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Enalapril:β-CD complex: Stability enhancement in solid state

Zoppi, Ariana et al · Elsevier · 2011

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Author / responsible party
Zoppi, Ariana et al
Publisher
Elsevier
Year
2011
ISSN
0144-8617
ISSN
0144-8617
Language
English

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Complexation of enalapril maleate with -cyclodextrin was used to overcome the known enalapril maleate–excipient interaction in solid state. The complex formation was characterized by 13C solid state nuclear magnetic resonance, X-ray powder diffraction and scanning electron microscopy. Additionally, thermogravimetric analysis (TGA) was used to evaluate the compatibility between magnesium stearate with enalapril maleate alone or in the complex form. Degradation of the drug at 40 ◦C/75% relative humidity in the presence of magnesium stearate was monitored by high performance liquid chromatography (HPLC). Enalapril maleate in the complex form was more stable than the drug alone, with the drug recovery after 6 month being: 95±1% and 82.1±0.5%, respectively. This satisfactory high stability of the enalapril:-CD complex will be potentially useful for its application as solid pharmaceutical dosage products. Fil: Zoppi, Ariana. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina Fil: Garnero, Claudia. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina

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APA 7

Zoppi, A. E. A. (2011). Enalapril:β-CD complex: Stability enhancement in solid state. http://hdl.handle.net/11336/190863

MLA

Zoppi, Ariana et al. "Enalapril:β-CD complex: Stability enhancement in solid state." 2011. http://hdl.handle.net/11336/190863.

Chicago

Zoppi, Ariana et al. 2011. "Enalapril:β-CD complex: Stability enhancement in solid state.". http://hdl.handle.net/11336/190863.

Harvard

Zoppi, A. E. A. 2011, Enalapril:β-CD complex: Stability enhancement in solid state, Elsevier, available at: http://hdl.handle.net/11336/190863 [Accessed 7 Aug. 2026].

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Title
Enalapril:β-CD complex: Stability enhancement in solid state
Author / contributors
Zoppi, Ariana et al
Publisher
Elsevier
Publication year
2011
ISSN
0144-8617
ISSN
0144-8617
Language
English

Subjects

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CHEMICAL STABILITY; COMPLEXATION; CYCLODEXTRINS; SOLID STATE NMR; THERMOGRAVIMETRIC ANALYSIS; X-RAY POWDER DIFFRACTOMETRY; https://purl.org/becyt/ford/2.10; https://purl.org/becyt/ford/2
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