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Materias / palabras clave: Epidemias; Vacunación; Antiviral agents; Influenza Vaccines; therapeutic use

Materias / palabras clave: Medicine: Therapeutics. Pharmacology; Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy

Abstract Backgrounds Clinical trials are central in pandemic preparedness and response (PPR). This scoping review aimed to illustrate the landscape of COVID-19-related randomized controlled trials (RCTs), focusing on the...

Background. Viral infections remain a major global health threat despite advances in vaccines and antiviral drugs due to the rapid emergence of resistance and new viral pathogens. Antiviral peptides (AVPs) are promising ...

Abstract Understanding the kinetics of nanoparticle vaccine drainage to the lymph nodes and their residence time in these tissues is critical in vaccine development. Evaluating these parameters using conventional techniq...

Brucellosis, a zoonotic disease, triggers severe inflammation and reproductive complications in both humans and animals. The standard treatment protocol relies on prolonged antibiotic courses, often combining streptomyci...

Abstract Epithelial-to-mesenchymal transition (EMT) is a complex and dynamic cellular process during which epithelial cells lose their polarity and cell adhesion capabilities and subsequently express mesenchymal stem cel...

BackgroundMacrophage polarization plays a critical role in shaping the immunosuppressive tumor microenvironment (TME) of prostate cancer (PCa). Tumor-associated macrophages (TAMs), particularly those exhibiting immunoreg...

Mucosal antibody response in lower respiratory tract to COVID-19 vaccines is less studied. This cross-sectional study evaluated the respiratory mucosal antibody response in subjects vaccinated with Aikewei or CoronaVac i...

Abstract Therapeutic human papillomavirus (HPV) DNA vaccine is an attractive option to control existed HPV infection and related lesions. The two early viral oncoproteins, E6 and E7, are continuously expressed in most HP...

Background The field of extracellular vesicles (EVs) has advanced considerably in recent years with new findings stemming from technical improvements in their isolation and characterization, expanding their potential as ...

Computational modeling of protein-protein interactions (PPIs) is a high priority because it is essential for understanding nearly all cellular functions and for addressing the limitations of time-consuming experimental m...

Lassa fever is a zoonotic disease endemic to several West African countries, with seasonal outbreaks and potential to cause future epidemics. Vaccines and other medical countermeasures are in development, requiring relia...

Tissue resident memory CD4+ T cells (TRMs) populate mucosal sites and play a critical role in local immune responses. Gut TRM cells persist for extended periods in the gut mucosa where they rapidly respond to invading pa...

In recent years, there has been significant interest in an innovative transdermal delivery technology. This technology has the ability to distribute therapeutics and cosmeceuticals for various applications, such as vacci...

The animal disease is caused by the monkey virus, an orthopox virus associated with smallpox. Although endemic to central and western Africa, recent outbreaks in germ-free areas have raised global health concerns. The di...

Abstract Current treatment for atherosclerotic cardiovascular diseases (ASCVD) mainly focuses on the modification of systemic risk factors, such as hyperglycemia and hyperlipidemia. Despite significant efforts and expans...

Kaissar Tabynov,1,2,* Kairat Tabynov,2,3 Nikolai Petrovsky4,* 1International Center for Vaccinology, Kazakh National Agrarian Research University, Almaty, Kazakhstan; 2Preclinical Research Laboratory with...

Animal-bite and scratch visits to the emergency department (ED) often require time-sensitive decisions on rabies post-exposure prophylaxis (PEP) alongside tetanus prevention. In China, recent national standards and local...

We report a case of a 51-y-old female presenting with synchronous double primary malignancies: advanced endometrial cancer and early-stage lung cancer. One year a post-chemotherapy withdrawal due to toxicity, she develop...

Few systematic reviews or meta-analyses have addressed on the incidence of Bacille Calmette-Guérin (BCG) lymphadenitis in healthy children. A systematic literature search was independently conducted by two researchers u...

Human papillomavirus (HPV) is the most common sexually transmitted infection in the U.S. and the primary cause of multiple anogenital and oropharyngeal cancers. Although HPV vaccination is effective, uptake remains subop...

Background: Human papillomavirus (HPV) infection remains the most prevalent sexually transmitted viral infection worldwide and a major etiologic factor for cervical and other anogenital cancers. HPV-related precancerous ...

Human papillomavirus (HPV) vaccination is a critical yet underutilized strategy for preventing HPV-related cancers in young adults. University students represent a key demographic for catch-up vaccination owing to their ...