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The syndrome of inappropriate antidiuretic hormone secretion (SIADH) is a cause of euvolemic hyponatremia. Neoplasms, infections and some drugs are the most frequent reasons of SIADH. Brucella melitensis is an infectious...

The presence of apoplastic proteins without predicted signal peptide in the gene sequence suggests the existence of protein secretion independent of the ER/Golgi classical route. In animals, one of the pathways proposed ...

IntroductionAdrenal incidentalomas are an increasing clinical concern and, while most are non-functioning adrenal adenomas (NFAA), a relevant subset is associated with mild autonomous cortisol secretion (MACS), condition...

The increasing population of the elderly has an impact on health problems, including an increase of oral problems. One of the common oral problems is dry mouth that possibly disrupts gustatory function. The aim of this s...

Insulin secretion from pancreatic islet β-cells is governed by both metabolic and electrogenic pathways. The latter involves changes in membrane potential regulated by various potassium channels, including ATP-sensitive...

Abstract Amphibians are enjoyable globally for their culinary value and are increasingly considered alternative protein sources. However, the skin of edible amphibians, especially giant salamanders, is often discarded wi...

Primary aldosteronism (PA) is the most common cause of secondary hypertension in many populations worldwide. Although hypertension with recurrent hypokalemia from renal potassium wasting and simultaneously elevated plasm...

One of the key challenges in biology is to understand how individual cells process information and respond to perturbations. However, most of the existing single-cell analysis methods can only provide a glimpse of cell p...

Tooth extraction can lead to alveolar bone resorption, requiring regenerative approaches using biomaterial scaffolds combined with stem cells. Chitosan–hydroxyapatite (CS–HA), a well-established scaffold that mimics ...

Abstract Narcolepsy type 1 (NT1) is caused by a significant loss of orexin-producing neurons. In clinical trials, multiple orexin receptor 2 (OX2R)-selective agonists (e.g., danavorexton, TAK-994, and oveporexton) improv...

Abstract The aim of this study was to evaluate efficacies of selected lactic acid bacteria (LAB) in inducing immunoglobulin A (IgA) secretion. Twenty-five different LAB isolated from traditional fermented Korean foods we...

Foram utilizadas 42 vacas holandesas gestantes e multíparas, distribuídas ao acaso em dois grupos, com o objetivo de se determinar possíveis alterações na concentração de IGF-I no colostro e nas secreções lácte...

ABSTRACT The biochemical defense mechanisms of amphibians involve cutaneous secretions of bioactive molecules with antimicrobial activity. This study evaluated the in vitro activity of methanolic extracts from cutaneous ...

The effect of cryopreservation in IFN-tau, from bovine embryos produced in vitro was evaluated. Two treated groups (G1= fresh bovine embryos, n=59 and G2= freezed embryos, n=84) were used to study the effect of cryoprese...

Dengue virus is a major global health threat and can lead to life-threatening hemorrhagic complications due to immune activation and cytokine production. Cross-reactive antibodies to an earlier dengue virus infection are...

ABSTRACT Exosomes serve as intercellular communication vectors and are involved in a broad range of physiological functions. Although exosome‐based therapies have demonstrated diverse functional potential, the regulato...

ABSTRACTThe objective of the present study is to evaluate the effects of plant extracts on growth performance, nutrient digestibility, and immune blood characteristics in growing pigs. A total of 80 [(Landrace × Yorkshi...

Females of the South American plains vizcacha, Lagostomus maximus, show peculiar reproductive features such as massive polyovulation up to 800 oocytes per estrous cycle and an ovulatory process around mid-gestation arisi...

Hyponatremia is the most common electrolyte abnormality encountered in clinical practice. The symptoms of hyponatraemia are largely dependent on the rapidity of the development of hyponatraemia. Acute symptomatic hyponat...

Abstract Chitinases from Trichoderma species exhibit strong antifungal activity and high biocontrol potential, yet their industrial utilization has been constrained by low heterologous secretion efficiency and costly pur...

ABSTRACT Protein trafficking from the cytosol to specific sites of action is a fundamental process for bacterial survival and growth. In the monoderm gram-positive bacteria, this process involves traversing the cytoplasm...

We explored the relationship between the level of bovine leukemia virus antibodies and provirus load during natural infection. For that purpose, a set of 50 blood and milk paired samples were analyzed for the presence of...

To develop a new strategy to target recombinant proteins to the vacuolar storage system in transgenic plants, the ability of the transmembrane and cytosolic domains of Arabidopsis receptor homology-transmembrane-RING H2-...

Abstract TP53 is frequently mutated in bladder cancer and is associated with aggressive disease, yet actionable strategies that also improve responses to immune checkpoint blockade remain limited. Here we show that APR-2...