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Abstract Bone regeneration of oral and maxillofacial defects in situ remains a significant clinical challenge. This study investigates the synergistic effects of phosphorus (P) and zinc (Zn) co-doping in wollastonite bio...

Abstract Critical-sized bone defects possess inherently limited self-healing potential, posing a persistent challenge in clinical bone repair. In recent years, numerous hydrogel systems have been developed for bone defec...

Abstract Background Current bone tissue engineering scaffolds face challenges such as inadequate mechanical support, limited biocompatibility, and suboptimal osteogenesis for treating critical-sized bone defects. This st...

ABSTRACT Peripheral nerve regeneration continues to pose a significant clinical challenge, primarily attributable to the inherently limited regenerative capacity of axons and the intricate inflammatory microenvironment t...

Abstract Background Matrix stiffness is a key feature of the mechanical microenvironment. Periodontal tissue is a multicomponent structure composed of cementum, periodontal ligament, and alveolar bone, and is essential f...

With the increasingly stringent environmental regulations on road traffic, the emission standards for particulate matter from internal combustion engines have risen significantly. Consequently, the implementation of part...

The aim of the paper is to envision urban open spaces as a strategic system for the health of the citizens, experimenting with innovative interpretation tools and design-oriented approaches. The focus is on walking, cons...

Regenerating urban public spaces also includes redesigning and planning infrastructures to promote mobility through improved accessibility. This paper presents research conducted on public housing neighborhoods (in Itali...

Background Non-scarring alopecia, including androgenetic alopecia, alopecia areata, and telogen effluvium, is highly prevalent and often associated with significant psychosocial burden. Although treatments such as minoxi...

ABSTRACT: Objective: While diabetes is known to impair dentin regenerative capacity, the specific role of endothelial nitric oxide synthase (eNOS) is poorly defined. This study aimed to elucidate how eNOS regulates the ...

AimsElectroacupuncture (EA) promotes the regeneration and repair of peripheral nerve injury (PNI) in clinical, and its underlying neuroimmune mechanisms have still not been fully clarified. Our study investigates the rol...

Abstract Bone defects present significant challenges in clinical practice due to the limitations of traditional treatments. Compared to traditional cell therapies, exosome-based therapies have emerged as a promising alte...

Traditional hepatology conceptualizes liver cirrhosis as the linear accumulation of extracellular matrix (ECM). However, the stagnation of fibrosis reversal and the persistent risk of hepatocellular carcinoma (HCC) despi...

Abstract Duchenne muscular dystrophy, caused by mutations in the DMD gene encoding dystrophin, is a severe progressive muscle-wasting disorder characterized by impaired muscle regeneration. We reveal the alternative spli...

ABSTRACT Exosomes serve as intercellular communication vectors and are involved in a broad range of physiological functions. Although exosome‐based therapies have demonstrated diverse functional potential, the regulato...

Stem cell therapy, a highly recognized approach in the field of regenerative medicine, is known for its potential to stimulate the self-healing process of the body using stem cells or their derivatives, in which urine-de...

Abstract Intervertebral disc (IVD) degenerative disease is a prevalent and debilitating spinal disease. Current treatments only focus on symptomatic relief but fail to halt disease progression or restore the native biome...

Abstract Background Circadian rhythms are endogenous, transcription-translation feedback loops that align cellular activities with the 24-h light–dark cycle. Stem-cell populations across tissues exhibit circadian oscil...

The characteristic oral environment – with its dynamic clearance, moisture, microbial load, and inflammatory potential – makes oral diseases highly prevalent and therapeutically challenging. Metal-organic frameworks ...

Abstract High-frequency regeneration through shoot organogenesis and/or somatic embryogenesis is a prerequisite for genetic transformation of plants. Cytokinins have been mainly implicated in shoot organogenesis. The pre...

IntroductionPolygonum multiflorum (PM), a traditional medicinal herb, is renowned for its regenerative effects on hair growth; however, its therapeutic application has been largely confined to crude extracts. Recent adva...

Induction heating is gaining attention as an electrified heating method for temperature swing adsorption (TSA) because it can deliver fast and uniform heat directly within the adsorbent bed. However, scaling this approac...

الملخص: Image 1 Abstract: Objective: To improve clinical and radiographic results in patients with periodontitis, this systematic review assessed the efficacy of metformin (MF) as an adjuvant to surgical and nonsu...