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Synthesis of carboxyl-functionalized poly(ethylene glycol)s via enzymatic catalysis

Aswathy Sasidharan Pillai et al · Budapest University of Technology and Economics · 2026

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Author / responsible party
Aswathy Sasidharan Pillai et al
Publisher
Budapest University of Technology and Economics
Year
2026
ISSN
1788-618X
ISSN
1788-618X
Language
English

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In this study, we present an effective chemo-enzymatic method for synthesizing di- and tetra-carboxyl–functionalized poly(ethylene glycol)s (PEGs) using Candida antarctica lipase B (CALB). PEG-diacid was synthesized through CALB-catalyzed Michael addition of 3-mercaptopropionic acid (3-MPA) to PEG-diacrylate. We found that the reactions proceeded in a stepwise manner, first producing monoacid. The synthesis of diacid required additional fresh CALB and 3-MPA. The structure of the products was confirmed by 800 MHz 1H NMR. PEG-tetraacid was synthesized in a single step via CALB-catalyzed Michael addition of acrylic acid to PEG-diamine. In both cases, the CALB-Catalyzed Michael addition reactions effectively produced carboxyl-functionalized PEGs.

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APA 7

al, A. S. P. E. (2026). Synthesis of carboxyl-functionalized poly(ethylene glycol)s via enzymatic catalysis. https://doi.org/10.3144/expresspolymlett.2026.47

MLA

al, Aswathy Sasidharan Pillai et. "Synthesis of carboxyl-functionalized poly(ethylene glycol)s via enzymatic catalysis." 2026. https://doi.org/10.3144/expresspolymlett.2026.47.

Chicago

al, Aswathy Sasidharan Pillai et. 2026. "Synthesis of carboxyl-functionalized poly(ethylene glycol)s via enzymatic catalysis.". https://doi.org/10.3144/expresspolymlett.2026.47.

Harvard

al, A. S. P. E. 2026, Synthesis of carboxyl-functionalized poly(ethylene glycol)s via enzymatic catalysis, Budapest University of Technology and Economics, available at: https://doi.org/10.3144/expresspolymlett.2026.47 [Accessed 8 Aug. 2026].

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Title
Synthesis of carboxyl-functionalized poly(ethylene glycol)s via enzymatic catalysis
Author / contributors
Aswathy Sasidharan Pillai et al
Publisher
Budapest University of Technology and Economics
Publication year
2026
ISSN
1788-618X
ISSN
1788-618X
Language
English

Subjects

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biocompatilility; biopolymer; functional polymer; biomedical polymer; catalyst; biomaterial
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