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SWISS-MODEL: homology modelling of protein structures and complexes

Andrew Waterhouse; Martino Bertoni; Stefan Bienert; Gabriel Studer; Gerardo Tauriello; Rafal Gumienny; Florian Heer; Tjaart de Beer · Nucleic Acids Research · 2018

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Author / responsible party
Andrew Waterhouse; Martino Bertoni; Stefan Bienert; Gabriel Studer; Gerardo Tauriello; Rafal Gumienny; Florian Heer; Tjaart de Beer
Publisher
Nucleic Acids Research
Year
2018
Language
English

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Homology modelling has matured into an important technique in structural biology, significantly contributing to narrowing the gap between known protein sequences and experimentally determined structures. Fully automated workflows and servers simplify and streamline the homology modelling process, also allowing users without a specific computational expertise to generate reliable protein models and have easy access to modelling results, their visualization and interpretation. Here, we present an update to the SWISS-MODEL server, which pioneered the field of automated modelling 25 years ago and been continuously further developed. Recently, its functionality has been extended to the modelling of homo- and heteromeric complexes. Starting from the amino acid sequences of the interacting proteins, both the stoichiometry and the overall structure of the complex are inferred by homology modelling. Other major improvements include the implementation of a new modelling engine, ProMod3 and the introduction a new local model quality estimation method, QMEANDisCo. SWISS-MODEL is freely available at https://swissmodel.expasy.org.

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APA 7

Waterhouse, A, Bertoni, M, Bienert, S, Studer, G, Tauriello, G, Gumienny, R, Heer, F, & Beer, T. D. (2018). SWISS-MODEL: homology modelling of protein structures and complexes. https://doi.org/10.1093/nar/gky427

MLA

Waterhouse, Andrew, et al. "SWISS-MODEL: homology modelling of protein structures and complexes." 2018. https://doi.org/10.1093/nar/gky427.

Chicago

Waterhouse, Andrew, Martino Bertoni, Stefan Bienert, Gabriel Studer, Gerardo Tauriello, Rafal Gumienny, Florian Heer, and Tjaart de Beer. 2018. "SWISS-MODEL: homology modelling of protein structures and complexes.". https://doi.org/10.1093/nar/gky427.

Harvard

Waterhouse, A. et al. 2018, SWISS-MODEL: homology modelling of protein structures and complexes, Nucleic Acids Research, available at: https://doi.org/10.1093/nar/gky427 [Accessed 5 Aug. 2026].

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Title
SWISS-MODEL: homology modelling of protein structures and complexes
Author / contributors
Andrew Waterhouse; Martino Bertoni; Stefan Bienert; Gabriel Studer; Gerardo Tauriello; Rafal Gumienny; Florian Heer; Tjaart de Beer
Publisher
Nucleic Acids Research
Publication year
2018
Language
English

Subjects

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Homology modeling; Workflow; Biology; Homology (biology); Computational biology; Visualization; Computer science; Bioinformatics; Data mining; Amino acid; Genetics; Database
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