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Globally, one major cause of morbidity and mortality is cardiovascular diseases (CVDs). The burden of cardiovascular disease among the elderly is still high and typically tends to move to nations with lower sociodemograp...

Background Observational studies have shown that endovascular thrombectomy (EVT) benefits patients with acute basilar artery occlusion (aBAO) in the ultra-late window, yet subgroups at high risk of unfavourable outcome r...

Vascular and metabolic diseases, including atherosclerosis, aortic aneurysm and dissection, obesity, type 2 diabetes, and metabolic dysfunction–associated steatotic liver disease (MASLD), constitute a major global heal...

Abstract The core pathological mechanisms of diabetic microvascular diseases, such as nephropathy, diabetic retinopathy (DR), and neuropathy, involve the dysfunction and loss of microvascular endothelial cells (ECs), vas...

BackgroundSystemic sclerosis (SSc) is characterized by a complex and heterogeneous interplay between vascular dysfunction, immune activation, and progressive fibrosis. Despite advances in molecular characterization, ther...

Background and objectiveEndothelial dysfunction is a key driver of cardiovascular complications in individuals with impaired glucose tolerance (IGT), with oxidative stress and inflammation playing pivotal roles in its pa...

Abstract Background Endothelial cells (ECs) orchestrate vascular homeostasis and resilience but can undergo reprogramming into a mesenchymal-like phenotype through an endothelial-to-mesenchymal transition (EndMT). Crucia...

Abstract Periodontitis has been increasingly recognized as a contributor to systemic diseases such as atherosclerosis due to its persistent inflammatory nature. The present study evaluates an innovative nanocomposite, LL...

Jiahui Zhang,1– 3,* Junran Tong,1– 3,* Yang Sun,4,* Jinpeng Sun,1– 3 Ran Gao,1– 3 Di Sun,5 Xiaopeng Guo,6 Yumiao Wei1– 3 1Department of Cardiology, Union Hospital, Tongji Medical College...

Abstract Angiogenesis and its maturation play a crucial role in the progression and prognosis of head and neck squamous cell carcinoma (HNSCC). Tumor growth relies on an adequate blood supply to meet metabolic demands, w...

Jiawei Zhao,1,* Yuting Gou,1,* Yiyang Wang,1,* Yongxiang Li,1 Haotian Ma,1 Yiting Xing,2 Haohao Peng,2 Chenming Guo1,3 1Department of Breast Surgery, Center of Digestive and Vascular, The First Af...

IntroductionElevated HbA1c levels, in combination with comorbidities such as diabetes and hypertension, have been linked to increased stroke severity, poorer functional recovery, and higher mortality. However, the predic...

Abstract Background As dementia cases continue to rise, effective prevention strategies are urgently needed. However, objective biomarkers that directly reflect lifestyle factors remain limited. Life’s Essential 8 (LE8...

BackgroundRecurrent bacterial pneumonia accompanied by atypical systemic findings may indicate an uncharacterized inborn error of immunity (IEI). We report a 10-year-old male with recurrent pneumonias, mildly low but fun...

Abstract Background Fat embolism syndrome (FES) is commonly associated with orthopedic trauma, but the diagnosis is challenging with an uncommon nontraumatic cause. It is difficult to discriminate from thrombo-embolism i...

Background Acute ischaemic stroke often leads to significant disability and mortality. Secondary brain injury caused by post-stroke immune and inflammatory responses worsens outcomes.Aim To assess the efficacy and safety...

Materias / palabras clave: congenital vascular diseases, degenerative vascular diseases, functional vascular diseases, inflammatory vascular diseases, neoplastic vascular diseases, traumatic vascular diseases; Medicine: Internal medicine: Specialt...