Buscar recursos académicos

Abstract Recent studies have demonstrated that exosome therapy can promote the recovery of ovaries in premature ovarian failure (POF) models, which may aid in fertility restoration. This study aimed to investigate the th...

Abstract Background Turner syndrome (TS) is a chromosomal disorder affecting growth, ovarian function, and pubertal development. This study evaluated the effects of estrogen replacement therapy (ERT) on growth, pubertal ...

Abstract Background Prolificacy is a crucial economic trait in goat production, yet its underlying molecular mechanisms remain incompletely understood due to its polygenic nature. While previous studies have identified s...

Yu Luo,1 Suning Huang,1,2 Haichuan Xie,3 Bei Zhang,3 Fei Ma,1– 4 Yanting Lin,1– 4 Yan Ning,1– 4 Jiaman Wu1– 4 1Graduate School, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, 510405, People’s R...

Abstract Ovarian cancer remains a significant global health burden, with high-grade serous ovarian cancer (HGSOC) representing the most lethal subtype. Bulk RNA-seq analysis revealed KLK5 (Kallikrein-5, a serine protease...

Abstract Hedyotis diffusa Willd (HD) and Scutellaria barbata D.Don (SB) are widely used traditional Chinese herbs with detoxifying properties and anti-tumor activities. The HD-SB pairing demonstrated significant anti-tum...

Abstract Background Given that sleep disturbance and fatigue are pervasive among patients with advanced ovarian cancer (OC) and associated with poor health-related quality of life (HRQoL), several patient-reported outcom...

Post-translational modifications (PTMs) play pivotal roles in ovarian cancer pathogenesis, with poly(ADP-ribosyl)ation (PARylation) serving as a key regulator of DNA repair, immune evasion, and therapeutic resistance. Be...

Abstract Objective Thyroid-stimulating hormone beta subunit (TSHB) gene, a member of the glycoprotein hormone beta subunit family, has been detected in ovarian tissues and granulosa cells (GCs) of several species, sugges...

Abstract Background The ecdysone receptor (EcR) is a central regulator of mosquito physiology, best known for its role in vitellogenesis. However, its contribution to antiviral defense and dengue virus (DENV) replication...

Everett Lwamulungi, Prisca Ibe, Dickson Ndukwe Otaka Department of Obstetrics and Gynaecology, Tamworth Rural Referral Hospital, Tamworth, NSW, AustraliaCorrespondence: Everett Lwamulungi, Email lwerett@gmail.comBackgrou...

Abstract Background Cumulus granulosa cells (CGCs) are essential for oocyte support, metabolic cooperation, and steroidogenesis, yet they deteriorate rapidly in conventional 2D culture, limiting long-term studies of thes...

Abstract Age-dependent reproductive decline has become a significant global health concern as the average maternal age at first birth increases. Fertility loss associated with reproductive aging is driven in part by alte...

Abstract Background V-domain immunoglobulin suppressor of T-cell activation (VISTA), an immune checkpoint protein, is overexpressed in multiple cancers. However, its mechanistic role in ovarian cancer (OC) remains largel...

This study represents one of the first investigations of circular RNAs (circRNAs) in the ovaries of Tibetan sheep, with a focus on their potential role in reproductive performance. The aim was to identify circRNAs involv...

Polycystic Ovarian Syndrome (PCOS) is a complex medical condition that impacts women’s bodies and identities, especially in relation to gendered expectations of health and femininity. Drawing on feminist and social con...

This study examined the effects of subclinical pregnancy toxemia (SPT) on follicular development and evaluated the protective potential of dietary L-carnitine supplementation in ewes. Eighteen crossbred Hamdani ewes unde...

IntroductionThe vertebrate nonapeptide vasotocin (Avp) is evolutionarily conserved and homologous to mammalian vasopressin. Previous work using avp-/- zebrafish demonstrated a role for Avp in female, but not male, zebraf...

ABSTRACT Background and Aims The present review aims to ascertain whether reproductive disorders are associated with specific physical, mental, personality, and social traits. This information may be used to support or r...

Abstract Publicly available, large-scale medical imaging datasets are crucial for developing and validating artificial intelligence (AI) models and conducting retrospective clinical research. However, multimodal datasets...

Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED/APS-1) is a monogenic disorder of failed central tolerance caused by deleterious variants in the autoimmune regulator (AIRE) gene. Interferon-γ-driv...

Lysine lactylation (Kla) is a novel form of post-translational modification. It utilizes lactate as its core substrate. Through an enzymatic regulatory network, it mediates modifications of both histones and non-histone ...

RationaleCancer remains one of the most formidable challenges in mordern medicine. Chemoresistance, particularly resistance to platinum-based agents, presents a major challenge in effective treatments. In response to thi...