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A sensitive and selective liquid chromatography tandem mass spectrometry (LC-MS/MS) method for determination of diphenhydramine hydrochloride in rabbit plasma was developed and validated. After addition of triazolam as i...

A sensitive and selective liquid chromatography-tandem mass spectrometry method (LC-MS/MS) for the determination of tolbutamide in rabbit plasma was developed and validated over the concentration range of 4-1000 ng mL-...

A simple and sensitive LC-ESI-MS method for determination of norvancomycin in plasma was developed and validated over the concentration range of 20-2,000 ng/mL. After addition of vancomycin as internal standard (IS), p...

A highly sensitive liquid chromatographic tandem mass spectrometric (LC-MS/MS) method for determination of dextromethorphan in rabbit plasma using triazolam as the internal standard (IS) was developed. Plasma samples wer...

HPLC-DAD was used and validated for the simultaneous determination of five flavonoids (rutin, quercitrin, quercetin, kaempferol and isorahamnetin) in rabbit plasma. Chromatographic separation was performed on an Aglient ...

A selective and sensitive liquid chromatography-tandem mass spectrometry method was developed and validated for quantitation of bupropion hydrochloride in rat plasma using triazolam as an internal standard. Chromatograph...

A sensitive and selective liquid chromatography-mass spectrometry (LC–MS) method for determination of esomeprazole in rabbit plasma was developed and validated. After addition of midazolam as internal standard (IS), pr...

A sensitive and selective liquid chromatography-mass spectrometry (LC-MS) method for determination of sulpiride in rabbit plasma was developed and validated. The analyte and internal standard (IS) were extracted from pla...

The objective of this study was to compare the pharmacokinetic characteristics of ascaridole following oral administration of pure ascaridole and Jinghuaweikang (JHWK) capsule. Besides, additional rats were given pure as...

A sensitive and selective liquid chromatography/electrospray mass spectrometry (LC-ESIMS) method for determination of troxerutin in rabbit plasma was developed. After addition of paeoniflorin as internal standard (IS), p...

A LC-MS method was developed and validated for simultaneous determination of 6, 7-di-hydroxyligustilide and gastrodin in rat plasma, and which was subsequently applied in the pharmacokinetic analysis of an administration...

Sujong Lee,1,2 Heejae Won,1,2 Kyung-Sang Yu,1,2 Dae Young Lee,3 SeungHwan Lee1 1Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Republic of Korea; ...

Developing effective drugs for Alzheimer’s Disease (AD) is critically limited by insufficient brain exposure. To address this, structural optimization was employed to balance physicochemical properties and enhance bloo...

Abstract Background The antibiotic resistance of Klebsiella pneumoniae poses significant challenges in veterinary clinical settings and threatens poultry production. Veterinarians often employ combination therapy to addr...

Abstract Carbon nanotubes (CNTs) are promising nanomaterials with applications in biomedicine, including drug delivery and biosensing, due to their stability, biocompatibility, and ease of surface modification. However, ...

Abstract Background Working dogs exposed to narcotics might require reversal in the field. Objective To explore the pharmacokinetic and pharmacodynamic effects of naloxone administered intramuscularly (IM) or intranasall...

Abstract Background The repeated administration of high doses of gabapentin may provide better analgesia in horses than current clinical protocols. Hypothesis and Objectives Administration of gabapentin at 40 and 120 m...

ABSTRACT Background Phenazopyridine is used for ancillary pain management in the treatment of goats with obstructive urolithiasis. However, there are no published studies on the pharmacokinetics, safety, or efficacy of p...

Abstract Cannabis and its primary psychoactive component, Δ9-tetrahydrocannabinol (THC), are increasingly studied for their pharmacological effects, yet little is known about their pharmacokinetics in non-human primates...

Abstract Objective Breast cancer remains a major cause of morbidity and mortality among Ugandan women, who often present at younger age with advanced disease. Doxorubicin is central to treatment regimens, but current dos...

Dosing immunoglobulin G (IgG) replacement therapy in primary immunodeficiency disease (PIDD) depends on IgG pharmacokinetics (PK) and patients’ clinical status. Conventionally, PK data used to determine dosing were bas...

IntroductionRespiratory syncytial virus (RSV) is a leading cause of lower respiratory tract infections, while effective therapeutic options remain limited. This study investigated the antiviral efficacy, pharmacokinetics...

In this study, healthy volunteers in Pakistan were asked to compare the single-dose pharmacokinetics of 16 mg of the angiotensin receptor blocker candesartan cilexetil following oral administration. Blood samples were ta...

Abstract Introduction Patients on hemodialysis (HD) are vulnerable to COVID-19 and often excluded from pivotal antiviral trials. Ensitrelvir, an oral SARS-CoV-2 3C-like protease inhibitor approved in Japan, remains uneva...