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Metagenomic biomarker discovery and explanation

Nicola Segata; Jacques Izard; Levi Waldron; Dirk Gevers; Larisa Miropolsky; Wendy S. Garrett; Curtis Huttenhower · Genome biology · 2011

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Author / responsible party
Nicola Segata; Jacques Izard; Levi Waldron; Dirk Gevers; Larisa Miropolsky; Wendy S. Garrett; Curtis Huttenhower
Publisher
Genome biology
Year
2011
Language
English

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This study describes and validates a new method for metagenomic biomarker discovery by way of class comparison, tests of biological consistency and effect size estimation. This addresses the challenge of finding organisms, genes, or pathways that consistently explain the differences between two or more microbial communities, which is a central problem to the study of metagenomics. We extensively validate our method on several microbiomes and a convenient online interface for the method is provided at http://huttenhower.sph.harvard.edu/lefse/.

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APA 7

Segata, N, Izard, J, Waldron, L, Gevers, D, Miropolsky, L, Garrett, W. S, & Huttenhower, C. (2011). Metagenomic biomarker discovery and explanation. https://doi.org/10.1186/gb-2011-12-6-r60

MLA

Segata, Nicola, et al. "Metagenomic biomarker discovery and explanation." 2011. https://doi.org/10.1186/gb-2011-12-6-r60.

Chicago

Segata, Nicola, Jacques Izard, Levi Waldron, Dirk Gevers, Larisa Miropolsky, Wendy S. Garrett, and Curtis Huttenhower. 2011. "Metagenomic biomarker discovery and explanation.". https://doi.org/10.1186/gb-2011-12-6-r60.

Harvard

Segata, N. et al. 2011, Metagenomic biomarker discovery and explanation, Genome biology, available at: https://doi.org/10.1186/gb-2011-12-6-r60 [Accessed 8 Aug. 2026].

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Resource details

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Title
Metagenomic biomarker discovery and explanation
Author / contributors
Nicola Segata; Jacques Izard; Levi Waldron; Dirk Gevers; Larisa Miropolsky; Wendy S. Garrett; Curtis Huttenhower
Publisher
Genome biology
Publication year
2011
Language
English

Subjects

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Metagenomics; Biology; Computational biology; Human genetics; Genome Biology; Biomarker discovery; Evolutionary biology; Biomarker; Genomics; Genetics; Bioinformatics; Proteomics
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