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ATG16L1 and OPTN as a novel prognostic gene expression signature in acute myeloid leukemia survival

Alexandra Teixeira et al · Frontiers Media S.A · 2026

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Author / responsible party
Alexandra Teixeira et al
Publisher
Frontiers Media S.A
Year
2026
ISSN
2234-943X
ISSN
2234-943X
Language
English

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Acute myeloid leukemia (AML) is the most frequent type of leukaemia in adults, often with poor outcomes due to the complex genetic landscape and low treatment efficacy. Autophagy, a conserved degradation process, plays an indispensable and context-dependent role in AML. This work explored the prognostic impact of autophagy-related genes compared to known AML-related genes. A two-gene signature (ATG16L1-OPTN) demonstrated that the expression of these autophagy-related genes correlates significantly with overall survival (OS). Cox regression analysis and validation in two larger cohorts (BEATAML2andTCGA LAML) confirmed the association of this signature with worst OS, reinforcing its clinical relevance. These results suggest the ATG16L1-OPTN signature as a novel and robust prognostic marker for predicting OS in AML patients.

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APA 7

al, A. T. E. (2026). ATG16L1 and OPTN as a novel prognostic gene expression signature in acute myeloid leukemia survival. https://doi.org/10.3389/fonc.2026.1784384

MLA

al, Alexandra Teixeira et. "ATG16L1 and OPTN as a novel prognostic gene expression signature in acute myeloid leukemia survival." 2026. https://doi.org/10.3389/fonc.2026.1784384.

Chicago

al, Alexandra Teixeira et. 2026. "ATG16L1 and OPTN as a novel prognostic gene expression signature in acute myeloid leukemia survival.". https://doi.org/10.3389/fonc.2026.1784384.

Harvard

al, A. T. E. 2026, ATG16L1 and OPTN as a novel prognostic gene expression signature in acute myeloid leukemia survival, Frontiers Media S.A, available at: https://doi.org/10.3389/fonc.2026.1784384 [Accessed 7 Aug. 2026].

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Title
ATG16L1 and OPTN as a novel prognostic gene expression signature in acute myeloid leukemia survival
Author / contributors
Alexandra Teixeira et al
Publisher
Frontiers Media S.A
Publication year
2026
ISSN
2234-943X
ISSN
2234-943X
Language
English

Subjects

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acute myeloid leukemia (AML); ATG16L1; autophagy; OPTN; overall survival (OS)
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