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The differentiation potential of adipose tissue-derived mesenchymal stem cells into cell lineage related to male germ cells

P. Bräunig et al · Universidade Federal de Minas Gerais, Escola de Veterinária

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Author / responsible party
P. Bräunig et al
Publisher
Universidade Federal de Minas Gerais, Escola de Veterinária
ISSN
1678-4162
ISSN
1678-4162
Language
English
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ABSTRACT The adipose tissue is a reliable source of Mesenchymal stem cells (MSCs) showing a higher plasticity and transdifferentiation potential into multilineage cells. In the present study, adipose tissue-derived mesenchymal stem cells (AT-MSCs) were isolated from mice omentum and epididymis fat depots. The AT-MSCs were initially compared based on stem cell surface markers and on the mesodermal trilineage differentiation potential. Additionally, AT-MSCs, from both sources, were cultured with differentiation media containing retinoic acid (RA) and/or testicular cell-conditioned medium (TCC). The AT-MSCs expressed mesenchymal surface markers and differentiated into adipogenic, chondrogenic and osteogenic lineages. Only omentum-derived AT-MSCs expressed one important gene marker related to male germ cell lineages, after the differentiation treatment with RA. These findings reaffirm the importance of adipose tissue as a source of multipotent stromal-stem cells, as well as, MSCs source regarding differentiation purpose.

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APA 7

al, P. B. E. (s. f.). The differentiation potential of adipose tissue-derived mesenchymal stem cells into cell lineage related to male germ cells. https://doi.org/10.1590/1678-4162-9132

MLA

al, P. Bräunig et. "The differentiation potential of adipose tissue-derived mesenchymal stem cells into cell lineage related to male germ cells.". https://doi.org/10.1590/1678-4162-9132.

Chicago

al, P. Bräunig et. s. f. "The differentiation potential of adipose tissue-derived mesenchymal stem cells into cell lineage related to male germ cells.". https://doi.org/10.1590/1678-4162-9132.

Harvard

al, P. B. E. s. f, The differentiation potential of adipose tissue-derived mesenchymal stem cells into cell lineage related to male germ cells, Universidade Federal de Minas Gerais, Escola de Veterinária, available at: https://doi.org/10.1590/1678-4162-9132 [Accessed 8 Aug. 2026].

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Title
The differentiation potential of adipose tissue-derived mesenchymal stem cells into cell lineage related to male germ cells
Author / contributors
P. Bräunig et al
Publisher
Universidade Federal de Minas Gerais, Escola de Veterinária
ISSN
1678-4162
ISSN
1678-4162
Language
English

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Gdnf; ácido retinóico; células-tronco somáticas; meio condicionado testicular
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