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Antioxidant activity and ultrastructural alterations in Leishmania amazonensis promastigotes induced by limonoid-rich fractions from andiroba oil

Fernando ALMEIDA-SOUZA et al · Instituto Nacional de Pesquisas da Amazônia · 2024

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Author / responsible party
Fernando ALMEIDA-SOUZA et al
Publisher
Instituto Nacional de Pesquisas da Amazônia
Year
2024
ISSN
0044-5967
ISSN
0044-5967
Language
English
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"Pinta" em população nativa do Estado do Amazonas

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ABSTRACT In the Amazon region, andiroba (Carapa guianensis) oil is among the most used products by the local population due to its medicinal properties. Previously, our group described the leishmanicidal activity of three limonoid-rich fractions from andiroba oil. This work aimed to evaluate the antioxidant activity and ultrastructural changes in Leishmania amazonensis treated with these limonoid-rich fractions from andiroba oil: 6α,11β-diacetoxygedunin; 11β-hydroxygedunin; and a fraction with both 6α,11β-diacetoxygedunin +11β-hydroxygedunin. The antioxidant activity was evaluated by the DPPH method and ultrastructural changes were evaluated by transmission electron microscopy. The fraction with both 6α,11β-diacetoxygedunin + 11β-hydroxygedunin displayed the best antioxidant activity (IC50 330.35 ± 8.60 µg mL-1; p=0.0022) compared to the 6α,11β-diacetoxygedunin fraction. The three fractions induced structural changes to mitochondria and kinetoplasts of L. amazonensis, in addition to lipid bodies, vacuolization, and vesicles in the flagellar pocket, indicating that the limonoid-rich fractions from andiroba oil can induce structural damage to Leishmania.

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APA 7

al, F. A. S. E. (2024). Antioxidant activity and ultrastructural alterations in Leishmania amazonensis promastigotes induced by limonoid-rich fractions from andiroba oil. https://doi.org/10.1590/1809-4392202301131

MLA

al, Fernando ALMEIDA-SOUZA et. "Antioxidant activity and ultrastructural alterations in Leishmania amazonensis promastigotes induced by limonoid-rich fractions from andiroba oil." 2024. https://doi.org/10.1590/1809-4392202301131.

Chicago

al, Fernando ALMEIDA-SOUZA et. 2024. "Antioxidant activity and ultrastructural alterations in Leishmania amazonensis promastigotes induced by limonoid-rich fractions from andiroba oil.". https://doi.org/10.1590/1809-4392202301131.

Harvard

al, F. A. S. E. 2024, Antioxidant activity and ultrastructural alterations in Leishmania amazonensis promastigotes induced by limonoid-rich fractions from andiroba oil, Instituto Nacional de Pesquisas da Amazônia, available at: https://doi.org/10.1590/1809-4392202301131 [Accessed 7 Aug. 2026].

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Title
Antioxidant activity and ultrastructural alterations in Leishmania amazonensis promastigotes induced by limonoid-rich fractions from andiroba oil
Author / contributors
Fernando ALMEIDA-SOUZA et al
Publisher
Instituto Nacional de Pesquisas da Amazônia
Publication year
2024
ISSN
0044-5967
ISSN
0044-5967
Language
English

Subjects

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leishmaniasis; crabwood; DPPH; transmission electron microscopy; Carapa guianensis
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