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Lycopene regulates the JNK/p38MAPK signalling pathway and alleviates reproductive oxidative stress and apoptosis induced by heat stress in male rats

Longsheng Wei et al · Elsevier · 2026

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Author / responsible party
Longsheng Wei et al
Publisher
Elsevier
Year
2026
ISSN
1756-4646
ISSN
1756-4646
Language
English

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This study aimed to explore the effects of lycopene (LYC) on testicular and sperm damage induced by heat stress in male rats and its potential protective mechanism. Male rats were gavaged with lycopene, and their scrotums were immersed in a 42 °C water bath for 20 min. After the intervention, various indicators were observed. The results showed that lycopene reduced apoptotic responses and oxidative stress, promoted the expression of spermatogenesis genes, and improved sperm quality and the pathological morphology of seminiferous tubules. It also increased sperm count and Johnson score. In conclusion, lycopene can alleviate testicular and sperm damage caused by heat stress, and this protective mechanism may be achieved by regulating the JNK/p38MAPK signalling pathway.

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APA 7

al, L. W. E. (2026). Lycopene regulates the JNK/p38MAPK signalling pathway and alleviates reproductive oxidative stress and apoptosis induced by heat stress in male rats. https://doi.org/10.1016/j.jff.2026.107258

MLA

al, Longsheng Wei et. "Lycopene regulates the JNK/p38MAPK signalling pathway and alleviates reproductive oxidative stress and apoptosis induced by heat stress in male rats." 2026. https://doi.org/10.1016/j.jff.2026.107258.

Chicago

al, Longsheng Wei et. 2026. "Lycopene regulates the JNK/p38MAPK signalling pathway and alleviates reproductive oxidative stress and apoptosis induced by heat stress in male rats.". https://doi.org/10.1016/j.jff.2026.107258.

Harvard

al, L. W. E. 2026, Lycopene regulates the JNK/p38MAPK signalling pathway and alleviates reproductive oxidative stress and apoptosis induced by heat stress in male rats, Elsevier, available at: https://doi.org/10.1016/j.jff.2026.107258 [Accessed 8 Aug. 2026].

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Title
Lycopene regulates the JNK/p38MAPK signalling pathway and alleviates reproductive oxidative stress and apoptosis induced by heat stress in male rats
Author / contributors
Longsheng Wei et al
Publisher
Elsevier
Publication year
2026
ISSN
1756-4646
ISSN
1756-4646
Language
English

Subjects

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Heat stress; Lycopene; Apoptosis; JNK/p38MAPK; Spermatogenesis
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