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Abstract Background Meningoencephalitis of unknown origin (MUO) comprises a group of noninfectious inflammatory diseases affecting the central nervous system of dogs. Previous studies have reported individual risk factor...

Multiple myeloma is a plasma cell neoplasm that accounts for approximately 1% of all tumors in dogs and is more commonly diagnosed in elderly animals. Clinical signs are generally nonspecific and may include bone pain, l...

Renal involvement is the cause of major mortality and morbidity of systemic lupus erythematosus (SLE) disease. Although regimes including pulse cyclophosphamide and corticosteroid are the most effective treatment modalit...

Huangtao Ruan,1,2,* Xiaozhao Lu,2,3,* Huan Lu,2– 4,* Haozhang Huang,2,3,* Zuxian Huang,1,2 Shangyi Tang,2,3 Ziyao Yuan,2,5 Rengui Jiang,2,3,6 Jiazhen Xin,6 Tao Tang,6 Jin Liu,1,2 Yong Li...

Abstract Background Kawasaki disease (KD) represents the leading cause of acquired heart disease in children, with timely diagnosis and treatment being crucial to prevent severe coronary complications. The widespread use...

BackgroundCoronary heart disease (CHD) frequently coexists with diabetes mellitus (DM), resulting in a complex metabolic–vascular disorder with poor cardiovascular prognosis. Oral Chinese patent medicines (OCPMs) are w...

Abstract Background Breast cancer prognosis is the result of complex interactions between tumor biology, treatment, and host factors. While germline genetic variation is increasingly incorporated into breast cancer risk ...

In recent years, considerable progress has been made in frontline therapy for elderly/physically unfit patients with CLL. The combination of obinutuzumab and chlorambucil (O-Clb) has been shown to prolong progression fre...

Triple-negative breast cancer (TNBC) is a subtype of breast cancer with strong invasiveness, limited treatment options, and poor prognosis. Its early accurate diagnosis and individualized treatment are major challenges f...

In human beings, intrarenal blood flow impedance, expressed as the resistive index (Rl) and obtained by duplex Doppler ultrasonography, has been used to aid in diagnosis and prognosis of renal failure. Higher than normal...

Abstract Background Patients with relapsed/refractory diffuse large B-cell lymphoma (R/R DLBCL) who failed bispecific antibody (BsAb) therapy face an extremely poor prognosis, necessitating exploration of effective salva...

Bullous pemphigoid is an autoimmune blistering disease that very rarely affects children. Clinical differences in locations of skin lesions led to the distinction of infantile versus childhood pemphigoid. Mucous membrane...

Numerous treatments for breast cancer have emerged in recent years, influenced by genetic and environmental factors that contribute to the disease's heterogeneity. Breast cancer stem cells are a primary driver of tumor a...

Abstract Mortality rates from breast cancer in young women have fallen considerably in high-income countries but continue to rise in low-income countries such as Morocco. Young women with breast cancer face unique challe...

Abstract Objectives Gastrointestinal neuroendocrine neoplasms (GI-NENs) exhibit heterogeneity in biological behavior, making it difficult to predict prognosis. We established the P Grade based on 68Ga-DOTANOC and 18F-FDG...

Background Studies indicate that antibodies cross-reacting with cardiac β1 adrenergic receptors are likely to play a role in the development of chronic Chagas heart disease (CCHD). In parallel, clinical trials have show...

Objectives To assess how physiotherapy contact frequency relates to clinical outcomes in patients with musculoskeletal disorders across prognostic groups, and how outcomes are associated with future healthcare costs and ...

Abstract Background Hereditary angioedema (HAE) is a rare, potentially life-threatening genetic disorder that is caused by C1-inhibitor (C1INH) deficiency or dysfunction. This scoping review sought to map recent advances...

Rongzhi Huang,1,* Zexu Zhan,1,* Shulin Huang,1 Wenlong Cao,1 Jiehua Li,1 Min Mao2 1Department of Gastrointestinal and Gland Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, T...

Background: Crohn’s disease (CD) and ulcerative colitis (UC) are the two major relapsing conditions of inflammatory bowel diseases. Case Report: A case of Crohn’s disease with orofacial manifestations in a 10 year ol...

ABSTRACT Background Myxomatous mitral valve disease (MMVD) can cause pulmonary hypertension (PH). Mitral valve repair (MVR) has been described as a surgical treatment option for MMVD, but the benefit of MVR when PH is pr...

Abstract Objective This study aims to evaluate the clinical features, efficacy of endoscopic therapy, and long-term prognosis in patients with ectopic papilla of Vater (EPV) located in the duodenal bulb. Methods A retros...

Abstract Background Wilson disease (WD) is a rare inherited copper metabolism disorder with variable prevalence worldwide. Many regions lack reliable data, leading to underestimation of burden. WD presents with hepatic, ...

In this study, the frequency of crescentic glomerulonephritis(GN) and the clinical outcome of the patients with crescentic GN were evaluated retrospectively among 532 renal biopsies performed between January 1990 and Jan...