nanomaterials on human scleral fibroblast (HFSF) proliferation and collagen synthesis, exploring its potential for myopia...

The soybean cyst nematode (SCN), Heterodera glycines, remains the most damaging pathogen of soybean worldwide. Genomic advances over the past two decades have transformed our understanding of both the nematode and its ho...

Synthetic biology is emerging as a frontier interdisciplinary discipline that is increasingly regarded as a key driver of sustainable innovation in advanced materials. By leveraging the design-build-test-learn (DBTL) cyc...

Abstract Background Soil salinization severely restricts the growth and forage yield of Medicago sativa (alfalfa), a globally critical leguminous forage crop, yet the regulatory mechanisms governing its salt tolerance re...

Fine-scale heterogeneity in soil nutrient availability can enhance plant growth, yet its effect across soil depth remains inadequately understood. Communities with increased species diversity showed varying growth strate...

Abstract Psammochloa villosa is a perennial herbaceous plant belonging to tribe Stipeae (Poaceae). It is mainly distributed in the arid and sandy Inner Mongolia Plateau and adjacent areas, demonstrating remarkable resili...

Background: In multiple sclerosis (MS), chronic “smoldering” lesions are driven by microglial activation, which promotes demyelination and disease progression. However, microglia exhibit a functional dichotomy by per...

Abstract Background Ferns, comprising epiphytic, aquatic, and terrestrial varieties, are good models to investigate plant terrestrialization. Vascular tissue represents a significant development in the terrestrial adapta...

Abstract Dynamic regulation of lipid membrane composition is fundamental to living cells; however, synthetic analogs capable of such regulation remain scarce. Here, we present an artificial cell platform in which riboswi...

This study represents one of the first investigations of circular RNAs (circRNAs) in the ovaries of Tibetan sheep, with a focus on their potential role in reproductive performance. The aim was to identify circRNAs involv...

ABSTRACT Genome engineering plays a crucial role in the rapidly growing fields of metabolic engineering and synthetic biology. Chromosomal integration and stable expression of functional genes or large metabolic pathways...

BackgroundPrimary malignant bone tumors are aggressive neoplasms that frequently affect adolescents and young adults. Limb-sparing surgery (LSS) has become the preferred surgical approach when oncologically feasible; how...

Abstract Many sulfated polysaccharides (SPSs) possess useful physicochemical properties and biological activities and are widely used in industry. Currently, major SPSs are derived from livestock and marine organisms. To...

Carabids are important natural biocontrol agents for pest regulation in agricultural landscapes. Their role in the ecosystem is related to functional traits, which are themselves filtered by both the degree of habitat di...

Abstract Chenopodioideae plants are dominant components of desert ecosystems in arid regions of China and Central Asia and play key roles in maintaining ecosystem stability, while also providing valuable systems for unde...

Abstract Microorganisms play key roles in nutrient cycling and soil remediation in saline-alkaline ecosystems. However, how their assembly rules and interaction networks change during natural succession remains unclear. ...

Abstract The systematic exploration of novel bioactive compounds with superior functional properties is critical for driving innovations in agriculture, healthcare, and related fields, thereby becoming essential for adva...

Plasmodiophora brassicae, the obligate parasite responsible for clubroot in Brassica crops and other crucifers, poses a major challenge to sustainable disease management due to its biotrophic lifestyle and adaptability. ...

Cancer-associated fibroblasts (CAFs) are important stromal cells in the tumor microenvironment of lung adenocarcinoma (LUAD). This review discusses the different cellular sources of CAFs and the main signaling pathways i...

Abstract Cuproptosis is a recently identified copper-dependent cell death pathway with growing relevance in tumor biology, yet its involvement in thyroid carcinoma (TC) remains poorly understood. In this study, we integr...

Abstract Head and neck squamous cell carcinoma (HNSCC) is a highly heterogeneous malignancy with limited predictive markers to guide personalized treatment, particularly in human papillomavirus (HPV)-negative cases, whic...

Breast cancer bone metastasis causes severe complications, yet current radiotherapy has limitations in treating secondary metastases and protecting healthy tissues. This study introduces calcium gadolinium layered double...

Abstract Fibrous dysplasia (FD) is a rare disorder associated with fractures and deformities. FD lesions produce excess phosphaturic hormone fibroblast growth factor 23 (FGF23), leading to hyperphosphaturia in most patie...