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Abstract Histone modifications and chromatin‐binding proteins play crucial roles in regulating gene expression in eukaryotes, with significant implications for fungal pathogenicity and development. However, profiling t...

In the zebra finch (Taeniopygia guttata) a germline-restricted chromosome (GRC) is regularly present in males and females. While the GRC is euchromatic in oocytes, in spermatocytes this chromosome is cytologically seen a...

Background: Nucleosomes are the building blocks of chromatin where gene regulation takes place. Chromatin landscapes have been profiled for several species, providing insights into the fundamental mechanisms of chromatin...

Materias / palabras clave: Histone code; Nucleosome; Chromatin; Histone; Computational biology; Cell biology; Histone H1; Biology; Epigenomics; Histone methyltransferase; Histone H2A; Histone-modifying enzymes

AbstractPsychostimulants regulate behavioral responses in zebrafish via epigenetic mechanisms. We have previously shown that DNAmethylation and histone deacetylase (HDAC) inhibition abolish nicotine-induced conditioned p...

Abstract Background Metabolic dysfunction-associated steatotic liver disease (MASLD) stands as the most widespread chronic liver disorder globally. Histone β-hydroxybutyrylation (Kbhb)—a novel post-translational modif...

Background: Histone methylation modifies the epigenetic state of target genes to regulate gene expression in the context of developmental and environmental changes. Previously, we used a positive genetic screen to identi...

Abstract Histone post-translational modifications epigenetically regulate gene expression by modulating nucleosome structure and DNA accessibility. This review outlines how unique patterns of modifications on canonical ...

Abstract Fungal histone methylation modification (HMM) includes methylation and demethylation at the histone lysine/arginine residues, which are catalyzed by the methyltransferases (HMTs) and demethylases (HDMs) of histo...

Abstract Therapeutic resistance remains a major cause of treatment failure and disease recurrence across cancer types, considerably limiting the long-term efficacy of chemotherapies, targeted therapies, and immunotherapi...

ABSTRACT Background The genome‐wide profiling of chromatin states that are defined by different histone posttranslational modifications, known as epigenomic profiling, is crucial for understanding the epigenetic regula...

Abstract Metastasis is the leading cause of cancer-related deaths. Understanding the molecular mechanism of tumor metastasis is of great significance to cancer research. However, the molecular diagnosis and treatment of ...

Nasopharyngeal carcinoma (NPC) is a metastasis-prone malignancy that is highly prevalent in endemic regions. Epigenetic dysregulation, including aberrant DNA/RNA/protein methylation, histone modifications, and non-coding...

Abstract Background Witches’ broom is an important disease of the Paulownia fortunei. Understanding the pathogenesis of witches’ broom is a prerequisite for its prevention and control. Phytoplasma is the pathogen of ...

Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease around the world, with at least 40% global prevalence. Although genetic susceptibility contributes to disease risk...

Post-translational modifications (PTMs) play pivotal roles in ovarian cancer pathogenesis, with poly(ADP-ribosyl)ation (PARylation) serving as a key regulator of DNA repair, immune evasion, and therapeutic resistance. Be...

Lysine lactylation (Kla) is a novel form of post-translational modification. It utilizes lactate as its core substrate. Through an enzymatic regulatory network, it mediates modifications of both histones and non-histone ...

Alternative splicing plays critical roles in differentiation, development, and disease and is a major source for protein diversity in higher eukaryotes. Analysis of alternative splicing regulation has traditionally focus...

In the context of climate change and the need to reduce pesticide and agrochemical use, the development of sustainable crops is becoming increasingly important. Epigenetic mechanisms, such as histone modifications, allow...

Identifying the factors that regulate female reproduction is crucial to understanding how the environment affects female reproductive health. The vitamin D receptor (VDR) and its ligands (primarily 1,25(OH)2D3) have a re...

Abstract Here, we review mathematical models of epigenetic memory, focusing on chromatin modifications as key mechanisms to achieve long-term maintenance of epigenetic states. After reviewing the main stochastic modeling...

Abstract Histone modifications by histone deacetylases (HDACs) are essential for controlling chromatin structure and regulating gene expression. Functionally, HDACs act as enzymatic subunits within diverse multisubunit c...

Given the widespread application of copper oxide nanoparticles (CuONPs), their biosafety has attracted significant attention. However their effects on the developmental capacity of mammalian preimplantation embryos and t...

Autism spectrum disorders (ASDs) are neuropsychiatric diseases characterized by impaired social interaction, communication deficits, and repetitive and stereotyped behaviors. ASD etiology is unknown, and both genetic and...