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Materias / palabras clave: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens

Materias / palabras clave: translational cancer therapeutics, precision oncology and biomarker development, molecularly guided clinical trials, mechanisms of therapeutic response and resistance, experimental and early-phase oncology, bench-to-beds...

Materias / palabras clave: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens

Materias / palabras clave: Medicine: Medicine (General): Medical physics. Medical radiology. Nuclear medicine; Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens

Abstract Background Disruption of cellular proteostasis leads to the accumulation and persistence of pathogenic proteins that drive oncogenesis. Key oncogenic and tumor suppressor proteins are frequently dysregulated in ...

ABSTRACT The growing interest in transferring therapeutic advances from human to veterinary medicine has spurred research into monoclonal antibodies and advanced therapies for treating cancer in small animals. This syste...

The incidence and mortality rates of breast cancer are increasing, although improvements in traditional treatments, and it remains the most frequent cancer among women globally. The increasing demand for natural suppleme...

Abstract Immune checkpoint inhibitors (ICIs) have fundamentally altered the therapeutic paradigm for head and neck squamous cell carcinoma (HNSCC); however, durable clinical benefit remains limited to biologically define...

Development of effective and safe treatments for companion animals with cancer requires the collaboration of numerous animal health professionals and the full engagement of animal owners. Establishing ‘Best Practice Re...

Chemotherapy-induced gastrointestinal dysfunction (CIGD) is a multifactorial clinical syndrome that substantially limits treatment tolerance, continuity, and quality of life in patients with cancer. Although targeted the...

Triple-negative breast cancer (TNBC) is a subtype of breast cancer with strong invasiveness, limited treatment options, and poor prognosis. Its early accurate diagnosis and individualized treatment are major challenges f...

ABSTRACT Introduction Antimicrobial resistance (AMR) is a global health crisis that poses a devastating and specific threat to immunocompromised cancer patients, who are heavily reliant on antibiotics to navigate high‐...

Abstract Integration of Artificial Intelligence (AI), particularly deep learning, into medical imaging represents a profound shift in diagnostic medicine, moving from purely descriptive analysis to advanced predictive an...

Abstract Insulin resistance (IR) has emerged as a metabolically relevant contributor to the development and progression of breast cancer (BC), with a case fatality of nearly 15%. IR mainly shows a relationship with obesi...

Abstract Background Gastric cancer (GC) remains a major global health challenge with persistently poor survival rates, largely attributable to late-stage diagnosis and the inherent limitations of conventional imaging mod...

With the widespread application of chemotherapy, immunotherapy, and targeted therapy, cardiotoxicity associated with anti-tumor treatment has gained increasing attention. Drug-induced cardiac injury can significantly imp...

Background and purpose: Deviations in radiotherapy quality can significantly affect clinical trial outcomes, including overall survival. Radiotherapy quality assurance (RTQA) is a systematic process by which a RT plan is...

The aim of this study was to explore the acute effects of high-intensity interval training (HIIT) on the microvascular circulation and vascular tumor microenvironment (TME) in a patient with uveal melanoma (UM). Addition...

PurposeThis study aims to systematically evaluate the mechanical performance of the novel treatment couch for the uLinac VisionaryTx CT-Linac (United Imaging Healthcare, China).Materials and methodsQuality assurance prot...

BackgroundSmall Nuclear Ribonucleoprotein Polypeptide A (SNRPA), an RNA-binding protein associated with HCC survival, emerges as a key regulator requiring mechanistic study.MethodsTo delineate SNRPA’s functions, we gen...

BackgroundMacrophage polarization plays a critical role in shaping the immunosuppressive tumor microenvironment (TME) of prostate cancer (PCa). Tumor-associated macrophages (TAMs), particularly those exhibiting immunoreg...

Abstract N6-methyladenosine (m6A) is the most abundant internal modification in eukaryotic mRNA and plays a crucial role in post-transcriptional gene regulation. Recent studies have revealed that m6A modification is dysr...

Background: Mantle cell lymphoma (MCL) exhibits distinct biological characteristics and marked molecular heterogeneity, with TP53 mutations associated with particularly poor clinical outcomes. Eprenetapopt (APR-246), a f...

Multiple myeloma (MM) is best understood as a dynamically evolving genomic ecosystem shaped by inherited susceptibility, early oncogenic events, and continuous selective pressures. We propose an evolutionary genomics fra...