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Biocompatibility of core@shell particles: Cytotoxicity and genotoxicity in human osteosarcoma cells of colloidal silica spheres coated with crystalline or amorphous zirconia

Di Virgilio, Ana Laura et al · Elsevier Science · 2014

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Author / responsible party
Di Virgilio, Ana Laura et al
Publisher
Elsevier Science
Year
2014
ISSN
1383-5718
ISSN
1383-5718
Language
English

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The cytotoxicity and genotoxicity of novel colloidal silica spheres coated with crystalline or amorphous zirconia (SiO2@ZrO2 cryst or SiO2@ZrO2 am) have been studied in a human osteosarcoma cell line (MG-63), after 24 h exposure. SiO2@ZrO2 cryst and SiO2@ZrO2 am had mean diameters of 782 ± 19 and 891 ± 34 nm, respectively. SiO2@ZrO2 cryst exposure reduced cell viability, with an increase in reactive oxygen species (ROS) and a decrease of the GSH/GSSG ratio. The comet and micronucleus (MN) assays detected DNA damage at 5 and 25 g/mL, respectively. SiO2@ZrO2 am induced genotoxic action only at 10 and 50 g/mL (comet and MN assays), along with a decrease of the GSH/GSSG ratio at 50 g/mL. Both particles were found inside the cells, forming vesicles; however, none of them entered the nucleus. Our findings show that crystallization of the shell of the amorphous ZrO2 increases both cytotoxicity and genotoxicity. Fil: Di Virgilio, Ana Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; Argentina. Universidad Nacional de la Plata. Facultad de Cs.exactas. Departamento de Cs.biológicas. Cátedra Bioquímica Patologica; Argentina Fil: Arnal, Pablo Maximiliano. Provincia de Buenos Aires. Gobernación. Comision de Invest.científicas. Centro de Tecnología de Recursos Minerales y Ceramica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - la Plata. Centro de Tecnología de Recursos Minerales y Ceramica; Argentina

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APA 7

Di Virgilio, A. L. E. A. (2014). Biocompatibility of core@shell particles: Cytotoxicity and genotoxicity in human osteosarcoma cells of colloidal silica spheres coated with crystalline or amorphous zirconia. http://hdl.handle.net/11336/24809

MLA

Di Virgilio, Ana Laura et al. "Biocompatibility of core@shell particles: Cytotoxicity and genotoxicity in human osteosarcoma cells of colloidal silica spheres coated with crystalline or amorphous zirconia." 2014. http://hdl.handle.net/11336/24809.

Chicago

Di Virgilio, Ana Laura et al. 2014. "Biocompatibility of core@shell particles: Cytotoxicity and genotoxicity in human osteosarcoma cells of colloidal silica spheres coated with crystalline or amorphous zirconia.". http://hdl.handle.net/11336/24809.

Harvard

Di Virgilio, A. L. E. A. 2014, Biocompatibility of core@shell particles: Cytotoxicity and genotoxicity in human osteosarcoma cells of colloidal silica spheres coated with crystalline or amorphous zirconia, Elsevier Science, available at: http://hdl.handle.net/11336/24809 [Accessed 8 Aug. 2026].

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Title
Biocompatibility of core@shell particles: Cytotoxicity and genotoxicity in human osteosarcoma cells of colloidal silica spheres coated with crystalline or amorphous zirconia
Author / contributors
Di Virgilio, Ana Laura et al
Publisher
Elsevier Science
Publication year
2014
ISSN
1383-5718
ISSN
1383-5718
Language
English

Subjects

Explore related resources through these subjects.

Core@Shell Materials; Cytotoxicity; Genotoxicity; Zirconia; A Silica; Human Osteosarcoma Cells; https://purl.org/becyt/ford/1.6; https://purl.org/becyt/ford/1
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