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RAC3 down-regulation sensitizes human chronic myeloid leukemia cells to TRAIL-induced apoptosis

Colo, Georgina Pamela et al · Elsevier Science · 2007

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Author / responsible party
Colo, Georgina Pamela et al
Publisher
Elsevier Science
Year
2007
ISSN
5075-5081
ISSN
5075-5081
Language
English

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The nuclear receptor coactivator RAC3 plays important roles in many biological processes and tumorigenesis. We found that RAC3 is over-expressed in human chronic myeloid leukemia cells K562, which are normally resistant to TRAIL-induced apoptosis. RAC3 down-regulation by siRNA rendered these cells sensitive to TRAIL-induced cell death. In addition to the up-regulation of TRAIL receptors, the process involves Bid, caspases and PARP activation, loss of mitochondrial membrane potential, and release of AIF, cytochrome c and Smac/DIABLO to the cytoplasm. We conclude that RAC3 is required for TRAIL resistance and that this anti-apoptotic function is independent of its role in hormone receptor signaling. Fil: Colo, Georgina Pamela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina Fil: Rosato, Roberto R.. Virginia Commonwealth University; Estados Unidos

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APA 7

Colo, G. P. E. A. (2007). RAC3 down-regulation sensitizes human chronic myeloid leukemia cells to TRAIL-induced apoptosis. http://hdl.handle.net/11336/105931

MLA

Colo, Georgina Pamela et al. "RAC3 down-regulation sensitizes human chronic myeloid leukemia cells to TRAIL-induced apoptosis." 2007. http://hdl.handle.net/11336/105931.

Chicago

Colo, Georgina Pamela et al. 2007. "RAC3 down-regulation sensitizes human chronic myeloid leukemia cells to TRAIL-induced apoptosis.". http://hdl.handle.net/11336/105931.

Harvard

Colo, G. P. E. A. 2007, RAC3 down-regulation sensitizes human chronic myeloid leukemia cells to TRAIL-induced apoptosis, Elsevier Science, available at: http://hdl.handle.net/11336/105931 [Accessed 5 Aug. 2026].

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Title
RAC3 down-regulation sensitizes human chronic myeloid leukemia cells to TRAIL-induced apoptosis
Author / contributors
Colo, Georgina Pamela et al
Publisher
Elsevier Science
Publication year
2007
ISSN
5075-5081
ISSN
5075-5081
Language
English

Subjects

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Nuclear receptors coactivator; RAC3; Apoptosis; Leukemia; TRAIL; NF-kappaB; https://purl.org/becyt/ford/3.5; https://purl.org/becyt/ford/3; https://purl.org/becyt/ford/1.6; https://purl.org/becyt/ford/1; https://purl.org/becyt/ford/3.4; https://purl.org/becyt/ford/3
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